Unraveling the impact of prenatal air pollution for neonatal brain maturation

Early brain development is highly sensitive to environmental influences. While prenatal exposure to airborne particulate matter (PM2.5) has been broadly associated with harmful effects, PM2.5 also contains trace elements such as iron, copper and zinc, which are essential for brain growth. This study...

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Autores: Pujol, J, Martinez-Vilavella, G, Gómez-Herrera, L, Rivas, I, Gómez-Roig, MD, Llurba, E, Blanco-Hinojo, L, Cirach, M, Persavento, C, Querol, X, Gascón, M, Foraster, M, Gispert, JD, Falcón, C, Deus, J, Dadvand, P, Sunyer, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p20200
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20200
Access Level:acceso abierto
Palabra clave:Particulate matter
Neonates
Myelination
Brain development
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spelling Unraveling the impact of prenatal air pollution for neonatal brain maturationPujol, JMartinez-Vilavella, GGómez-Herrera, LRivas, IGómez-Roig, MDLlurba, EBlanco-Hinojo, LCirach, MPersavento, CQuerol, XGascón, MForaster, MGispert, JDFalcón, CDeus, JDadvand, PSunyer, JParticulate matterNeonatesMyelinationBrain developmentEarly brain development is highly sensitive to environmental influences. While prenatal exposure to airborne particulate matter (PM2.5) has been broadly associated with harmful effects, PM2.5 also contains trace elements such as iron, copper and zinc, which are essential for brain growth. This study examined both the overall impact of prenatal PM2.5 exposure and the specific role of these trace elements on neonatal myelinated white matter-a key marker of brain maturation. This population-based study included 93 neonates recruited from three major hospitals in Barcelona (2018-2021). PM2.5 exposure was estimated for the embryonic and late fetal periods using land-use regression models incorporating time-weighted maternal mobility data. MRI was performed at 29 days postnatally. Global myelinated white matter was manually segmented, and automated cortical myelination measures were obtained in 85 cases. Associations were examined using linear regression models with and without adjustment for potential confounders. Higher prenatal PM2.5 exposure was associated with lower myelinated white matter content. Trace elements showed a similar pattern, but their associations became nonsignificant after adjusting for overall PM2.5 exposure. The findings suggest that prenatal air pollution exposure may delay early myelination. Moreover, no specific associations were identified for iron, copper, or zinc. However, given the dynamic nature of white matter maturation, such delays may not necessarily be detrimental. This study underscores the impact of environmental factors on neonatal brain development and the importance of stringent air quality policies, while emphasizing the need for longitudinal research to assess long-term cognitive and behavioral outcomes.PERGAMON-ELSEVIER SCIENCE LTD2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20200ENVIRONMENT INTERNATIONALISSN: 01604120ISSNe: 18736750reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p202002026-06-14T12:41:47Z
dc.title.none.fl_str_mv Unraveling the impact of prenatal air pollution for neonatal brain maturation
title Unraveling the impact of prenatal air pollution for neonatal brain maturation
spellingShingle Unraveling the impact of prenatal air pollution for neonatal brain maturation
Pujol, J
Particulate matter
Neonates
Myelination
Brain development
title_short Unraveling the impact of prenatal air pollution for neonatal brain maturation
title_full Unraveling the impact of prenatal air pollution for neonatal brain maturation
title_fullStr Unraveling the impact of prenatal air pollution for neonatal brain maturation
title_full_unstemmed Unraveling the impact of prenatal air pollution for neonatal brain maturation
title_sort Unraveling the impact of prenatal air pollution for neonatal brain maturation
dc.creator.none.fl_str_mv Pujol, J
Martinez-Vilavella, G
Gómez-Herrera, L
Rivas, I
Gómez-Roig, MD
Llurba, E
Blanco-Hinojo, L
Cirach, M
Persavento, C
Querol, X
Gascón, M
Foraster, M
Gispert, JD
Falcón, C
Deus, J
Dadvand, P
Sunyer, J
author Pujol, J
author_facet Pujol, J
Martinez-Vilavella, G
Gómez-Herrera, L
Rivas, I
Gómez-Roig, MD
Llurba, E
Blanco-Hinojo, L
Cirach, M
Persavento, C
Querol, X
Gascón, M
Foraster, M
Gispert, JD
Falcón, C
Deus, J
Dadvand, P
Sunyer, J
author_role author
author2 Martinez-Vilavella, G
Gómez-Herrera, L
Rivas, I
Gómez-Roig, MD
Llurba, E
Blanco-Hinojo, L
Cirach, M
Persavento, C
Querol, X
Gascón, M
Foraster, M
Gispert, JD
Falcón, C
Deus, J
Dadvand, P
Sunyer, J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Particulate matter
Neonates
Myelination
Brain development
topic Particulate matter
Neonates
Myelination
Brain development
description Early brain development is highly sensitive to environmental influences. While prenatal exposure to airborne particulate matter (PM2.5) has been broadly associated with harmful effects, PM2.5 also contains trace elements such as iron, copper and zinc, which are essential for brain growth. This study examined both the overall impact of prenatal PM2.5 exposure and the specific role of these trace elements on neonatal myelinated white matter-a key marker of brain maturation. This population-based study included 93 neonates recruited from three major hospitals in Barcelona (2018-2021). PM2.5 exposure was estimated for the embryonic and late fetal periods using land-use regression models incorporating time-weighted maternal mobility data. MRI was performed at 29 days postnatally. Global myelinated white matter was manually segmented, and automated cortical myelination measures were obtained in 85 cases. Associations were examined using linear regression models with and without adjustment for potential confounders. Higher prenatal PM2.5 exposure was associated with lower myelinated white matter content. Trace elements showed a similar pattern, but their associations became nonsignificant after adjusting for overall PM2.5 exposure. The findings suggest that prenatal air pollution exposure may delay early myelination. Moreover, no specific associations were identified for iron, copper, or zinc. However, given the dynamic nature of white matter maturation, such delays may not necessarily be detrimental. This study underscores the impact of environmental factors on neonatal brain development and the importance of stringent air quality policies, while emphasizing the need for longitudinal research to assess long-term cognitive and behavioral outcomes.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20200
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20200
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv PERGAMON-ELSEVIER SCIENCE LTD
publisher.none.fl_str_mv PERGAMON-ELSEVIER SCIENCE LTD
dc.source.none.fl_str_mv ENVIRONMENT INTERNATIONAL
ISSN: 01604120
ISSNe: 18736750
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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