Overlooked and valuable facts to know in the NRF2/KEAP1 field
NRF2 (nuclear factor erythroid 2-related factor 2) is a critical regulator of the cellular stress response. It is a transcription factor that controls the expression of hundreds of genes. We will soon celebrate the thirtieth anniversary of its discovery [1]. Over the years, NRF2 and its repressor KE...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/289786 |
| Acceso en línea: | http://hdl.handle.net/10261/289786 |
| Access Level: | acceso abierto |
| Palabra clave: | NRF2 KEAP1 Molecular weight Oxidative stress Knockout mice Antibodies |
| Sumario: | NRF2 (nuclear factor erythroid 2-related factor 2) is a critical regulator of the cellular stress response. It is a transcription factor that controls the expression of hundreds of genes. We will soon celebrate the thirtieth anniversary of its discovery [1]. Over the years, NRF2 and its repressor KEAP1 have become the subject of intensive research, ranging from the detailed molecular mechanisms of their activity to clinical perspectives and generating over a dozen thousand publications. This review intends to draw the attention of researchers to essential issues in the NRF2/KEAP1 field, highlighting the overlooked facts and clarifying potential misconceptions. |
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