In Silico Modelling to Assess the Electrical and Thermal Disturbance Provoked by a Metal Intracoronary Stent during Epicardial Pulsed Electric Field Ablation

[EN] Background: Pulsed Electric Field (PEF) ablation has been recently proposed to ablate cardiac ganglionic plexi (GP) aimed to treat atrial fibrillation. The effect of metal intracoronary stents in the vicinity of the ablation electrode has not been yet assessed. Methods: A 2D numerical model was...

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Autores: González-Suárez, Ana|||0000-0002-1813-4176, Pérez, Juan J|||0000-0001-8486-8699, O Brien, Barry, Elahi, Adnan
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/196278
Acesso em linha:https://riunet.upv.es/handle/10251/196278
Access Level:acceso abierto
Palavra-chave:Biophysics
Computer modeling
Impedance
Radiofrequency catheter ablation
Cardiac arrhythmia
Computer modelling
Coronary artery
Epicardial ablation
Metal stent
Pulsed field ablation
TECNOLOGIA ELECTRONICA
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oai_identifier_str oai:riunet.upv.es:10251/196278
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv In Silico Modelling to Assess the Electrical and Thermal Disturbance Provoked by a Metal Intracoronary Stent during Epicardial Pulsed Electric Field Ablation
title In Silico Modelling to Assess the Electrical and Thermal Disturbance Provoked by a Metal Intracoronary Stent during Epicardial Pulsed Electric Field Ablation
spellingShingle In Silico Modelling to Assess the Electrical and Thermal Disturbance Provoked by a Metal Intracoronary Stent during Epicardial Pulsed Electric Field Ablation
González-Suárez, Ana|||0000-0002-1813-4176
Biophysics
Computer modeling
Impedance
Radiofrequency catheter ablation
Cardiac arrhythmia
Computer modelling
Coronary artery
Epicardial ablation
Metal stent
Pulsed field ablation
TECNOLOGIA ELECTRONICA
title_short In Silico Modelling to Assess the Electrical and Thermal Disturbance Provoked by a Metal Intracoronary Stent during Epicardial Pulsed Electric Field Ablation
title_full In Silico Modelling to Assess the Electrical and Thermal Disturbance Provoked by a Metal Intracoronary Stent during Epicardial Pulsed Electric Field Ablation
title_fullStr In Silico Modelling to Assess the Electrical and Thermal Disturbance Provoked by a Metal Intracoronary Stent during Epicardial Pulsed Electric Field Ablation
title_full_unstemmed In Silico Modelling to Assess the Electrical and Thermal Disturbance Provoked by a Metal Intracoronary Stent during Epicardial Pulsed Electric Field Ablation
title_sort In Silico Modelling to Assess the Electrical and Thermal Disturbance Provoked by a Metal Intracoronary Stent during Epicardial Pulsed Electric Field Ablation
dc.creator.none.fl_str_mv González-Suárez, Ana|||0000-0002-1813-4176
Pérez, Juan J|||0000-0001-8486-8699
O Brien, Barry
Elahi, Adnan
author González-Suárez, Ana|||0000-0002-1813-4176
author_facet González-Suárez, Ana|||0000-0002-1813-4176
Pérez, Juan J|||0000-0001-8486-8699
O Brien, Barry
Elahi, Adnan
author_role author
author2 Pérez, Juan J|||0000-0001-8486-8699
O Brien, Barry
Elahi, Adnan
author2_role author
author
author
dc.contributor.none.fl_str_mv Departamento de Ingeniería Electrónica
Escuela Técnica Superior de Ingeniería Industrial
Escuela Politécnica Superior de Gandia
Biosignals & Minimally Invasive Technologies-BioMIT
Government of Ireland
AGENCIA ESTATAL DE INVESTIGACION
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Biophysics
Computer modeling
Impedance
Radiofrequency catheter ablation
Cardiac arrhythmia
Computer modelling
Coronary artery
Epicardial ablation
Metal stent
Pulsed field ablation
TECNOLOGIA ELECTRONICA
topic Biophysics
Computer modeling
Impedance
Radiofrequency catheter ablation
Cardiac arrhythmia
Computer modelling
Coronary artery
Epicardial ablation
Metal stent
Pulsed field ablation
TECNOLOGIA ELECTRONICA
description [EN] Background: Pulsed Electric Field (PEF) ablation has been recently proposed to ablate cardiac ganglionic plexi (GP) aimed to treat atrial fibrillation. The effect of metal intracoronary stents in the vicinity of the ablation electrode has not been yet assessed. Methods: A 2D numerical model was developed accounting for the different tissues involved in PEF ablation with an irrigated ablation device. A coronary artery (with and without a metal intracoronary stent) was considered near the ablation source (0.25 and 1 mm separation). The 1000 V/cm threshold was used to estimate the PEF-zone¿. Results: The presence of the coronary artery (with or without stent) distorts the E-field distribution, creating hot spots (higher E-field values) in the front and rear of the artery, and cold spots (lower E-field values) on the sides of the artery. The value of the E-field inside the coronary artery is very low (~200 V/cm), and almost zero with a metal stent. Despite this distortion, thePEF-zone contour is almost identical with and without artery/stent, remaining almost completely confined within the fat layer in any case. The mentioned hot spots of E-field translate into a moderate temperature increase (<48 _C) in the area between the artery and electrode. These thermal side effects are similar for pulse intervals of 10 and 100 _s. Conclusions: The presence of a metal intracoronary stent near the ablation device during PEF ablation simply `amplifies¿ the E-field distortion already caused by the presence of the vessel. This distortion may involve moderate heating (<48 _C) in the tissue between the artery and ablation electrode without associate Background: Pulsed Electric Field (PEF) ablation has been recently proposed to ablate cardiac ganglionic plexi (GP) aimed to treat atrial fibrillation. The effect of metal intracoronary stents in the vicinity of the ablation electrode has not been yet assessed. Methods: A 2D numerical model was developed accounting for the different tissues involved in PEF ablation with an irrigated ablation device. A coronary artery (with and without a metal intracoronary stent) was considered near the ablation source (0.25 and 1 mm separation). The 1000 V/cm threshold was used to estimate the `PEF-zone¿. Results: The presence of the coronary artery (with or without stent) distorts the E-field distribution, creating hot spots (higher E-field values) in the front and rear of the artery, and cold spots (lower E-field values) on the sides of the artery. The value of the E-field inside the coronary artery is very low (~200 V/cm), and almost zero with a metal stent. Despite this distortion, the PEF-zone contour is almost identical with and without artery/stent, remaining almost completely confined within the fat layer in any case. The mentioned hot spots of E-field translate into a moderate temperature increase (<48 _C) in the area between the artery and electrode. These thermal side effects are similar for pulse intervals of 10 and 100 _s. Conclusions: The presence of a metal intracoronary stent near the ablation device during PEF ablation simply `amplifies¿ the E-field distortion already caused by the presence of the vessel. This distortion may involve moderate heating (<48 _C) in the tissue between the artery and ablation electrode without associated thermal damage. d thermal damage.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-12-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/196278
url https://riunet.upv.es/handle/10251/196278
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-094357-B-C21 MODELADO Y EXPERIMENTACION PARA TERAPIAS ABLATIVAS INNOVADORAS
Government of Ireland Government of Ireland DT20180123
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420507815739392
spelling In Silico Modelling to Assess the Electrical and Thermal Disturbance Provoked by a Metal Intracoronary Stent during Epicardial Pulsed Electric Field AblationGonzález-Suárez, Ana|||0000-0002-1813-4176Pérez, Juan J|||0000-0001-8486-8699O Brien, BarryElahi, AdnanBiophysicsComputer modelingImpedanceRadiofrequency catheter ablationCardiac arrhythmiaComputer modellingCoronary arteryEpicardial ablationMetal stentPulsed field ablationTECNOLOGIA ELECTRONICA[EN] Background: Pulsed Electric Field (PEF) ablation has been recently proposed to ablate cardiac ganglionic plexi (GP) aimed to treat atrial fibrillation. The effect of metal intracoronary stents in the vicinity of the ablation electrode has not been yet assessed. Methods: A 2D numerical model was developed accounting for the different tissues involved in PEF ablation with an irrigated ablation device. A coronary artery (with and without a metal intracoronary stent) was considered near the ablation source (0.25 and 1 mm separation). The 1000 V/cm threshold was used to estimate the PEF-zone¿. Results: The presence of the coronary artery (with or without stent) distorts the E-field distribution, creating hot spots (higher E-field values) in the front and rear of the artery, and cold spots (lower E-field values) on the sides of the artery. The value of the E-field inside the coronary artery is very low (~200 V/cm), and almost zero with a metal stent. Despite this distortion, thePEF-zone contour is almost identical with and without artery/stent, remaining almost completely confined within the fat layer in any case. The mentioned hot spots of E-field translate into a moderate temperature increase (<48 _C) in the area between the artery and electrode. These thermal side effects are similar for pulse intervals of 10 and 100 _s. Conclusions: The presence of a metal intracoronary stent near the ablation device during PEF ablation simply `amplifies¿ the E-field distortion already caused by the presence of the vessel. This distortion may involve moderate heating (<48 _C) in the tissue between the artery and ablation electrode without associate Background: Pulsed Electric Field (PEF) ablation has been recently proposed to ablate cardiac ganglionic plexi (GP) aimed to treat atrial fibrillation. The effect of metal intracoronary stents in the vicinity of the ablation electrode has not been yet assessed. Methods: A 2D numerical model was developed accounting for the different tissues involved in PEF ablation with an irrigated ablation device. A coronary artery (with and without a metal intracoronary stent) was considered near the ablation source (0.25 and 1 mm separation). The 1000 V/cm threshold was used to estimate the `PEF-zone¿. Results: The presence of the coronary artery (with or without stent) distorts the E-field distribution, creating hot spots (higher E-field values) in the front and rear of the artery, and cold spots (lower E-field values) on the sides of the artery. The value of the E-field inside the coronary artery is very low (~200 V/cm), and almost zero with a metal stent. Despite this distortion, the PEF-zone contour is almost identical with and without artery/stent, remaining almost completely confined within the fat layer in any case. The mentioned hot spots of E-field translate into a moderate temperature increase (<48 _C) in the area between the artery and electrode. These thermal side effects are similar for pulse intervals of 10 and 100 _s. Conclusions: The presence of a metal intracoronary stent near the ablation device during PEF ablation simply `amplifies¿ the E-field distortion already caused by the presence of the vessel. This distortion may involve moderate heating (<48 _C) in the tissue between the artery and ablation electrode without associated thermal damage. d thermal damage.This research was funded by Government of Ireland, Disruptive Technology Innovation Fund (DTIF), grant number DT20180123, and Spanish MCIN/AEI/10.13039/501100011033, grant RTI2018-094357-B-C21.MDPI AGDepartamento de Ingeniería ElectrónicaEscuela Técnica Superior de Ingeniería IndustrialEscuela Politécnica Superior de GandiaBiosignals & Minimally Invasive Technologies-BioMITGovernment of IrelandAGENCIA ESTATAL DE INVESTIGACIONRepositorio Institucional de la Universitat Politècnica de València Riunet20222022-12-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/196278reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-094357-B-C21 MODELADO Y EXPERIMENTACION PARA TERAPIAS ABLATIVAS INNOVADORASGovernment of Ireland Government of Ireland DT20180123open accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1962782026-06-13T07:49:27Z
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