Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density.

Abellaneda Pérez, Kilian; Vaqué Alcázar, Lídia; Perellón Alfonso, Ruben; Solé Padullés, Cristina; Bargalló Alabart, Núria; Salvador, Ricardo; Ruffini i Fores, Giulio; Nitsche, Michael A.; Pascual Leone, Álvaro, 1961-; Bartrés Faz, David

Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density.

Combining non-invasive brain stimulation (NIBS) with resting-state functional magnetic resonance imaging (rs-fMRI) is a promising approach to characterize and potentially optimize the brain networks subtending cognition that changes as a function of age. However, whether multifocal NIBS approaches a...

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Autores:	Abellaneda Pérez, Kilian, Vaqué Alcázar, Lídia, Perellón Alfonso, Ruben, Solé Padullés, Cristina, Bargalló Alabart, Núria, Salvador, Ricardo, Ruffini i Fores, Giulio, Nitsche, Michael A., Pascual Leone, Álvaro, 1961-, Bartrés Faz, David
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2021
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/195342
Acceso en línea:	https://hdl.handle.net/2445/195342
Access Level:	acceso abierto
Palabra clave:	Corrents elèctrics Estimulació elèctrica Estimulació del cervell Imatges per ressonància magnètica Electric currents Electric stimulation Brain stimulation Magnetic resonance imaging

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spelling	Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density.Abellaneda Pérez, KilianVaqué Alcázar, LídiaPerellón Alfonso, RubenSolé Padullés, CristinaBargalló Alabart, NúriaSalvador, RicardoRuffini i Fores, GiulioNitsche, Michael A.Pascual Leone, Álvaro, 1961-Bartrés Faz, DavidCorrents elèctricsEstimulació elèctricaEstimulació del cervellImatges per ressonància magnèticaElectric currentsElectric stimulationBrain stimulationMagnetic resonance imagingCombining non-invasive brain stimulation (NIBS) with resting-state functional magnetic resonance imaging (rs-fMRI) is a promising approach to characterize and potentially optimize the brain networks subtending cognition that changes as a function of age. However, whether multifocal NIBS approaches are able to modulate rs-fMRI brain dynamics in aged populations, and if these NIBS-induced changes are consistent with the simulated electric current distribution on the brain remains largely unknown. In the present investigation, thirty-one cognitively healthy older adults underwent two different multifocal real transcranial direct current stimulation (tDCS) conditions (C1 and C2) and a sham condition in a crossover design during a rs-fMRI acquisition. The real tDCS conditions were designed to electrically induce two distinct complex neural patterns, either targeting generalized frontoparietal cortical overactivity (C1) or a detachment between the frontal areas and the posteromedial cortex (C2). Data revealed that the two tDCS conditions modulated rs-fMRI differently. C1 increased the coactivation of multiple functional couplings as compared to sham, while a smaller number of connections increased in C1 as compared to C2. At the group level, C1-induced changes were topographically consistent with the calculated electric current density distribution. At the individual level, the extent of tDCS-induced rs-fMRI modulation in C1 was related with the magnitude of the simulated electric current density estimates. These results highlight that multifocal tDCS procedures can effectively change rs-fMRI neural functioning in advancing age, being the induced modulation consistent with the spatial distribution of the simulated electric current on the brain. Moreover, our data supports that individually tailoring NIBS-based interventions grounded on subject-specific structural data might be crucial to increase tDCS potential in future studies amongst older adultsFrontiers Media2023202320212023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/195342Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fnagi.2021.725013Frontiers in Aging Neuroscience, 2021, vol. 13, p. 725013https://doi.org/10.3389/fnagi.2021.725013cc-by (c) Abellaneda Pérez, Kilian et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1953422026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density.
title	Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density.
spellingShingle	Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density. Abellaneda Pérez, Kilian Corrents elèctrics Estimulació elèctrica Estimulació del cervell Imatges per ressonància magnètica Electric currents Electric stimulation Brain stimulation Magnetic resonance imaging
title_short	Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density.
title_full	Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density.
title_fullStr	Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density.
title_full_unstemmed	Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density.
title_sort	Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density.
dc.creator.none.fl_str_mv	Abellaneda Pérez, Kilian Vaqué Alcázar, Lídia Perellón Alfonso, Ruben Solé Padullés, Cristina Bargalló Alabart, Núria Salvador, Ricardo Ruffini i Fores, Giulio Nitsche, Michael A. Pascual Leone, Álvaro, 1961- Bartrés Faz, David
author	Abellaneda Pérez, Kilian
author_facet	Abellaneda Pérez, Kilian Vaqué Alcázar, Lídia Perellón Alfonso, Ruben Solé Padullés, Cristina Bargalló Alabart, Núria Salvador, Ricardo Ruffini i Fores, Giulio Nitsche, Michael A. Pascual Leone, Álvaro, 1961- Bartrés Faz, David
author_role	author
author2	Vaqué Alcázar, Lídia Perellón Alfonso, Ruben Solé Padullés, Cristina Bargalló Alabart, Núria Salvador, Ricardo Ruffini i Fores, Giulio Nitsche, Michael A. Pascual Leone, Álvaro, 1961- Bartrés Faz, David
author2_role	author author author author author author author author author
dc.subject.none.fl_str_mv	Corrents elèctrics Estimulació elèctrica Estimulació del cervell Imatges per ressonància magnètica Electric currents Electric stimulation Brain stimulation Magnetic resonance imaging
topic	Corrents elèctrics Estimulació elèctrica Estimulació del cervell Imatges per ressonància magnètica Electric currents Electric stimulation Brain stimulation Magnetic resonance imaging
description	Combining non-invasive brain stimulation (NIBS) with resting-state functional magnetic resonance imaging (rs-fMRI) is a promising approach to characterize and potentially optimize the brain networks subtending cognition that changes as a function of age. However, whether multifocal NIBS approaches are able to modulate rs-fMRI brain dynamics in aged populations, and if these NIBS-induced changes are consistent with the simulated electric current distribution on the brain remains largely unknown. In the present investigation, thirty-one cognitively healthy older adults underwent two different multifocal real transcranial direct current stimulation (tDCS) conditions (C1 and C2) and a sham condition in a crossover design during a rs-fMRI acquisition. The real tDCS conditions were designed to electrically induce two distinct complex neural patterns, either targeting generalized frontoparietal cortical overactivity (C1) or a detachment between the frontal areas and the posteromedial cortex (C2). Data revealed that the two tDCS conditions modulated rs-fMRI differently. C1 increased the coactivation of multiple functional couplings as compared to sham, while a smaller number of connections increased in C1 as compared to C2. At the group level, C1-induced changes were topographically consistent with the calculated electric current density distribution. At the individual level, the extent of tDCS-induced rs-fMRI modulation in C1 was related with the magnitude of the simulated electric current density estimates. These results highlight that multifocal tDCS procedures can effectively change rs-fMRI neural functioning in advancing age, being the induced modulation consistent with the spatial distribution of the simulated electric current on the brain. Moreover, our data supports that individually tailoring NIBS-based interventions grounded on subject-specific structural data might be crucial to increase tDCS potential in future studies amongst older adults
publishDate	2021
dc.date.none.fl_str_mv	2021 2023 2023 2023
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/195342
url	https://hdl.handle.net/2445/195342
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.3389/fnagi.2021.725013 Frontiers in Aging Neuroscience, 2021, vol. 13, p. 725013 https://doi.org/10.3389/fnagi.2021.725013
dc.rights.none.fl_str_mv	cc-by (c) Abellaneda Pérez, Kilian et al., 2021 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by (c) Abellaneda Pérez, Kilian et al., 2021 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	14 p. application/pdf
dc.publisher.none.fl_str_mv	Frontiers Media
publisher.none.fl_str_mv	Frontiers Media
dc.source.none.fl_str_mv	Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,811543

Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density.

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