Association between ultra-processed food consumption and gut microbiota in senior subjects with overweight/obesity and metabolic syndrome
The production and consumption of ultra-processed foods (UPF) has increased considerably during the last years worldwide. Collective evidence shows the association between UPF consumption and adverse health outcomes, including inflammatory gastro-intestinal disorders and obesity. The gut microbiota...
| Autores: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:282907 |
| Acceso en línea: | https://ddd.uab.cat/record/282907 https://dx.doi.org/urn:doi:10.3389/fnut.2022.976547 |
| Access Level: | acceso abierto |
| Palabra clave: | 16s sequencing Gut microbiota Mediterranean diet Metabolic syndrome Obesity Overweight Ultra-processed food |
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Association between ultra-processed food consumption and gut microbiota in senior subjects with overweight/obesity and metabolic syndrome |
| title |
Association between ultra-processed food consumption and gut microbiota in senior subjects with overweight/obesity and metabolic syndrome |
| spellingShingle |
Association between ultra-processed food consumption and gut microbiota in senior subjects with overweight/obesity and metabolic syndrome Atzeni, Alessandro 16s sequencing Gut microbiota Mediterranean diet Metabolic syndrome Obesity Overweight Ultra-processed food |
| title_short |
Association between ultra-processed food consumption and gut microbiota in senior subjects with overweight/obesity and metabolic syndrome |
| title_full |
Association between ultra-processed food consumption and gut microbiota in senior subjects with overweight/obesity and metabolic syndrome |
| title_fullStr |
Association between ultra-processed food consumption and gut microbiota in senior subjects with overweight/obesity and metabolic syndrome |
| title_full_unstemmed |
Association between ultra-processed food consumption and gut microbiota in senior subjects with overweight/obesity and metabolic syndrome |
| title_sort |
Association between ultra-processed food consumption and gut microbiota in senior subjects with overweight/obesity and metabolic syndrome |
| dc.creator.none.fl_str_mv |
Atzeni, Alessandro Martínez, María Ágeles Babio, Nancy|||0000-0003-3527-5277 Konstanti, Prokopis Tinahones, Francisco J.|||0000-0001-6871-4403 Vioque, Jesús|||0000-0002-2284-148X Corella, Dolores|||0000-0002-2366-4104 Fitó, Montserrat|||0000-0002-1817-483X Vidal, Josep|||0000-0002-4564-4518 Moreno-Indias, Isabel Pertusa-Martinez, Salvador Álvarez-Sala, Andrea Castañer, Olga|||0000-0003-3169-997X Goday Arnó, Albert|||0000-0001-7356-1595 Damas-Fuentes, Miguel Belzer, Clara Martínez-Gonzalez, Miguel Á. Hu, Frank B.. Salas-Salvadó, Jordi|||0000-0003-2700-7459 |
| author |
Atzeni, Alessandro |
| author_facet |
Atzeni, Alessandro Martínez, María Ágeles Babio, Nancy|||0000-0003-3527-5277 Konstanti, Prokopis Tinahones, Francisco J.|||0000-0001-6871-4403 Vioque, Jesús|||0000-0002-2284-148X Corella, Dolores|||0000-0002-2366-4104 Fitó, Montserrat|||0000-0002-1817-483X Vidal, Josep|||0000-0002-4564-4518 Moreno-Indias, Isabel Pertusa-Martinez, Salvador Álvarez-Sala, Andrea Castañer, Olga|||0000-0003-3169-997X Goday Arnó, Albert|||0000-0001-7356-1595 Damas-Fuentes, Miguel Belzer, Clara Martínez-Gonzalez, Miguel Á. Hu, Frank B.. Salas-Salvadó, Jordi|||0000-0003-2700-7459 |
| author_role |
author |
| author2 |
Martínez, María Ágeles Babio, Nancy|||0000-0003-3527-5277 Konstanti, Prokopis Tinahones, Francisco J.|||0000-0001-6871-4403 Vioque, Jesús|||0000-0002-2284-148X Corella, Dolores|||0000-0002-2366-4104 Fitó, Montserrat|||0000-0002-1817-483X Vidal, Josep|||0000-0002-4564-4518 Moreno-Indias, Isabel Pertusa-Martinez, Salvador Álvarez-Sala, Andrea Castañer, Olga|||0000-0003-3169-997X Goday Arnó, Albert|||0000-0001-7356-1595 Damas-Fuentes, Miguel Belzer, Clara Martínez-Gonzalez, Miguel Á. Hu, Frank B.. Salas-Salvadó, Jordi|||0000-0003-2700-7459 |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
16s sequencing Gut microbiota Mediterranean diet Metabolic syndrome Obesity Overweight Ultra-processed food |
| topic |
16s sequencing Gut microbiota Mediterranean diet Metabolic syndrome Obesity Overweight Ultra-processed food |
| description |
The production and consumption of ultra-processed foods (UPF) has increased considerably during the last years worldwide. Collective evidence shows the association between UPF consumption and adverse health outcomes, including inflammatory gastro-intestinal disorders and obesity. The gut microbiota has been suggested as potential mediator of the effects of UPF consumption on metabolism and health. However, few studies have been conducted in order to elucidate these aspects. Therefore, the aim of the present study was to assess the cross-sectional associations between UPF consumption and gut microbiota in a population of senior subjects (n = 645) within the frame of the PREDIMED-Plus trial. Eligible participants were men and women (aged 55-75 years), without documented history of cardiovascular disease at enrollment, with overweight/obesity (body mass index ≤ 27 and <40 kg/m 2) and metabolic syndrome. Using the information of food frequency questionnaires, the consumption of UPF, expressed as a percentage of total dietary energy intake in kcal/day, was calculated considering those food items classified in group 4 of NOVA system. Population was categorized according to tertiles of UPF consumption. Taxonomic fecal microbiota information, along with blood biochemical parameters, anthropometric measurements and clinical data were obtained. Bioinformatics analysis was performed to study the association between fecal microbiota composition and UPF consumption. We observed that subjects allocated in the highest tertile of UPF consumption (21.4 ± 5.0 % kcal/day) presented lower adherence to MedDiet (p < 0.001) and higher total energy intake (p < 0.001). The taxonomic analysis of the fecal microbiota revealed a significant (Benjamini-Hochberg adjusted p < 0.2) positive association between specific taxa and tertiles (T) of UPF consumption: Alloprevotella (p = 0.041 vs. T2; p = 0.065 vs. T3), Negativibacillus (p = 0.096 vs. T3), Prevotella (p = 0.116 vs. T3), and Sutterella (p = 0.116 vs. T2). UPF consumption was positively associated with lower adherence to MedDiet and higher total energy intake in senior subjects with overweight obesity and metabolic syndrome. In addition, positive association with specific fecal microbiota taxa related to inflammatory gastro-intestinal diseases and low consumption of fruits and vegetables, was observed. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/282907 https://dx.doi.org/urn:doi:10.3389/fnut.2022.976547 |
| url |
https://ddd.uab.cat/record/282907 https://dx.doi.org/urn:doi:10.3389/fnut.2022.976547 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI13/00462 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI16/00501 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00576 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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1869420551030702080 |
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Association between ultra-processed food consumption and gut microbiota in senior subjects with overweight/obesity and metabolic syndromeAtzeni, AlessandroMartínez, María ÁgelesBabio, Nancy|||0000-0003-3527-5277Konstanti, ProkopisTinahones, Francisco J.|||0000-0001-6871-4403Vioque, Jesús|||0000-0002-2284-148XCorella, Dolores|||0000-0002-2366-4104Fitó, Montserrat|||0000-0002-1817-483XVidal, Josep|||0000-0002-4564-4518Moreno-Indias, IsabelPertusa-Martinez, SalvadorÁlvarez-Sala, AndreaCastañer, Olga|||0000-0003-3169-997XGoday Arnó, Albert|||0000-0001-7356-1595Damas-Fuentes, MiguelBelzer, ClaraMartínez-Gonzalez, Miguel Á.Hu, Frank B..Salas-Salvadó, Jordi|||0000-0003-2700-745916s sequencingGut microbiotaMediterranean dietMetabolic syndromeObesityOverweightUltra-processed foodThe production and consumption of ultra-processed foods (UPF) has increased considerably during the last years worldwide. Collective evidence shows the association between UPF consumption and adverse health outcomes, including inflammatory gastro-intestinal disorders and obesity. The gut microbiota has been suggested as potential mediator of the effects of UPF consumption on metabolism and health. However, few studies have been conducted in order to elucidate these aspects. Therefore, the aim of the present study was to assess the cross-sectional associations between UPF consumption and gut microbiota in a population of senior subjects (n = 645) within the frame of the PREDIMED-Plus trial. Eligible participants were men and women (aged 55-75 years), without documented history of cardiovascular disease at enrollment, with overweight/obesity (body mass index ≤ 27 and <40 kg/m 2) and metabolic syndrome. Using the information of food frequency questionnaires, the consumption of UPF, expressed as a percentage of total dietary energy intake in kcal/day, was calculated considering those food items classified in group 4 of NOVA system. Population was categorized according to tertiles of UPF consumption. Taxonomic fecal microbiota information, along with blood biochemical parameters, anthropometric measurements and clinical data were obtained. Bioinformatics analysis was performed to study the association between fecal microbiota composition and UPF consumption. We observed that subjects allocated in the highest tertile of UPF consumption (21.4 ± 5.0 % kcal/day) presented lower adherence to MedDiet (p < 0.001) and higher total energy intake (p < 0.001). The taxonomic analysis of the fecal microbiota revealed a significant (Benjamini-Hochberg adjusted p < 0.2) positive association between specific taxa and tertiles (T) of UPF consumption: Alloprevotella (p = 0.041 vs. T2; p = 0.065 vs. T3), Negativibacillus (p = 0.096 vs. T3), Prevotella (p = 0.116 vs. T3), and Sutterella (p = 0.116 vs. T2). UPF consumption was positively associated with lower adherence to MedDiet and higher total energy intake in senior subjects with overweight obesity and metabolic syndrome. In addition, positive association with specific fecal microbiota taxa related to inflammatory gastro-intestinal diseases and low consumption of fruits and vegetables, was observed.Universitat Autònoma de Barcelona 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/282907https://dx.doi.org/urn:doi:10.3389/fnut.2022.976547reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI13/00462Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI16/00501Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00576open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2829072026-06-06T12:50:31Z |
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15,300719 |