The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.

Braasch, Ingo; Gehrke, Andrew R.; Smith, Jeramiah J.; Kawasaki, Kazuhiko; Manousaki, Tereza; Pasquier, Jeremy; Amores, Angel; Desvignes, Thomas; Batzel, Peter; Catchen, Julian M.; Berlin, Aaron M.; Campbell, Michael S.; Barrell, Daniel; Martin, Kyle J.; Mulley, John F.; Ravi, Vydianathan; Lee, Alison P.; Nakamura, Tetsuya; Chalopin, Domitille; Fan, Shaohua; Wcisel, Dustin; Cañestro García, Cristian; Sydes, Jason; Beaudry, Felix E.; Sun, Yi; Hertel, Jana; Beam, Michael J.; Fasold, Mario; Ishiyama, Mikio; Johnson, Jeremy; Kehr, Steffi; Lara, Marcia; Letaw, John H.; Litman, Gary W.; Litman, Ronda T.; Mikami, Masato; Ota, Tatsuya; Saha, Nil Ratan; Williams, Louise; Stadler, Peter F.

The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.

To connect human biology to fish biomedical models, we sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD). The slowly evolving gar genome has conserved in content and size many entire chromosomes from bony vertebra...

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Autores:	Braasch, Ingo, Gehrke, Andrew R., Smith, Jeramiah J., Kawasaki, Kazuhiko, Manousaki, Tereza, Pasquier, Jeremy, Amores, Angel, Desvignes, Thomas, Batzel, Peter, Catchen, Julian M., Berlin, Aaron M., Campbell, Michael S., Barrell, Daniel, Martin, Kyle J., Mulley, John F., Ravi, Vydianathan, Lee, Alison P., Nakamura, Tetsuya, Chalopin, Domitille, Fan, Shaohua, Wcisel, Dustin, Cañestro García, Cristian, Sydes, Jason, Beaudry, Felix E., Sun, Yi, Hertel, Jana, Beam, Michael J., Fasold, Mario, Ishiyama, Mikio, Johnson, Jeremy, Kehr, Steffi, Lara, Marcia, Letaw, John H., Litman, Gary W., Litman, Ronda T., Mikami, Masato, Ota, Tatsuya, Saha, Nil Ratan, Williams, Louise, Stadler, Peter F.
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2016
País:	España
Institución:	Universidad de Barcelona
Repositorio:	Dipòsit Digital de la UB
OAI Identifier:	oai:diposit.ub.edu:2445/110854
Acceso en línea:	https://hdl.handle.net/2445/110854
Access Level:	acceso abierto
Palabra clave:	Teleostis Models animals en la investigació Genomes Teleostei Animal models in research

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spelling	The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.Braasch, IngoGehrke, Andrew R.Smith, Jeramiah J.Kawasaki, KazuhikoManousaki, TerezaPasquier, JeremyAmores, AngelDesvignes, ThomasBatzel, PeterCatchen, Julian M.Berlin, Aaron M.Campbell, Michael S.Barrell, DanielMartin, Kyle J.Mulley, John F.Ravi, VydianathanLee, Alison P.Nakamura, TetsuyaChalopin, DomitilleFan, ShaohuaWcisel, DustinCañestro García, CristianSydes, JasonBeaudry, Felix E.Sun, YiHertel, JanaBeam, Michael J.Fasold, MarioIshiyama, MikioJohnson, JeremyKehr, SteffiLara, MarciaLetaw, John H.Litman, Gary W.Litman, Ronda T.Mikami, MasatoOta, TatsuyaSaha, Nil RatanWilliams, LouiseStadler, Peter F.TeleostisModels animals en la investigacióGenomesTeleosteiAnimal models in researchGenomesTo connect human biology to fish biomedical models, we sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD). The slowly evolving gar genome has conserved in content and size many entire chromosomes from bony vertebrate ancestors. Gar bridges teleosts to tetrapods by illuminating the evolution of immunity, mineralization and development (mediated, for example, by Hox, ParaHox and microRNA genes). Numerous conserved noncoding elements (CNEs; often cis regulatory) undetectable in direct human-teleost comparisons become apparent using gar: functional studies uncovered conserved roles for such cryptic CNEs, facilitating annotation of sequences identified in human genome-wide association studies. Transcriptomic analyses showed that the sums of expression domains and expression levels for duplicated teleost genes often approximate the patterns and levels of expression for gar genes, consistent with subfunctionalization. The gar genome provides a resource for understanding evolution after genome duplication, the origin of vertebrate genomes and the function of human regulatory sequences.Nature Publishing Group2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/110854Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/ng.3526Nature Genetics, 2016, vol. 48, p. 427-437https://doi.org/10.1038/ng.3526info:eu-repo/grantAgreement/EC/FP7/268513cc-by-nc-sa (c) Braasch, I. et al., 2016http://creativecommons.org/licenses/by-nc-sa/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1108542026-05-27T06:46:51Z
dc.title.none.fl_str_mv	The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.
title	The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.
spellingShingle	The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Braasch, Ingo Teleostis Models animals en la investigació Genomes Teleostei Animal models in research Genomes
title_short	The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.
title_full	The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.
title_fullStr	The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.
title_full_unstemmed	The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.
title_sort	The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.
dc.creator.none.fl_str_mv	Braasch, Ingo Gehrke, Andrew R. Smith, Jeramiah J. Kawasaki, Kazuhiko Manousaki, Tereza Pasquier, Jeremy Amores, Angel Desvignes, Thomas Batzel, Peter Catchen, Julian M. Berlin, Aaron M. Campbell, Michael S. Barrell, Daniel Martin, Kyle J. Mulley, John F. Ravi, Vydianathan Lee, Alison P. Nakamura, Tetsuya Chalopin, Domitille Fan, Shaohua Wcisel, Dustin Cañestro García, Cristian Sydes, Jason Beaudry, Felix E. Sun, Yi Hertel, Jana Beam, Michael J. Fasold, Mario Ishiyama, Mikio Johnson, Jeremy Kehr, Steffi Lara, Marcia Letaw, John H. Litman, Gary W. Litman, Ronda T. Mikami, Masato Ota, Tatsuya Saha, Nil Ratan Williams, Louise Stadler, Peter F.
author	Braasch, Ingo
author_facet	Braasch, Ingo Gehrke, Andrew R. Smith, Jeramiah J. Kawasaki, Kazuhiko Manousaki, Tereza Pasquier, Jeremy Amores, Angel Desvignes, Thomas Batzel, Peter Catchen, Julian M. Berlin, Aaron M. Campbell, Michael S. Barrell, Daniel Martin, Kyle J. Mulley, John F. Ravi, Vydianathan Lee, Alison P. Nakamura, Tetsuya Chalopin, Domitille Fan, Shaohua Wcisel, Dustin Cañestro García, Cristian Sydes, Jason Beaudry, Felix E. Sun, Yi Hertel, Jana Beam, Michael J. Fasold, Mario Ishiyama, Mikio Johnson, Jeremy Kehr, Steffi Lara, Marcia Letaw, John H. Litman, Gary W. Litman, Ronda T. Mikami, Masato Ota, Tatsuya Saha, Nil Ratan Williams, Louise Stadler, Peter F.
author_role	author
author2	Gehrke, Andrew R. Smith, Jeramiah J. Kawasaki, Kazuhiko Manousaki, Tereza Pasquier, Jeremy Amores, Angel Desvignes, Thomas Batzel, Peter Catchen, Julian M. Berlin, Aaron M. Campbell, Michael S. Barrell, Daniel Martin, Kyle J. Mulley, John F. Ravi, Vydianathan Lee, Alison P. Nakamura, Tetsuya Chalopin, Domitille Fan, Shaohua Wcisel, Dustin Cañestro García, Cristian Sydes, Jason Beaudry, Felix E. Sun, Yi Hertel, Jana Beam, Michael J. Fasold, Mario Ishiyama, Mikio Johnson, Jeremy Kehr, Steffi Lara, Marcia Letaw, John H. Litman, Gary W. Litman, Ronda T. Mikami, Masato Ota, Tatsuya Saha, Nil Ratan Williams, Louise Stadler, Peter F.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Teleostis Models animals en la investigació Genomes Teleostei Animal models in research Genomes
topic	Teleostis Models animals en la investigació Genomes Teleostei Animal models in research Genomes
description	To connect human biology to fish biomedical models, we sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD). The slowly evolving gar genome has conserved in content and size many entire chromosomes from bony vertebrate ancestors. Gar bridges teleosts to tetrapods by illuminating the evolution of immunity, mineralization and development (mediated, for example, by Hox, ParaHox and microRNA genes). Numerous conserved noncoding elements (CNEs; often cis regulatory) undetectable in direct human-teleost comparisons become apparent using gar: functional studies uncovered conserved roles for such cryptic CNEs, facilitating annotation of sequences identified in human genome-wide association studies. Transcriptomic analyses showed that the sums of expression domains and expression levels for duplicated teleost genes often approximate the patterns and levels of expression for gar genes, consistent with subfunctionalization. The gar genome provides a resource for understanding evolution after genome duplication, the origin of vertebrate genomes and the function of human regulatory sequences.
publishDate	2016
dc.date.none.fl_str_mv	2016
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/110854
url	https://hdl.handle.net/2445/110854
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1038/ng.3526 Nature Genetics, 2016, vol. 48, p. 427-437 https://doi.org/10.1038/ng.3526 info:eu-repo/grantAgreement/EC/FP7/268513
dc.rights.none.fl_str_mv	cc-by-nc-sa (c) Braasch, I. et al., 2016 http://creativecommons.org/licenses/by-nc-sa/3.0/es info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by-nc-sa (c) Braasch, I. et al., 2016 http://creativecommons.org/licenses/by-nc-sa/3.0/es
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Nature Publishing Group
publisher.none.fl_str_mv	Nature Publishing Group
dc.source.none.fl_str_mv	Articles publicats en revistes (Genètica, Microbiologia i Estadística) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona
instname_str	Universidad de Barcelona
reponame_str	Dipòsit Digital de la UB
collection	Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.

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