Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS

© 2020 by the authors.

Detalles Bibliográficos
Autores: González-Mancha, Natalia, Mérida, Isabel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/215720
Acceso en línea:http://hdl.handle.net/10261/215720
Access Level:acceso abierto
Palabra clave:Diacylglycerol
Diacylglycerol kinase
SNX27
Retromer
Immune synapse
Intracellular trafficking
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spelling Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the ISGonzález-Mancha, NataliaMérida, IsabelDiacylglycerolDiacylglycerol kinaseSNX27RetromerImmune synapseIntracellular trafficking© 2020 by the authors.Recognition of antigens displayed on the surface of an antigen-presenting cell (APC) by T-cell receptors (TCR) of a T lymphocyte leads to the formation of a specialized contact between both cells named the immune synapse (IS). This highly organized structure ensures cell–cell communication and sustained T-cell activation. An essential lipid regulating T-cell activation is diacylglycerol (DAG), which accumulates at the cell–cell interface and mediates recruitment and activation of proteins involved in signaling and polarization. Formation of the IS requires rearrangement of the cytoskeleton, translocation of the microtubule-organizing center (MTOC) and vesicular compartments, and reorganization of signaling and adhesion molecules within the cell–cell junction. Among the multiple players involved in this polarized intracellular trafficking, we find sorting nexin 27 (SNX27). This protein translocates to the T cell–APC interface upon TCR activation, and it is suggested to facilitate the transport of cargoes toward this structure. Furthermore, its interaction with diacylglycerol kinase ζ (DGKζ), a negative regulator of DAG, sustains the precise modulation of this lipid and, thus, facilitates IS organization and signaling. Here, we review the role of SNX27, DAG metabolism, and their interplay in the control of T-cell activation and establishment of the IS.The work of Natalia González-Mancha received funding from the European Union Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 713673 and “La Caixa” Foundation (ID 100010434). The fellowship code is LCF/BQ/DI17/11620027. Research in Merida’s lab is funded by grants from the Spanish Association Against Cancer (AECC, CICPF18), Aplastic Anemia and MDS International Foundation (AAMDSIF, OPE01644), Spanish Ministry Economy and Competitiveness co-financed by the European Regional Development Fund (BFU2016-77207-R), and the Madrid regional government (IMMUNOTHERCAM Consortium S2010/BMD-2326) to I.M.Peer reviewedMultidisciplinary Digital Publishing InstituteEuropean CommissionMinisterio de Economía y Competitividad (España)Fundación la CaixaAsociación Española Contra el CáncerComunidad de MadridConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/215720reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/713673info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-77207-Rhttps://doi.org/10.3390/ijms21124254Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2157202026-05-22T06:33:51Z
dc.title.none.fl_str_mv Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS
title Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS
spellingShingle Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS
González-Mancha, Natalia
Diacylglycerol
Diacylglycerol kinase
SNX27
Retromer
Immune synapse
Intracellular trafficking
title_short Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS
title_full Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS
title_fullStr Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS
title_full_unstemmed Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS
title_sort Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS
dc.creator.none.fl_str_mv González-Mancha, Natalia
Mérida, Isabel
author González-Mancha, Natalia
author_facet González-Mancha, Natalia
Mérida, Isabel
author_role author
author2 Mérida, Isabel
author2_role author
dc.contributor.none.fl_str_mv European Commission
Ministerio de Economía y Competitividad (España)
Fundación la Caixa
Asociación Española Contra el Cáncer
Comunidad de Madrid
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Diacylglycerol
Diacylglycerol kinase
SNX27
Retromer
Immune synapse
Intracellular trafficking
topic Diacylglycerol
Diacylglycerol kinase
SNX27
Retromer
Immune synapse
Intracellular trafficking
description © 2020 by the authors.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/215720
url http://hdl.handle.net/10261/215720
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/713673
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-77207-R
https://doi.org/10.3390/ijms21124254
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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