A retrospective validation of CanAssist Breast in European early-stage breast cancer patient cohort

Hormone-receptor positive; Chemotherapy; Early-stage breast cancer

Detalles Bibliográficos
Autores: Gunda, Aparna, Basavaraj, Chetana, Pradhan, Prakash Chandra, Adinarayan, Manjula, Kolli, Ramu, Siraganahalli Eshwaraiah, Mallikarjuna, Ruiz Pace, Fiorella, Gómez Pardo, Patricia, Jiménez Flores, José Antonio, Saura Manich, Cristina, Peg, Vicente
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/7897
Acceso en línea:https://hdl.handle.net/11351/7897
Access Level:acceso abierto
Palabra clave:Mama - Càncer - Prognosi
Diagnòstic immunohistoquímic
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::/diagnosis
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::/diagnóstico
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spelling A retrospective validation of CanAssist Breast in European early-stage breast cancer patient cohortGunda, AparnaBasavaraj, ChetanaPradhan, Prakash ChandraAdinarayan, ManjulaKolli, RamuSiraganahalli Eshwaraiah, MallikarjunaRuiz Pace, FiorellaGómez Pardo, PatriciaJiménez Flores, José AntonioSaura Manich, CristinaPeg, VicenteMama - Càncer - PrognosiDiagnòstic immunohistoquímicDISEASES::Neoplasms::Neoplasms by Site::Breast NeoplasmsOther subheadings::Other subheadings::/diagnosisENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mamaOtros calificadores::Otros calificadores::/diagnósticoHormone-receptor positive; Chemotherapy; Early-stage breast cancerReceptor de hormonas positivo; Quimioterapia; Cáncer de mama en fase inicialReceptor d'hormones positiu; Quimioteràpia; Càncer de mama en fase inicialCanAssist Breast (CAB), a prognostic test uses immunohistochemistry (IHC) approach coupled with artificial intelligence-based machine learning algorithm for prognosis of early-stage hormone-receptor positive, HER2/neu negative breast cancer patients. It was developed and validated in an Indian cohort. Here we report the first blinded validation of CAB in a multi-country European patient cohort. FFPE tumor samples from 864 patients were obtained from-Spain, Italy, Austria, and Germany. IHC was performed on these samples, followed by recurrence risk score prediction. The outcomes were obtained from medical records. The performance of CAB was analyzed by hazard ratios (HR) and Kaplan Meier curves. CAB stratified European cohort (n = 864) into distinct low- and high-risk groups for recurrence (P < 0.0001) with HR of 3.32 (1.85–5.93) like that of mixed (India, USA, and Europe) (n = 1974), 3.43 (2.34–4.93) and Indian cohort (n = 925), 3.09 (1.83–5.21). CAB provided significant prognostic information (P < 0.0001) in women aged ≤ 50 (HR: 4.42 (1.58–12.3), P < 0.0001) and >50 years (HR: 2.93 (1.44–5.96), P = 0.0002). CAB had an HR of 2.57 (1.26–5.26), P = 0.01) in women with N1 disease. CAB stratified significantly higher proportions (77%) as low-risk over IHC4 (55%) (P < 0.0001). Additionally, 82% of IHC4 intermediate-risk patients were stratified as low-risk by CAB. Accurate risk stratification of European patients by CAB coupled with its similar performance inIndian patients shows that CAB is robust and functions independent of ethnic differences. CAB can potentially prevent overtreatment in a greater number of patients compared to IHC4 demonstrating its usefulness for adjuvant systemic therapy planning in European breast cancer patients.ElsevierInstitut Català de la Salut[Gunda A, Basavaraj C, Serkad V CP, Adinarayan M, Kolli R, Siraganahalli Eshwaraiah M] OncoStem Diagnostics, Bengaluru, Karnataka, India. [Saura C, Ruiz F, Gomez P, Peg V, Jimenez J] Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d'Hebron Institute of Oncology (VHIO), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7897Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésThe Breast;63https://doi.org/10.1016/j.breast.2022.02.010Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/78972026-06-12T09:38:37Z
dc.title.none.fl_str_mv A retrospective validation of CanAssist Breast in European early-stage breast cancer patient cohort
title A retrospective validation of CanAssist Breast in European early-stage breast cancer patient cohort
spellingShingle A retrospective validation of CanAssist Breast in European early-stage breast cancer patient cohort
Gunda, Aparna
Mama - Càncer - Prognosi
Diagnòstic immunohistoquímic
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::/diagnosis
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::/diagnóstico
title_short A retrospective validation of CanAssist Breast in European early-stage breast cancer patient cohort
title_full A retrospective validation of CanAssist Breast in European early-stage breast cancer patient cohort
title_fullStr A retrospective validation of CanAssist Breast in European early-stage breast cancer patient cohort
title_full_unstemmed A retrospective validation of CanAssist Breast in European early-stage breast cancer patient cohort
title_sort A retrospective validation of CanAssist Breast in European early-stage breast cancer patient cohort
dc.creator.none.fl_str_mv Gunda, Aparna
Basavaraj, Chetana
Pradhan, Prakash Chandra
Adinarayan, Manjula
Kolli, Ramu
Siraganahalli Eshwaraiah, Mallikarjuna
Ruiz Pace, Fiorella
Gómez Pardo, Patricia
Jiménez Flores, José Antonio
Saura Manich, Cristina
Peg, Vicente
author Gunda, Aparna
author_facet Gunda, Aparna
Basavaraj, Chetana
Pradhan, Prakash Chandra
Adinarayan, Manjula
Kolli, Ramu
Siraganahalli Eshwaraiah, Mallikarjuna
Ruiz Pace, Fiorella
Gómez Pardo, Patricia
Jiménez Flores, José Antonio
Saura Manich, Cristina
Peg, Vicente
author_role author
author2 Basavaraj, Chetana
Pradhan, Prakash Chandra
Adinarayan, Manjula
Kolli, Ramu
Siraganahalli Eshwaraiah, Mallikarjuna
Ruiz Pace, Fiorella
Gómez Pardo, Patricia
Jiménez Flores, José Antonio
Saura Manich, Cristina
Peg, Vicente
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Gunda A, Basavaraj C, Serkad V CP, Adinarayan M, Kolli R, Siraganahalli Eshwaraiah M] OncoStem Diagnostics, Bengaluru, Karnataka, India. [Saura C, Ruiz F, Gomez P, Peg V, Jimenez J] Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Mama - Càncer - Prognosi
Diagnòstic immunohistoquímic
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::/diagnosis
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::/diagnóstico
topic Mama - Càncer - Prognosi
Diagnòstic immunohistoquímic
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::/diagnosis
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::/diagnóstico
description Hormone-receptor positive; Chemotherapy; Early-stage breast cancer
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7897
url https://hdl.handle.net/11351/7897
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The Breast;63
https://doi.org/10.1016/j.breast.2022.02.010
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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