Beneficial effects of Limosilactobacillus fermentum CECT 5716 administration to infants delivered by Cesarean Section

Cesarean section (CS) disrupts the natural microbiota colonization process in infants, which might compromise immune system maturation, leading to a higher risk of infections. We evaluated the effect of the probiotic Limosilactobacillus (L.) fermentum CECT 5716 on the incidence of gastrointestinal a...

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Authors: Blanco-Rojo, R., Maldonado, J, Schaubeck, M., Özen, M., López-Huertas, Eduardo, Olivares, M.
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:dnet:digitalcsic_::8bc6d40052f9b634612895baa5115f01
Online Access:http://hdl.handle.net/10261/286547
Access Level:Open access
Keyword:Cesarean section, Probiotics, Infant formula, Gastrointestinal infections, Respiratory infections
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spelling Beneficial effects of Limosilactobacillus fermentum CECT 5716 administration to infants delivered by Cesarean SectionBlanco-Rojo, R.Maldonado, JSchaubeck, M.Özen, M.López-Huertas, EduardoOlivares, M.Cesarean section, Probiotics, Infant formula, Gastrointestinal infections, Respiratory infectionsCesarean section (CS) disrupts the natural microbiota colonization process in infants, which might compromise immune system maturation, leading to a higher risk of infections. We evaluated the effect of the probiotic Limosilactobacillus (L.) fermentum CECT 5716 on the incidence of gastrointestinal and respiratory infections in the CS infant subgroups (n = 173) of three randomized clinical trials in which this probiotic strain was demonstrated to be safe and effective for preventing infections. Therefore, the data for the CS infants were extracted to obtain the incidence rate ratio (IRR) and 95% CI for gastrointestinal and respiratory infections for each study and were then combined to obtain a pooled IRR and 95% CI using the generic inverse variance method. There was a significant reduction of 73% in the incidence of gastrointestinal infections in CS infants receiving L. fermentum CECT 5716 compared with those receiving the control formula [n = 173, IRR: 0.27 (0.13, 0.53), p = 0.0002]. Regarding respiratory infections, although pooled results showed a reduction of 14% in the probiotic group, the difference was not statistically significant [n = 173, IRR (95% CI): 0.86 (0.67, 1.11), p = 0.25]. In conclusion, the administration of L. fermentum CECT 5716 to CS-born infants protects them from gastrointestinal infections by reducing the risk by up to 73% in this population.Frontiers MediaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2023202320222023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/286547reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3389/fped.2022.906924Síinfo:eu-repo/semantics/openAccessoai:dnet:digitalcsic_::8bc6d40052f9b634612895baa5115f012026-05-22T06:33:51Z
dc.title.none.fl_str_mv Beneficial effects of Limosilactobacillus fermentum CECT 5716 administration to infants delivered by Cesarean Section
title Beneficial effects of Limosilactobacillus fermentum CECT 5716 administration to infants delivered by Cesarean Section
spellingShingle Beneficial effects of Limosilactobacillus fermentum CECT 5716 administration to infants delivered by Cesarean Section
Blanco-Rojo, R.
Cesarean section, Probiotics, Infant formula, Gastrointestinal infections, Respiratory infections
title_short Beneficial effects of Limosilactobacillus fermentum CECT 5716 administration to infants delivered by Cesarean Section
title_full Beneficial effects of Limosilactobacillus fermentum CECT 5716 administration to infants delivered by Cesarean Section
title_fullStr Beneficial effects of Limosilactobacillus fermentum CECT 5716 administration to infants delivered by Cesarean Section
title_full_unstemmed Beneficial effects of Limosilactobacillus fermentum CECT 5716 administration to infants delivered by Cesarean Section
title_sort Beneficial effects of Limosilactobacillus fermentum CECT 5716 administration to infants delivered by Cesarean Section
dc.creator.none.fl_str_mv Blanco-Rojo, R.
Maldonado, J
Schaubeck, M.
Özen, M.
López-Huertas, Eduardo
Olivares, M.
author Blanco-Rojo, R.
author_facet Blanco-Rojo, R.
Maldonado, J
Schaubeck, M.
Özen, M.
López-Huertas, Eduardo
Olivares, M.
author_role author
author2 Maldonado, J
Schaubeck, M.
Özen, M.
López-Huertas, Eduardo
Olivares, M.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cesarean section, Probiotics, Infant formula, Gastrointestinal infections, Respiratory infections
topic Cesarean section, Probiotics, Infant formula, Gastrointestinal infections, Respiratory infections
description Cesarean section (CS) disrupts the natural microbiota colonization process in infants, which might compromise immune system maturation, leading to a higher risk of infections. We evaluated the effect of the probiotic Limosilactobacillus (L.) fermentum CECT 5716 on the incidence of gastrointestinal and respiratory infections in the CS infant subgroups (n = 173) of three randomized clinical trials in which this probiotic strain was demonstrated to be safe and effective for preventing infections. Therefore, the data for the CS infants were extracted to obtain the incidence rate ratio (IRR) and 95% CI for gastrointestinal and respiratory infections for each study and were then combined to obtain a pooled IRR and 95% CI using the generic inverse variance method. There was a significant reduction of 73% in the incidence of gastrointestinal infections in CS infants receiving L. fermentum CECT 5716 compared with those receiving the control formula [n = 173, IRR: 0.27 (0.13, 0.53), p = 0.0002]. Regarding respiratory infections, although pooled results showed a reduction of 14% in the probiotic group, the difference was not statistically significant [n = 173, IRR (95% CI): 0.86 (0.67, 1.11), p = 0.25]. In conclusion, the administration of L. fermentum CECT 5716 to CS-born infants protects them from gastrointestinal infections by reducing the risk by up to 73% in this population.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/286547
url http://hdl.handle.net/10261/286547
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3389/fped.2022.906924
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
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