Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, Xpert®MTB/RIF

Currently, pulmonary tuberculosis (TB) isolation recommendations are based on serial sputum smear microscopy. To assess infectiousness of smear-negative/GeneXpert-positive (Sm-/GXpert+) pulmonary TB, we evaluated 511 contacts of pulmonary TB patients attended at a teaching hospital in Spain (2010-20...

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Autores: Camprubí Ferrer, Daniel, Gomila Grange, Aina, Grijota Camino, Mª de los Desamparados, Soldevila-Boixader, Laura, Luque, Maria J., Alcaide Fernández de Vega, Fernando, Dorca i Sargatal, Jordi, Santín Cerezales, Miguel
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2020
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/204083
Acesso em linha:https://hdl.handle.net/2445/204083
Access Level:Acceso aberto
Palavra-chave:Tuberculosi
Reacció en cadena de la polimerasa
Tuberculosis
Polymerase chain reaction
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spelling Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, Xpert®MTB/RIFCamprubí Ferrer, DanielGomila Grange, AinaGrijota Camino, Mª de los DesamparadosSoldevila-Boixader, LauraLuque, Maria J.Alcaide Fernández de Vega, FernandoDorca i Sargatal, JordiSantín Cerezales, MiguelTuberculosiReacció en cadena de la polimerasaTuberculosisPolymerase chain reactionCurrently, pulmonary tuberculosis (TB) isolation recommendations are based on serial sputum smear microscopy. To assess infectiousness of smear-negative/GeneXpert-positive (Sm-/GXpert+) pulmonary TB, we evaluated 511 contacts of pulmonary TB patients attended at a teaching hospital in Spain (2010-2018). There were no statistically significant differences in rates of Mycobacterium tuberculosis infection (46.2% contacts of smear-positive and 34.6% contacts of Sm-/GXpert+ pulmonary TB patients, p=0.112). Sm-/GXpert+ pulmonary TB poses a substantial risk of transmission of M. tuberculosis infection. Our results add evidence to support including Real-time Polymerase Chain Reaction (Xpert®MTB/RIF) in the work-up diagnosis of suspected pulmonary TB cases to make decisions on air-borne isolation.Elsevier2023202320202023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion3 p.application/pdfhttps://hdl.handle.net/2445/204083Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.jinf.2019.12.023Journal of Infection, 2020, vol. 80, num.3, p. 298-300https://doi.org/10.1016/j.jinf.2019.12.023cc-by-nc-nd (c) The British Infection Association, 2020http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2040832026-05-29T05:05:01Z
dc.title.none.fl_str_mv Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, Xpert®MTB/RIF
title Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, Xpert®MTB/RIF
spellingShingle Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, Xpert®MTB/RIF
Camprubí Ferrer, Daniel
Tuberculosi
Reacció en cadena de la polimerasa
Tuberculosis
Polymerase chain reaction
title_short Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, Xpert®MTB/RIF
title_full Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, Xpert®MTB/RIF
title_fullStr Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, Xpert®MTB/RIF
title_full_unstemmed Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, Xpert®MTB/RIF
title_sort Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, Xpert®MTB/RIF
dc.creator.none.fl_str_mv Camprubí Ferrer, Daniel
Gomila Grange, Aina
Grijota Camino, Mª de los Desamparados
Soldevila-Boixader, Laura
Luque, Maria J.
Alcaide Fernández de Vega, Fernando
Dorca i Sargatal, Jordi
Santín Cerezales, Miguel
author Camprubí Ferrer, Daniel
author_facet Camprubí Ferrer, Daniel
Gomila Grange, Aina
Grijota Camino, Mª de los Desamparados
Soldevila-Boixader, Laura
Luque, Maria J.
Alcaide Fernández de Vega, Fernando
Dorca i Sargatal, Jordi
Santín Cerezales, Miguel
author_role author
author2 Gomila Grange, Aina
Grijota Camino, Mª de los Desamparados
Soldevila-Boixader, Laura
Luque, Maria J.
Alcaide Fernández de Vega, Fernando
Dorca i Sargatal, Jordi
Santín Cerezales, Miguel
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Tuberculosi
Reacció en cadena de la polimerasa
Tuberculosis
Polymerase chain reaction
topic Tuberculosi
Reacció en cadena de la polimerasa
Tuberculosis
Polymerase chain reaction
description Currently, pulmonary tuberculosis (TB) isolation recommendations are based on serial sputum smear microscopy. To assess infectiousness of smear-negative/GeneXpert-positive (Sm-/GXpert+) pulmonary TB, we evaluated 511 contacts of pulmonary TB patients attended at a teaching hospital in Spain (2010-2018). There were no statistically significant differences in rates of Mycobacterium tuberculosis infection (46.2% contacts of smear-positive and 34.6% contacts of Sm-/GXpert+ pulmonary TB patients, p=0.112). Sm-/GXpert+ pulmonary TB poses a substantial risk of transmission of M. tuberculosis infection. Our results add evidence to support including Real-time Polymerase Chain Reaction (Xpert®MTB/RIF) in the work-up diagnosis of suspected pulmonary TB cases to make decisions on air-borne isolation.
publishDate 2020
dc.date.none.fl_str_mv 2020
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/204083
url https://hdl.handle.net/2445/204083
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.jinf.2019.12.023
Journal of Infection, 2020, vol. 80, num.3, p. 298-300
https://doi.org/10.1016/j.jinf.2019.12.023
dc.rights.none.fl_str_mv cc-by-nc-nd (c) The British Infection Association, 2020
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) The British Infection Association, 2020
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 3 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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