Conduction system pacing vs. biventricular pacing in patients with ventricular dysfunction and AV block

Pujol López, Margarida; Jiménez Arjona, Rafael; Guasch i Casany, Eduard; Borràs, Roger; Doltra, Adelina; Vázquez Calvo, Sara; Roca Luque, Ivo; Garre Anguera de Sojo, Paz; Ferró, Elisenda; Niebla Bellido, Mireia; Carro, Esther; Puente, Jose L.; Uribe, Laura; Invers, Eric; Castel Lavilla, Maria Àngels; Arbelo, Elena; Sitges Carreño, Marta; Mont Girbau, Lluís; Tolosana, José M. (José María)

Conduction system pacing vs. biventricular pacing in patients with ventricular dysfunction and AV block

Background: It is unknown whether His-Purkinje conduction system pacing (HPCSP), as either His bundle or left bundle branch pacing, could be an alternative to cardiac resynchronization therapy (BiVCRT) for patients with left ventricular dysfunction needing ventricular pacing due to atrioventricular...

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Autores:	Pujol López, Margarida, Jiménez Arjona, Rafael, Guasch i Casany, Eduard, Borràs, Roger, Doltra, Adelina, Vázquez Calvo, Sara, Roca Luque, Ivo, Garre Anguera de Sojo, Paz, Ferró, Elisenda, Niebla Bellido, Mireia, Carro, Esther, Puente, Jose L., Uribe, Laura, Invers, Eric, Castel Lavilla, Maria Àngels, Arbelo, Elena, Sitges Carreño, Marta, Mont Girbau, Lluís, Tolosana, José M. (José María)
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/216113
Acceso en línea:	https://hdl.handle.net/2445/216113
Access Level:	acceso abierto
Palabra clave:	Insuficiència cardíaca Ventricles cardíacs Avaluació de resultats (Assistència mèdica) Efectes secundaris Heart failure Ventricle of heart Outcome assessment (Medical care) Side effects

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spelling	Conduction system pacing vs. biventricular pacing in patients with ventricular dysfunction and AV blockPujol López, MargaridaJiménez Arjona, RafaelGuasch i Casany, EduardBorràs, RogerDoltra, AdelinaVázquez Calvo, SaraRoca Luque, IvoGarre Anguera de Sojo, PazFerró, ElisendaNiebla Bellido, MireiaCarro, EstherPuente, Jose L.Uribe, LauraInvers, EricCastel Lavilla, Maria ÀngelsArbelo, ElenaSitges Carreño, MartaMont Girbau, LluísTolosana, José M. (José María)Insuficiència cardíacaVentricles cardíacsAvaluació de resultats (Assistència mèdica)Efectes secundarisHeart failureVentricle of heartOutcome assessment (Medical care)Side effectsBackground: It is unknown whether His-Purkinje conduction system pacing (HPCSP), as either His bundle or left bundle branch pacing, could be an alternative to cardiac resynchronization therapy (BiVCRT) for patients with left ventricular dysfunction needing ventricular pacing due to atrioventricular block. The aim of the study is to compare the echocardiographic response and clinical improvement between HPCSP and BiVCRT. Methods: Consecutive patients who successfully received HPCSP were compared with a historical cohort of BiVCRT patients. Patients were 1:1 matched by age, LVEF, atrial fibrillation, renal function and cardiomyopathy type. Responders were defined as patients who survived, did not require heart transplantation and increased LVEF ≥5 points at 6-month follow-up. Results: HPCSP was successfully achieved in 92.5% (25/27) of patients. During follow-up, 8% (2/25) of HPCSP patients died and 4% (1/25) received a heart transplant, whereas 4% (1/25) of those in the BiVCRT cohort died. LVEF improvement was 10% ± 8% HPCSP versus 7% ± 5% BiVCRT (p = .24), and the percentage of responders was 76% (19/25) HPCSP versus 64% (16/25) BiVCRT (p = .33). Among survivors, the percentage of patients who improved from baseline II-IV mitral regurgitation (MR) to 0-I MR was 9/11 (82%) versus 2/8 (25%) (p = .02). Compared to those with BiVCRT, patients with HPCSP achieved better NYHA improvement: 1 point versus 0.5 (OR 0.34; p = .02). Conclusion: HPCSP in patients with LVEF ≤45% and atrioventricular block improved the LVEF and induced a response similar to that of BiVCRT. HPCSP significantly improved MR and NYHA functional class. HPCSP may be an alternative to BiVCRT in these patients. (Figure 1. Central Illustration). [Figure: see text].Wiley2024202420222024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/216113Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1111/pace.14535Pace-Pacing and Clinical Electrophysiology, 2022, vol. 45, num.9, p. 1115-1123https://doi.org/10.1111/pace.14535cc-by-nc-nd (c) Pujol López, Margarida et al., 2022http://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2161132026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Conduction system pacing vs. biventricular pacing in patients with ventricular dysfunction and AV block
title	Conduction system pacing vs. biventricular pacing in patients with ventricular dysfunction and AV block
spellingShingle	Conduction system pacing vs. biventricular pacing in patients with ventricular dysfunction and AV block Pujol López, Margarida Insuficiència cardíaca Ventricles cardíacs Avaluació de resultats (Assistència mèdica) Efectes secundaris Heart failure Ventricle of heart Outcome assessment (Medical care) Side effects
title_short	Conduction system pacing vs. biventricular pacing in patients with ventricular dysfunction and AV block
title_full	Conduction system pacing vs. biventricular pacing in patients with ventricular dysfunction and AV block
title_fullStr	Conduction system pacing vs. biventricular pacing in patients with ventricular dysfunction and AV block
title_full_unstemmed	Conduction system pacing vs. biventricular pacing in patients with ventricular dysfunction and AV block
title_sort	Conduction system pacing vs. biventricular pacing in patients with ventricular dysfunction and AV block
dc.creator.none.fl_str_mv	Pujol López, Margarida Jiménez Arjona, Rafael Guasch i Casany, Eduard Borràs, Roger Doltra, Adelina Vázquez Calvo, Sara Roca Luque, Ivo Garre Anguera de Sojo, Paz Ferró, Elisenda Niebla Bellido, Mireia Carro, Esther Puente, Jose L. Uribe, Laura Invers, Eric Castel Lavilla, Maria Àngels Arbelo, Elena Sitges Carreño, Marta Mont Girbau, Lluís Tolosana, José M. (José María)
author	Pujol López, Margarida
author_facet	Pujol López, Margarida Jiménez Arjona, Rafael Guasch i Casany, Eduard Borràs, Roger Doltra, Adelina Vázquez Calvo, Sara Roca Luque, Ivo Garre Anguera de Sojo, Paz Ferró, Elisenda Niebla Bellido, Mireia Carro, Esther Puente, Jose L. Uribe, Laura Invers, Eric Castel Lavilla, Maria Àngels Arbelo, Elena Sitges Carreño, Marta Mont Girbau, Lluís Tolosana, José M. (José María)
author_role	author
author2	Jiménez Arjona, Rafael Guasch i Casany, Eduard Borràs, Roger Doltra, Adelina Vázquez Calvo, Sara Roca Luque, Ivo Garre Anguera de Sojo, Paz Ferró, Elisenda Niebla Bellido, Mireia Carro, Esther Puente, Jose L. Uribe, Laura Invers, Eric Castel Lavilla, Maria Àngels Arbelo, Elena Sitges Carreño, Marta Mont Girbau, Lluís Tolosana, José M. (José María)
author2_role	author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Insuficiència cardíaca Ventricles cardíacs Avaluació de resultats (Assistència mèdica) Efectes secundaris Heart failure Ventricle of heart Outcome assessment (Medical care) Side effects
topic	Insuficiència cardíaca Ventricles cardíacs Avaluació de resultats (Assistència mèdica) Efectes secundaris Heart failure Ventricle of heart Outcome assessment (Medical care) Side effects
description	Background: It is unknown whether His-Purkinje conduction system pacing (HPCSP), as either His bundle or left bundle branch pacing, could be an alternative to cardiac resynchronization therapy (BiVCRT) for patients with left ventricular dysfunction needing ventricular pacing due to atrioventricular block. The aim of the study is to compare the echocardiographic response and clinical improvement between HPCSP and BiVCRT. Methods: Consecutive patients who successfully received HPCSP were compared with a historical cohort of BiVCRT patients. Patients were 1:1 matched by age, LVEF, atrial fibrillation, renal function and cardiomyopathy type. Responders were defined as patients who survived, did not require heart transplantation and increased LVEF ≥5 points at 6-month follow-up. Results: HPCSP was successfully achieved in 92.5% (25/27) of patients. During follow-up, 8% (2/25) of HPCSP patients died and 4% (1/25) received a heart transplant, whereas 4% (1/25) of those in the BiVCRT cohort died. LVEF improvement was 10% ± 8% HPCSP versus 7% ± 5% BiVCRT (p = .24), and the percentage of responders was 76% (19/25) HPCSP versus 64% (16/25) BiVCRT (p = .33). Among survivors, the percentage of patients who improved from baseline II-IV mitral regurgitation (MR) to 0-I MR was 9/11 (82%) versus 2/8 (25%) (p = .02). Compared to those with BiVCRT, patients with HPCSP achieved better NYHA improvement: 1 point versus 0.5 (OR 0.34; p = .02). Conclusion: HPCSP in patients with LVEF ≤45% and atrioventricular block improved the LVEF and induced a response similar to that of BiVCRT. HPCSP significantly improved MR and NYHA functional class. HPCSP may be an alternative to BiVCRT in these patients. (Figure 1. Central Illustration). [Figure: see text].
publishDate	2022
dc.date.none.fl_str_mv	2022 2024 2024 2024
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/216113
url	https://hdl.handle.net/2445/216113
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1111/pace.14535 Pace-Pacing and Clinical Electrophysiology, 2022, vol. 45, num.9, p. 1115-1123 https://doi.org/10.1111/pace.14535
dc.rights.none.fl_str_mv	cc-by-nc-nd (c) Pujol López, Margarida et al., 2022 http://creativecommons.org/licenses/by-nc-nd/4.0 info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by-nc-nd (c) Pujol López, Margarida et al., 2022 http://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	9 p. application/pdf application/pdf
dc.publisher.none.fl_str_mv	Wiley
publisher.none.fl_str_mv	Wiley
dc.source.none.fl_str_mv	Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Conduction system pacing vs. biventricular pacing in patients with ventricular dysfunction and AV block

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