4D Genome rewiring during oncogene-induced and replicative senescende

To understand the role of the extensive senescence-associated 3D genome reorganization, we generated genome-wide chromatin interaction maps, epigenome, replication-timing, whole-genome bisulfite sequencing, and gene expression profiles from cells entering replicative senescence (RS) or upon oncogene...

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Autores: Sati, Satish, Bonev, Boyan, Szabo, Quentin, Jost, Daniel, Bensadoun, Paul, Serra, Francois, Loubiere, Vincent, Papadopoulos, Giorgio Lucio, Rivera-Mulia, Juan-Carlos, Frisch, Lauriane, Bouret, Pauline, Castillo, David, Gelpí Buchaca, Josep Lluís, Orozco López, Modesto, Vaillant, Cedric, Pellestor, Franck, Bantignies, Frederic, Martí Renom, Marc A., Gilbert, David M., Lemaitre, Jean-Marc, Cavalli, Giacomo
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/172030
Acceso en línea:https://hdl.handle.net/2445/172030
Access Level:acceso abierto
Palabra clave:Oncogènesi
Cromatina
Epigenètica
Carcinogenesis
Chromatin
Epigenetics
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spelling 4D Genome rewiring during oncogene-induced and replicative senescendeSati, SatishBonev, BoyanSzabo, QuentinJost, DanielBensadoun, PaulSerra, FrancoisLoubiere, VincentPapadopoulos, Giorgio LucioRivera-Mulia, Juan-CarlosFrisch, LaurianeBouret, PaulineCastillo, DavidGelpí Buchaca, Josep LluísOrozco López, ModestoVaillant, CedricPellestor, FranckBantignies, FredericMartí Renom, Marc A.Gilbert, David M.Lemaitre, Jean-MarcCavalli, GiacomoOncogènesiCromatinaEpigenèticaCarcinogenesisChromatinEpigeneticsTo understand the role of the extensive senescence-associated 3D genome reorganization, we generated genome-wide chromatin interaction maps, epigenome, replication-timing, whole-genome bisulfite sequencing, and gene expression profiles from cells entering replicative senescence (RS) or upon oncogene-induced senescence (OIS). We identify senescence-associated heterochromatin domains (SAHDs). Differential intra- versus inter-SAHD interactions lead to the formation of senescence-associated heterochromatin foci (SAHFs) in OIS but not in RS. This OIS-specific configuration brings active genes located in genomic regions adjacent to SAHDs in close spatial proximity and favors their expression.We also identify DNMT1 as a factor that induces SAHFs by promoting HMGA2 expression. Upon DNMT1 depletion, OIS cells transition to a 3D genome conformation akin to that of cells in replicative senescence. These data show how multi-omics and imaging can identify critical features of RS and OIS and discover determinants of acute senescence and SAHF formation.Cell Press2020202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion17 p.application/pdfhttps://hdl.handle.net/2445/172030Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.molcel.2020.03.007Molecular Cell, 2020, vol. 78, num. 3, p. 522-538https://doi.org/10.1016/j.molcel.2020.03.007info:eu-repo/grantAgreement/EC/FP7/232947info:eu-repo/grantAgreement/EC/FP7/609989info:eu-repo/grantAgreement/EC/H2020/676556info:eu-repo/grantAgreement/EC/H2020/788972cc-by-nc-nd (c) Elsevier, 2020http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1720302026-05-29T05:05:01Z
dc.title.none.fl_str_mv 4D Genome rewiring during oncogene-induced and replicative senescende
title 4D Genome rewiring during oncogene-induced and replicative senescende
spellingShingle 4D Genome rewiring during oncogene-induced and replicative senescende
Sati, Satish
Oncogènesi
Cromatina
Epigenètica
Carcinogenesis
Chromatin
Epigenetics
title_short 4D Genome rewiring during oncogene-induced and replicative senescende
title_full 4D Genome rewiring during oncogene-induced and replicative senescende
title_fullStr 4D Genome rewiring during oncogene-induced and replicative senescende
title_full_unstemmed 4D Genome rewiring during oncogene-induced and replicative senescende
title_sort 4D Genome rewiring during oncogene-induced and replicative senescende
dc.creator.none.fl_str_mv Sati, Satish
Bonev, Boyan
Szabo, Quentin
Jost, Daniel
Bensadoun, Paul
Serra, Francois
Loubiere, Vincent
Papadopoulos, Giorgio Lucio
Rivera-Mulia, Juan-Carlos
Frisch, Lauriane
Bouret, Pauline
Castillo, David
Gelpí Buchaca, Josep Lluís
Orozco López, Modesto
Vaillant, Cedric
Pellestor, Franck
Bantignies, Frederic
Martí Renom, Marc A.
Gilbert, David M.
Lemaitre, Jean-Marc
Cavalli, Giacomo
author Sati, Satish
author_facet Sati, Satish
Bonev, Boyan
Szabo, Quentin
Jost, Daniel
Bensadoun, Paul
Serra, Francois
Loubiere, Vincent
Papadopoulos, Giorgio Lucio
Rivera-Mulia, Juan-Carlos
Frisch, Lauriane
Bouret, Pauline
Castillo, David
Gelpí Buchaca, Josep Lluís
Orozco López, Modesto
Vaillant, Cedric
Pellestor, Franck
Bantignies, Frederic
Martí Renom, Marc A.
Gilbert, David M.
Lemaitre, Jean-Marc
Cavalli, Giacomo
author_role author
author2 Bonev, Boyan
Szabo, Quentin
Jost, Daniel
Bensadoun, Paul
Serra, Francois
Loubiere, Vincent
Papadopoulos, Giorgio Lucio
Rivera-Mulia, Juan-Carlos
Frisch, Lauriane
Bouret, Pauline
Castillo, David
Gelpí Buchaca, Josep Lluís
Orozco López, Modesto
Vaillant, Cedric
Pellestor, Franck
Bantignies, Frederic
Martí Renom, Marc A.
Gilbert, David M.
Lemaitre, Jean-Marc
Cavalli, Giacomo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Oncogènesi
Cromatina
Epigenètica
Carcinogenesis
Chromatin
Epigenetics
topic Oncogènesi
Cromatina
Epigenètica
Carcinogenesis
Chromatin
Epigenetics
description To understand the role of the extensive senescence-associated 3D genome reorganization, we generated genome-wide chromatin interaction maps, epigenome, replication-timing, whole-genome bisulfite sequencing, and gene expression profiles from cells entering replicative senescence (RS) or upon oncogene-induced senescence (OIS). We identify senescence-associated heterochromatin domains (SAHDs). Differential intra- versus inter-SAHD interactions lead to the formation of senescence-associated heterochromatin foci (SAHFs) in OIS but not in RS. This OIS-specific configuration brings active genes located in genomic regions adjacent to SAHDs in close spatial proximity and favors their expression.We also identify DNMT1 as a factor that induces SAHFs by promoting HMGA2 expression. Upon DNMT1 depletion, OIS cells transition to a 3D genome conformation akin to that of cells in replicative senescence. These data show how multi-omics and imaging can identify critical features of RS and OIS and discover determinants of acute senescence and SAHF formation.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/172030
url https://hdl.handle.net/2445/172030
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.molcel.2020.03.007
Molecular Cell, 2020, vol. 78, num. 3, p. 522-538
https://doi.org/10.1016/j.molcel.2020.03.007
info:eu-repo/grantAgreement/EC/FP7/232947
info:eu-repo/grantAgreement/EC/FP7/609989
info:eu-repo/grantAgreement/EC/H2020/676556
info:eu-repo/grantAgreement/EC/H2020/788972
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier, 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier, 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17 p.
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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