Placental-site trophoblastic tumor with bone metastasis: A diagnostic and therapeutic challenge

Placental-site trophoblastic tumor (PSTT) is a rare pathological entity included in the spectrum of gestational trophoblastic neoplasia (GTN). It is a neoplasia with metastatic potential that, once metastasized, has poor prognosis because the tumor tends to be less sensitive to chemotherapy. We pres...

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Detalles Bibliográficos
Autores: Ramírez Espinoza, Alfredo, Vela, Irene, Server, Laura, Rodríguez Celdrán, Juan M., Chuliá, María T., Quereda, Francisco
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Miguel Hernández de Elche
Repositorio:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/30951
Acceso en línea:https://hdl.handle.net/11000/30951
Access Level:acceso abierto
Palabra clave:PSTT
Placental-site trophoblastic tumor
Mole hydatidiform
Gestational trophoblastic neoplasia
Bone metastasis
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spelling Placental-site trophoblastic tumor with bone metastasis: A diagnostic and therapeutic challengeRamírez Espinoza, AlfredoVela, IreneServer, LauraRodríguez Celdrán, Juan M.Chuliá, María T.Quereda, FranciscoPSTTPlacental-site trophoblastic tumorMole hydatidiformGestational trophoblastic neoplasiaBone metastasisPlacental-site trophoblastic tumor (PSTT) is a rare pathological entity included in the spectrum of gestational trophoblastic neoplasia (GTN). It is a neoplasia with metastatic potential that, once metastasized, has poor prognosis because the tumor tends to be less sensitive to chemotherapy. We present a rare case of gestational trophoblastic neoplasia, in which hysterectomy for persistent gestational trophoblastic disease after hydatidiform mole, revealed a primary PSTT in the uterus. Subsequently, a slight persistent elevation of the beta fraction of human chorionic gonadotropin hormone (B-hCG) during follow-up revealed the presence of bone metastases. This location is not usual from this tumor, being even more rare the case of PSTT with isolated bone metastases. Metastasic foci were only identified with PET-CT since the usual diagnostic resources were not able to do it. Finally, it is also remarkable in our case that the treatment required the confluence of chemotherapy together with immunotherapy to achieve a favorable response.Elsevier [Commercial Publisher]Departamentos de la UMH::Salud Pública, Historia de la Ciencia y Ginecología202420242023info:eu-repo/semantics/articleapplication/pdf6application/pdfhttps://hdl.handle.net/11000/30951reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheEspañolhttps://doi.org/10.1016/j.gore.2023.101304info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/309512026-05-27T13:36:21Z
dc.title.none.fl_str_mv Placental-site trophoblastic tumor with bone metastasis: A diagnostic and therapeutic challenge
title Placental-site trophoblastic tumor with bone metastasis: A diagnostic and therapeutic challenge
spellingShingle Placental-site trophoblastic tumor with bone metastasis: A diagnostic and therapeutic challenge
Ramírez Espinoza, Alfredo
PSTT
Placental-site trophoblastic tumor
Mole hydatidiform
Gestational trophoblastic neoplasia
Bone metastasis
title_short Placental-site trophoblastic tumor with bone metastasis: A diagnostic and therapeutic challenge
title_full Placental-site trophoblastic tumor with bone metastasis: A diagnostic and therapeutic challenge
title_fullStr Placental-site trophoblastic tumor with bone metastasis: A diagnostic and therapeutic challenge
title_full_unstemmed Placental-site trophoblastic tumor with bone metastasis: A diagnostic and therapeutic challenge
title_sort Placental-site trophoblastic tumor with bone metastasis: A diagnostic and therapeutic challenge
dc.creator.none.fl_str_mv Ramírez Espinoza, Alfredo
Vela, Irene
Server, Laura
Rodríguez Celdrán, Juan M.
Chuliá, María T.
Quereda, Francisco
author Ramírez Espinoza, Alfredo
author_facet Ramírez Espinoza, Alfredo
Vela, Irene
Server, Laura
Rodríguez Celdrán, Juan M.
Chuliá, María T.
Quereda, Francisco
author_role author
author2 Vela, Irene
Server, Laura
Rodríguez Celdrán, Juan M.
Chuliá, María T.
Quereda, Francisco
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Departamentos de la UMH::Salud Pública, Historia de la Ciencia y Ginecología
dc.subject.none.fl_str_mv PSTT
Placental-site trophoblastic tumor
Mole hydatidiform
Gestational trophoblastic neoplasia
Bone metastasis
topic PSTT
Placental-site trophoblastic tumor
Mole hydatidiform
Gestational trophoblastic neoplasia
Bone metastasis
description Placental-site trophoblastic tumor (PSTT) is a rare pathological entity included in the spectrum of gestational trophoblastic neoplasia (GTN). It is a neoplasia with metastatic potential that, once metastasized, has poor prognosis because the tumor tends to be less sensitive to chemotherapy. We present a rare case of gestational trophoblastic neoplasia, in which hysterectomy for persistent gestational trophoblastic disease after hydatidiform mole, revealed a primary PSTT in the uterus. Subsequently, a slight persistent elevation of the beta fraction of human chorionic gonadotropin hormone (B-hCG) during follow-up revealed the presence of bone metastases. This location is not usual from this tumor, being even more rare the case of PSTT with isolated bone metastases. Metastasic foci were only identified with PET-CT since the usual diagnostic resources were not able to do it. Finally, it is also remarkable in our case that the treatment required the confluence of chemotherapy together with immunotherapy to achieve a favorable response.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11000/30951
url https://hdl.handle.net/11000/30951
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.gore.2023.101304
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
6
application/pdf
dc.publisher.none.fl_str_mv Elsevier [Commercial Publisher]
publisher.none.fl_str_mv Elsevier [Commercial Publisher]
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universidad Miguel Hernández de Elche
instname_str Universidad Miguel Hernández de Elche
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.198674

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