A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood.

Little is known about the pathophysiological mechanisms of relapse in first-episode schizophrenia, which limits the study of potential biomarkers. To explore relapse mechanisms and identify potential biomarkers for relapse prediction, we analyzed gene expression in peripheral blood in a cohort of fi...

Descripción completa

Detalles Bibliográficos
Autores: Gassó Astorga, Patricia, Rodríguez Ferret, Natalia, Martínez Pinteño, Albert, Mezquida Mateos, Gisela, Ribeiro, M., González Peñas, Javier, Zorrilla, Iñaki, Martínez Sadurní, L., Rodriguez Jimenez, Roberto, Corripio, Iluminada, Sarró, Salvador, Ibáñez Cuadrado, Ángela, Usall i Rodié, Judith, Lobo, A., Morén Núñez, Constanza, Cuesta, Manuel J., Parellada, Mara, González-Pinto, Ana, Berrocoso, Esther, Bernardo Arroyo, Miquel, Mas Herrero, Sergi, 2EPs Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/184465
Acceso en línea:https://hdl.handle.net/2445/184465
Access Level:acceso abierto
Palabra clave:Esquizofrènia
Psiquiatria
Schizophrenia
Psychiatry
id ES_d400bbf72017dd09e0750375d5c9f243
oai_identifier_str oai:diposit.ub.edu:2445/184465
network_acronym_str ES
network_name_str España
repository_id_str
spelling A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood.Gassó Astorga, PatriciaRodríguez Ferret, NataliaMartínez Pinteño, AlbertMezquida Mateos, GiselaRibeiro, M.González Peñas, JavierZorrilla, IñakiMartínez Sadurní, L.Rodriguez Jimenez, RobertoCorripio, IluminadaSarró, SalvadorIbáñez Cuadrado, ÁngelaUsall i Rodié, JudithLobo, A.Morén Núñez, ConstanzaCuesta, Manuel J.Parellada, MaraGonzález-Pinto, AnaBerrocoso, EstherBernardo Arroyo, MiquelMas Herrero, Sergi2EPs GroupEsquizofrèniaPsiquiatriaSchizophreniaPsychiatryLittle is known about the pathophysiological mechanisms of relapse in first-episode schizophrenia, which limits the study of potential biomarkers. To explore relapse mechanisms and identify potential biomarkers for relapse prediction, we analyzed gene expression in peripheral blood in a cohort of first-episode schizophrenia patients with less than 5 years of evolution who had been evaluated over a 3-year follow-up period. A total of 91 participants of the 2EPs project formed the sample for baseline gene expression analysis. Of these, 67 provided biological samples at follow-up (36 after 3 years and 31 at relapse). Gene expression was assessed using the Clariom S Human Array. Weighted gene co-expression network analysis was applied to identify modules of co-expressed genes and to analyze their preservation after 3 years of follow-up or at relapse. Among the 25 modules identified, one module was semi-conserved at relapse (DarkTurquoise) and was enriched with risk genes for schizophrenia, showing a dysregulation of the TCF4 gene network in the module. Two modules were semi-conserved both at relapse and after 3 years of follow-up (DarkRed and DarkGrey) and were found to be biologically associated with protein modification and protein location processes. Higher expression of DarkRed genes was associated with higher risk of suffering a relapse and early appearance of relapse (p = 0.045). Our findings suggest that a dysregulation of the TCF4 network could be an important step in the biological process that leads to relapse and suggest that genes related to the ubiquitin proteosome system could be potential biomarkers of relapse.Nature Publishing Group2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/184465Articles publicats en revistes (Fonaments Clínics)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41398-021-01645-8Translational Psychiatry, 2021, vol. 11, num. 1, p. 539https://doi.org/10.1038/s41398-021-01645-8cc-by-nc-nd (c) Gassó Astorga, Patricia et al., 2021https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1844652026-05-27T06:46:51Z
dc.title.none.fl_str_mv A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood.
title A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood.
spellingShingle A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood.
Gassó Astorga, Patricia
Esquizofrènia
Psiquiatria
Schizophrenia
Psychiatry
title_short A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood.
title_full A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood.
title_fullStr A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood.
title_full_unstemmed A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood.
title_sort A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood.
dc.creator.none.fl_str_mv Gassó Astorga, Patricia
Rodríguez Ferret, Natalia
Martínez Pinteño, Albert
Mezquida Mateos, Gisela
Ribeiro, M.
González Peñas, Javier
Zorrilla, Iñaki
Martínez Sadurní, L.
Rodriguez Jimenez, Roberto
Corripio, Iluminada
Sarró, Salvador
Ibáñez Cuadrado, Ángela
Usall i Rodié, Judith
Lobo, A.
Morén Núñez, Constanza
Cuesta, Manuel J.
Parellada, Mara
González-Pinto, Ana
Berrocoso, Esther
Bernardo Arroyo, Miquel
Mas Herrero, Sergi
2EPs Group
author Gassó Astorga, Patricia
author_facet Gassó Astorga, Patricia
Rodríguez Ferret, Natalia
Martínez Pinteño, Albert
Mezquida Mateos, Gisela
Ribeiro, M.
González Peñas, Javier
Zorrilla, Iñaki
Martínez Sadurní, L.
Rodriguez Jimenez, Roberto
Corripio, Iluminada
Sarró, Salvador
Ibáñez Cuadrado, Ángela
Usall i Rodié, Judith
Lobo, A.
Morén Núñez, Constanza
Cuesta, Manuel J.
Parellada, Mara
González-Pinto, Ana
Berrocoso, Esther
Bernardo Arroyo, Miquel
Mas Herrero, Sergi
2EPs Group
author_role author
author2 Rodríguez Ferret, Natalia
Martínez Pinteño, Albert
Mezquida Mateos, Gisela
Ribeiro, M.
González Peñas, Javier
Zorrilla, Iñaki
Martínez Sadurní, L.
Rodriguez Jimenez, Roberto
Corripio, Iluminada
Sarró, Salvador
Ibáñez Cuadrado, Ángela
Usall i Rodié, Judith
Lobo, A.
Morén Núñez, Constanza
Cuesta, Manuel J.
Parellada, Mara
González-Pinto, Ana
Berrocoso, Esther
Bernardo Arroyo, Miquel
Mas Herrero, Sergi
2EPs Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Esquizofrènia
Psiquiatria
Schizophrenia
Psychiatry
topic Esquizofrènia
Psiquiatria
Schizophrenia
Psychiatry
description Little is known about the pathophysiological mechanisms of relapse in first-episode schizophrenia, which limits the study of potential biomarkers. To explore relapse mechanisms and identify potential biomarkers for relapse prediction, we analyzed gene expression in peripheral blood in a cohort of first-episode schizophrenia patients with less than 5 years of evolution who had been evaluated over a 3-year follow-up period. A total of 91 participants of the 2EPs project formed the sample for baseline gene expression analysis. Of these, 67 provided biological samples at follow-up (36 after 3 years and 31 at relapse). Gene expression was assessed using the Clariom S Human Array. Weighted gene co-expression network analysis was applied to identify modules of co-expressed genes and to analyze their preservation after 3 years of follow-up or at relapse. Among the 25 modules identified, one module was semi-conserved at relapse (DarkTurquoise) and was enriched with risk genes for schizophrenia, showing a dysregulation of the TCF4 gene network in the module. Two modules were semi-conserved both at relapse and after 3 years of follow-up (DarkRed and DarkGrey) and were found to be biologically associated with protein modification and protein location processes. Higher expression of DarkRed genes was associated with higher risk of suffering a relapse and early appearance of relapse (p = 0.045). Our findings suggest that a dysregulation of the TCF4 network could be an important step in the biological process that leads to relapse and suggest that genes related to the ubiquitin proteosome system could be potential biomarkers of relapse.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/184465
url https://hdl.handle.net/2445/184465
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41398-021-01645-8
Translational Psychiatry, 2021, vol. 11, num. 1, p. 539
https://doi.org/10.1038/s41398-021-01645-8
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Gassó Astorga, Patricia et al., 2021
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Gassó Astorga, Patricia et al., 2021
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420508867461120
score 15.301603

Similares en LA Referencia