Extracellular matrix protein anosmin‑1 overexpression alters dopaminergic phenotype in the CNS and the PNS with no pathogenic consequences in a MPTP model of Parkinson’s disease

The development and survival of dopaminergic neurons are influenced by the fibroblast growth factor (FGF) pathway. Anosmin-1 (A1) is an extracellular matrix protein that acts as a major regulator of this signaling pathway, controlling FGF diffusion, and receptor interaction and shuttling. In particu...

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Autores: Villadiego Luque, Francisco Javier, García Swinburn, Roberto, García González, Diego, Lebrón-Galán, Rafael, Murcia-Belmonte, Verónica, García Roldán, Ernesto, Suárez-Luna, Nela, Nombela, Cristina, Marchena, Miguel Ángel, Castro, Fernando de, Toledo Aral, Juan José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/167121
Acceso en línea:https://hdl.handle.net/11441/167121
https://doi.org/10.1007/s00429-023-02631-0
Access Level:acceso abierto
Palabra clave:Anosmin-1 · FGF
Dopaminergic neurons
Nigrostriatal pathway
Striosome–matrix compartments
Parkinsonism
Carotid body ·
Adrenal medulla
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spelling Extracellular matrix protein anosmin‑1 overexpression alters dopaminergic phenotype in the CNS and the PNS with no pathogenic consequences in a MPTP model of Parkinson’s diseaseVilladiego Luque, Francisco JavierGarcía Swinburn, RobertoGarcía González, DiegoLebrón-Galán, RafaelMurcia-Belmonte, VerónicaGarcía Roldán, ErnestoSuárez-Luna, NelaNombela, CristinaMarchena, Miguel ÁngelCastro, Fernando deToledo Aral, Juan JoséAnosmin-1 · FGFDopaminergic neuronsNigrostriatal pathwayStriosome–matrix compartmentsParkinsonismCarotid body ·Adrenal medullaThe development and survival of dopaminergic neurons are influenced by the fibroblast growth factor (FGF) pathway. Anosmin-1 (A1) is an extracellular matrix protein that acts as a major regulator of this signaling pathway, controlling FGF diffusion, and receptor interaction and shuttling. In particular, previous work showed that A1 overexpression results in more dopaminergic neurons in the olfactory bulb. Prompted by those intriguing results, in this study, we investigated the effects of A1 overexpression on different populations of catecholaminergic neurons in the central (CNS) and the peripheral nerv ous systems (PNS). We found that A1 overexpression increases the number of dopaminergic substantia nigra pars compacta (SNpc) neurons and alters the striosome/matrix organization of the striatum. Interestingly, these numerical and morphological changes in the nigrostriatal pathway of A1-mice did not confer an altered susceptibility to experimental MPTP-parkinsonism with respect to wild-type controls. Moreover, the study of the effects of A1 overexpression was extended to different dopa minergic tissues associated with the PNS, detecting a significant reduction in the number of dopaminergic chemosensitive carotid body glomus cells in A1-mice. Overall, our work shows that A1 regulates the development and survival of dopamin ergic neurons in different nuclei of the mammalian nervous system.SpringerFisiología Médica y BiofísicaInstituto de Biomedicina de Sevilla (IBIS)CTS517: Fisiología molecularGobierno de EspañaInstituto de Salud Carlos IIIJunta de Andalucía2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/167121https://doi.org/10.1007/s00429-023-02631-0reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésBrain structure & function, 228 (3-4), 907-920.PID2019-105995RB-I00PID2019-109858RB-I00PI12/02574PI22/00156CTS2739 (J.J.T.-A.)https://link.springer.com/article/10.1007/s00429-023-02631-0info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1671212026-06-17T12:51:07Z
dc.title.none.fl_str_mv Extracellular matrix protein anosmin‑1 overexpression alters dopaminergic phenotype in the CNS and the PNS with no pathogenic consequences in a MPTP model of Parkinson’s disease
title Extracellular matrix protein anosmin‑1 overexpression alters dopaminergic phenotype in the CNS and the PNS with no pathogenic consequences in a MPTP model of Parkinson’s disease
spellingShingle Extracellular matrix protein anosmin‑1 overexpression alters dopaminergic phenotype in the CNS and the PNS with no pathogenic consequences in a MPTP model of Parkinson’s disease
Villadiego Luque, Francisco Javier
Anosmin-1 · FGF
Dopaminergic neurons
Nigrostriatal pathway
Striosome–matrix compartments
Parkinsonism
Carotid body ·
Adrenal medulla
title_short Extracellular matrix protein anosmin‑1 overexpression alters dopaminergic phenotype in the CNS and the PNS with no pathogenic consequences in a MPTP model of Parkinson’s disease
title_full Extracellular matrix protein anosmin‑1 overexpression alters dopaminergic phenotype in the CNS and the PNS with no pathogenic consequences in a MPTP model of Parkinson’s disease
title_fullStr Extracellular matrix protein anosmin‑1 overexpression alters dopaminergic phenotype in the CNS and the PNS with no pathogenic consequences in a MPTP model of Parkinson’s disease
title_full_unstemmed Extracellular matrix protein anosmin‑1 overexpression alters dopaminergic phenotype in the CNS and the PNS with no pathogenic consequences in a MPTP model of Parkinson’s disease
title_sort Extracellular matrix protein anosmin‑1 overexpression alters dopaminergic phenotype in the CNS and the PNS with no pathogenic consequences in a MPTP model of Parkinson’s disease
dc.creator.none.fl_str_mv Villadiego Luque, Francisco Javier
García Swinburn, Roberto
García González, Diego
Lebrón-Galán, Rafael
Murcia-Belmonte, Verónica
García Roldán, Ernesto
Suárez-Luna, Nela
Nombela, Cristina
Marchena, Miguel Ángel
Castro, Fernando de
Toledo Aral, Juan José
author Villadiego Luque, Francisco Javier
author_facet Villadiego Luque, Francisco Javier
García Swinburn, Roberto
García González, Diego
Lebrón-Galán, Rafael
Murcia-Belmonte, Verónica
García Roldán, Ernesto
Suárez-Luna, Nela
Nombela, Cristina
Marchena, Miguel Ángel
Castro, Fernando de
Toledo Aral, Juan José
author_role author
author2 García Swinburn, Roberto
García González, Diego
Lebrón-Galán, Rafael
Murcia-Belmonte, Verónica
García Roldán, Ernesto
Suárez-Luna, Nela
Nombela, Cristina
Marchena, Miguel Ángel
Castro, Fernando de
Toledo Aral, Juan José
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fisiología Médica y Biofísica
Instituto de Biomedicina de Sevilla (IBIS)
CTS517: Fisiología molecular
Gobierno de España
Instituto de Salud Carlos III
Junta de Andalucía
dc.subject.none.fl_str_mv Anosmin-1 · FGF
Dopaminergic neurons
Nigrostriatal pathway
Striosome–matrix compartments
Parkinsonism
Carotid body ·
Adrenal medulla
topic Anosmin-1 · FGF
Dopaminergic neurons
Nigrostriatal pathway
Striosome–matrix compartments
Parkinsonism
Carotid body ·
Adrenal medulla
description The development and survival of dopaminergic neurons are influenced by the fibroblast growth factor (FGF) pathway. Anosmin-1 (A1) is an extracellular matrix protein that acts as a major regulator of this signaling pathway, controlling FGF diffusion, and receptor interaction and shuttling. In particular, previous work showed that A1 overexpression results in more dopaminergic neurons in the olfactory bulb. Prompted by those intriguing results, in this study, we investigated the effects of A1 overexpression on different populations of catecholaminergic neurons in the central (CNS) and the peripheral nerv ous systems (PNS). We found that A1 overexpression increases the number of dopaminergic substantia nigra pars compacta (SNpc) neurons and alters the striosome/matrix organization of the striatum. Interestingly, these numerical and morphological changes in the nigrostriatal pathway of A1-mice did not confer an altered susceptibility to experimental MPTP-parkinsonism with respect to wild-type controls. Moreover, the study of the effects of A1 overexpression was extended to different dopa minergic tissues associated with the PNS, detecting a significant reduction in the number of dopaminergic chemosensitive carotid body glomus cells in A1-mice. Overall, our work shows that A1 regulates the development and survival of dopamin ergic neurons in different nuclei of the mammalian nervous system.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/167121
https://doi.org/10.1007/s00429-023-02631-0
url https://hdl.handle.net/11441/167121
https://doi.org/10.1007/s00429-023-02631-0
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Brain structure & function, 228 (3-4), 907-920.
PID2019-105995RB-I00
PID2019-109858RB-I00
PI12/02574
PI22/00156
CTS2739 (J.J.T.-A.)
https://link.springer.com/article/10.1007/s00429-023-02631-0
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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