Abnormal features of human self-domestication in bipolardisorder

Bipolar disorder (BD) is a severe mental condition characterized by episodes of elevated mood and depression. Being a heritable condition, it features a complex genetic architecture, although it is not still clear how genes contribute to the onset and course of the disease. In this paper, we adopted...

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Detalles Bibliográficos
Autores: Benítez Burraco, Antonio, Hansen, Ethan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/169395
Acceso en línea:https://hdl.handle.net/11441/169395
https://doi.org/10.1111/ejn.15959
Access Level:acceso abierto
Palabra clave:bipolar disorder
differentially expressed genes
human evolution
neurotransmitter homeostasis
self-domestication
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spelling Abnormal features of human self-domestication in bipolardisorderBenítez Burraco, AntonioHansen, Ethanbipolar disorderdifferentially expressed geneshuman evolutionneurotransmitter homeostasisself-domesticationBipolar disorder (BD) is a severe mental condition characterized by episodes of elevated mood and depression. Being a heritable condition, it features a complex genetic architecture, although it is not still clear how genes contribute to the onset and course of the disease. In this paper, we adopted an evolutionary-genomic approach to this condition, focusing on changes occurred during human evolution as a source of our distinctive cognitive and behavioural phenotype. We show clinical evidence that the BD phenotype can be construed as an abnormal presentation of the human self-domestication phenotype. We further demonstrate that candidate genes for BD significantly overlap with candidates for mammal domestication and that this common set of genes is enriched in functions that are important for the BD phenotype, especially neurotransmitter homeostasis. Finally, we show that candidates for domestication are differentially expressed in brain regions involved in BD pathology, particularly, the hippocampus and the prefrontal cortex, which have been subject to recent changes in our species. Overall, this link between human self-domestication and BD should facilitate a better understanding of the BD etiopathology.Ministerio de Ciencia e Innovación PID2020-114516GB-I00WileyLengua Española, Lingüística y Teoría de la LiteraturaHUM972: BiolingüísticaMinisterio de Ciencia e Innovación (MICIN). España2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/169395https://doi.org/10.1111/ejn.15959reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésEJN. European Journal of Neuroscience, 57 (8), 1406-1431.PID2020-114516GB-I00https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.15959info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1693952026-06-17T12:51:07Z
dc.title.none.fl_str_mv Abnormal features of human self-domestication in bipolardisorder
title Abnormal features of human self-domestication in bipolardisorder
spellingShingle Abnormal features of human self-domestication in bipolardisorder
Benítez Burraco, Antonio
bipolar disorder
differentially expressed genes
human evolution
neurotransmitter homeostasis
self-domestication
title_short Abnormal features of human self-domestication in bipolardisorder
title_full Abnormal features of human self-domestication in bipolardisorder
title_fullStr Abnormal features of human self-domestication in bipolardisorder
title_full_unstemmed Abnormal features of human self-domestication in bipolardisorder
title_sort Abnormal features of human self-domestication in bipolardisorder
dc.creator.none.fl_str_mv Benítez Burraco, Antonio
Hansen, Ethan
author Benítez Burraco, Antonio
author_facet Benítez Burraco, Antonio
Hansen, Ethan
author_role author
author2 Hansen, Ethan
author2_role author
dc.contributor.none.fl_str_mv Lengua Española, Lingüística y Teoría de la Literatura
HUM972: Biolingüística
Ministerio de Ciencia e Innovación (MICIN). España
dc.subject.none.fl_str_mv bipolar disorder
differentially expressed genes
human evolution
neurotransmitter homeostasis
self-domestication
topic bipolar disorder
differentially expressed genes
human evolution
neurotransmitter homeostasis
self-domestication
description Bipolar disorder (BD) is a severe mental condition characterized by episodes of elevated mood and depression. Being a heritable condition, it features a complex genetic architecture, although it is not still clear how genes contribute to the onset and course of the disease. In this paper, we adopted an evolutionary-genomic approach to this condition, focusing on changes occurred during human evolution as a source of our distinctive cognitive and behavioural phenotype. We show clinical evidence that the BD phenotype can be construed as an abnormal presentation of the human self-domestication phenotype. We further demonstrate that candidate genes for BD significantly overlap with candidates for mammal domestication and that this common set of genes is enriched in functions that are important for the BD phenotype, especially neurotransmitter homeostasis. Finally, we show that candidates for domestication are differentially expressed in brain regions involved in BD pathology, particularly, the hippocampus and the prefrontal cortex, which have been subject to recent changes in our species. Overall, this link between human self-domestication and BD should facilitate a better understanding of the BD etiopathology.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/169395
https://doi.org/10.1111/ejn.15959
url https://hdl.handle.net/11441/169395
https://doi.org/10.1111/ejn.15959
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv EJN. European Journal of Neuroscience, 57 (8), 1406-1431.
PID2020-114516GB-I00
https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.15959
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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