The autotaxin-lysophosphatidic acid pathway in pathogenesis of rheumatoid arthritis
[EN] Lysophosphatidicacid (LPA )is a phospholipid that i smainly produced by the hydrolysis of lysopho- sphatidylcholine (LPC) by lysophospholipase D, which is also called autotaxin (ATX).LPA interacts with specific G-protein coupled receptors and is involved in the regulation of cellular survival,...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Servizo Galego de Saúde (SERGAS) |
| Repositorio: | RUNA. Repositorio da Consellería de Sanidade e Sergas |
| OAI Identifier: | oai:runa.sergas.gal:20.500.11940/17741 |
| Acceso en línea: | https://pubmed.ncbi.nlm.nih.gov/26297977/ http://hdl.handle.net/20.500.11940/17741 |
| Access Level: | acceso abierto |
| Palabra clave: | Apoptosis Synoviocytes Lysophospholipase Synovial Fluid Arthritis, Experimental Arthritis Synovial Membrane Signal Transduction Phosphoric Diester Hydrolases Conflict of Interest Arthritis, Rheumatoid RNA, Messenger Lysophospholipids apoptosis líquido sinovial membrana sinovial diéster fosfórico hidrolasas lisofosfolipasa lisofosfolípidos artritis experimental transducción de señales artritis artritis reumatoide ARN mensajero IDIS CHUS |
| Sumario: | [EN] Lysophosphatidicacid (LPA )is a phospholipid that i smainly produced by the hydrolysis of lysopho- sphatidylcholine (LPC) by lysophospholipase D, which is also called autotaxin (ATX).LPA interacts with specific G-protein coupled receptors and is involved in the regulation of cellular survival, proliferation,differentiation and motility . LPA also has roles in several pathological disorders, such as cancer and pulmonary, dermal and renal fibrosis. The involvement of the ATX–LPA pathway has recently been demonstrated in inflammatory responses and apoptosis of fibroblast like synoviocytes (FLS) from patients with rheumatoid arthritis and during the development of experimental arthritis.This review summarises the current literature of the ATX–LPA pathway in rheumatoid arthritis. |
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