Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease

Introduction: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpa...

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Autores: Rodríguez-Fernández, Blanca, Sánchez-Benavides, Gonzalo, Genius, Patricia, Minguillón, Carolina, Fauria, Karine, De Vivo, Immaculata, Navarro, Arcadi, Molinuevo, Jose Luis, Gispert, Juan Domingo, Sala-Vila, Aleix, Vilor Tejedor, Natalia, Crous Bou, Marta
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/215735
Acceso en línea:https://hdl.handle.net/2445/215735
Access Level:acceso abierto
Palabra clave:Malaltia d'Alzheimer
Telòmer
Alzheimer's disease
Telomere
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spelling Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s diseaseRodríguez-Fernández, BlancaSánchez-Benavides, GonzaloGenius, PatriciaMinguillón, CarolinaFauria, KarineDe Vivo, ImmaculataNavarro, ArcadiMolinuevo, Jose LuisGispert, Juan DomingoSala-Vila, AleixVilor Tejedor, NataliaCrous Bou, MartaMalaltia d'AlzheimerTelòmerAlzheimer's diseaseTelomereIntroduction: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD. Methods: A total of 1520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR. LTL was residualized against age and sex, and associations with cognitive performance were assessed in short and long groups based on residualized LTL (rLTL). Interactions with sex and genetic risk of AD were tested. Results: Non-linear associations were found between LTL and episodic memory (EM). Better EM was associated with longer rLTL among women in the short rLTL group. Discussion: Results suggest a potential role of telomeres in the cognitive aging process with sex-specific patterns.Elsevier BV2024202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/215735Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.neurobiolaging.2024.05.015Neurobiology of Aging, 2024, vol. 141, p. 140-150https://doi.org/10.1016/j.neurobiolaging.2024.05.015cc by-nc-nd (c) Rodríguez-Fernánez, Blanca et al., 2024http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2157352026-05-29T05:05:01Z
dc.title.none.fl_str_mv Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease
title Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease
spellingShingle Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease
Rodríguez-Fernández, Blanca
Malaltia d'Alzheimer
Telòmer
Alzheimer's disease
Telomere
title_short Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease
title_full Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease
title_fullStr Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease
title_full_unstemmed Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease
title_sort Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease
dc.creator.none.fl_str_mv Rodríguez-Fernández, Blanca
Sánchez-Benavides, Gonzalo
Genius, Patricia
Minguillón, Carolina
Fauria, Karine
De Vivo, Immaculata
Navarro, Arcadi
Molinuevo, Jose Luis
Gispert, Juan Domingo
Sala-Vila, Aleix
Vilor Tejedor, Natalia
Crous Bou, Marta
author Rodríguez-Fernández, Blanca
author_facet Rodríguez-Fernández, Blanca
Sánchez-Benavides, Gonzalo
Genius, Patricia
Minguillón, Carolina
Fauria, Karine
De Vivo, Immaculata
Navarro, Arcadi
Molinuevo, Jose Luis
Gispert, Juan Domingo
Sala-Vila, Aleix
Vilor Tejedor, Natalia
Crous Bou, Marta
author_role author
author2 Sánchez-Benavides, Gonzalo
Genius, Patricia
Minguillón, Carolina
Fauria, Karine
De Vivo, Immaculata
Navarro, Arcadi
Molinuevo, Jose Luis
Gispert, Juan Domingo
Sala-Vila, Aleix
Vilor Tejedor, Natalia
Crous Bou, Marta
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia d'Alzheimer
Telòmer
Alzheimer's disease
Telomere
topic Malaltia d'Alzheimer
Telòmer
Alzheimer's disease
Telomere
description Introduction: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD. Methods: A total of 1520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR. LTL was residualized against age and sex, and associations with cognitive performance were assessed in short and long groups based on residualized LTL (rLTL). Interactions with sex and genetic risk of AD were tested. Results: Non-linear associations were found between LTL and episodic memory (EM). Better EM was associated with longer rLTL among women in the short rLTL group. Discussion: Results suggest a potential role of telomeres in the cognitive aging process with sex-specific patterns.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/215735
url https://hdl.handle.net/2445/215735
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.neurobiolaging.2024.05.015
Neurobiology of Aging, 2024, vol. 141, p. 140-150
https://doi.org/10.1016/j.neurobiolaging.2024.05.015
dc.rights.none.fl_str_mv cc by-nc-nd (c) Rodríguez-Fernánez, Blanca et al., 2024
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Rodríguez-Fernánez, Blanca et al., 2024
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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