Prevalence of Sjogren's syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases

To estimate the prevalence of Sjogren's syndrome (SS) in the adult Spanish population we performed a population-based multicenter cross-sectional study. Cases were defined by the American-European Consensus Group criteria proposed in 2002. A total of 4,916 subjects aged 20 years or over were in...

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Autores: Narváez, Javier, Sánchez Fernández, Simón Ángel, Seoane Mato, Daniel, Díaz González, Federico, Bustabad, Sagrario
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/171791
Acceso en línea:https://hdl.handle.net/2445/171791
Access Level:acceso abierto
Palabra clave:Síndrome de Sjögren
Malalties autoimmunitàries
Sjogren's syndrome
Autoimmune diseases
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spelling Prevalence of Sjogren's syndrome in the general adult population in Spain: estimating the proportion of undiagnosed casesNarváez, JavierSánchez Fernández, Simón ÁngelSeoane Mato, DanielDíaz González, FedericoBustabad, SagrarioSíndrome de SjögrenMalalties autoimmunitàriesSjogren's syndromeAutoimmune diseasesTo estimate the prevalence of Sjogren's syndrome (SS) in the adult Spanish population we performed a population-based multicenter cross-sectional study. Cases were defined by the American-European Consensus Group criteria proposed in 2002. A total of 4,916 subjects aged 20 years or over were included. The estimated prevalence of SS (including primary and secondary forms) in the adult population in Spain was 0.33% (95% CI 0.21-0.53). Extrapolating to the total population of the country aged >= 20 years (around 37.7 million persons), there would be around 125,000 cases of SS in Spain. Considering only primary SS, the estimated prevalence was 0.25% (95% CI 0.15-0.43) or 1 person in 400. The prevalence of primary SS in Spain is comparable to that reported in other European studies with a similar design and diagnostic criteria. Based on these results, primary SS could not be considered a rare (orphan) disease. Only 50% of cases had already been diagnosed with SS prior EPISER 2016 study, confirming the existence of a non-negligible proportion of undiagnosed cases in the general population.Nature Research2020202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/171791Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41598-020-67462-zScientific Reports, 2020, vol. 10https://doi.org/10.1038/s41598-020-67462-zcc by (c) Narváez et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1717912026-05-29T05:05:01Z
dc.title.none.fl_str_mv Prevalence of Sjogren's syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases
title Prevalence of Sjogren's syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases
spellingShingle Prevalence of Sjogren's syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases
Narváez, Javier
Síndrome de Sjögren
Malalties autoimmunitàries
Sjogren's syndrome
Autoimmune diseases
title_short Prevalence of Sjogren's syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases
title_full Prevalence of Sjogren's syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases
title_fullStr Prevalence of Sjogren's syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases
title_full_unstemmed Prevalence of Sjogren's syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases
title_sort Prevalence of Sjogren's syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases
dc.creator.none.fl_str_mv Narváez, Javier
Sánchez Fernández, Simón Ángel
Seoane Mato, Daniel
Díaz González, Federico
Bustabad, Sagrario
author Narváez, Javier
author_facet Narváez, Javier
Sánchez Fernández, Simón Ángel
Seoane Mato, Daniel
Díaz González, Federico
Bustabad, Sagrario
author_role author
author2 Sánchez Fernández, Simón Ángel
Seoane Mato, Daniel
Díaz González, Federico
Bustabad, Sagrario
author2_role author
author
author
author
dc.subject.none.fl_str_mv Síndrome de Sjögren
Malalties autoimmunitàries
Sjogren's syndrome
Autoimmune diseases
topic Síndrome de Sjögren
Malalties autoimmunitàries
Sjogren's syndrome
Autoimmune diseases
description To estimate the prevalence of Sjogren's syndrome (SS) in the adult Spanish population we performed a population-based multicenter cross-sectional study. Cases were defined by the American-European Consensus Group criteria proposed in 2002. A total of 4,916 subjects aged 20 years or over were included. The estimated prevalence of SS (including primary and secondary forms) in the adult population in Spain was 0.33% (95% CI 0.21-0.53). Extrapolating to the total population of the country aged >= 20 years (around 37.7 million persons), there would be around 125,000 cases of SS in Spain. Considering only primary SS, the estimated prevalence was 0.25% (95% CI 0.15-0.43) or 1 person in 400. The prevalence of primary SS in Spain is comparable to that reported in other European studies with a similar design and diagnostic criteria. Based on these results, primary SS could not be considered a rare (orphan) disease. Only 50% of cases had already been diagnosed with SS prior EPISER 2016 study, confirming the existence of a non-negligible proportion of undiagnosed cases in the general population.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/171791
url https://hdl.handle.net/2445/171791
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-020-67462-z
Scientific Reports, 2020, vol. 10
https://doi.org/10.1038/s41598-020-67462-z
dc.rights.none.fl_str_mv cc by (c) Narváez et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Narváez et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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