A Low Number of Baselines ?d T Cells Increases the Risk of SARS-CoV-2 Post-Vaccination Infection
Background: The COVID-19 pandemic is the biggest global health problem in the last hundred years. The efficacy of the vaccine to protect against severe disease is estimated to be 70-95% according to the studies carried out, although there are aspects of the immune response to the vaccine that remain...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repositorio: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:fisabio.fundanetsuite.com:p17079 |
| Acceso en línea: | https://fisabio.portalinvestigacion.com/publicaciones/17079 |
| Access Level: | acceso abierto |
| Palabra clave: | SARS-CoV-2 vaccine antibodies alpha beta T cells gamma delta T cells |
| Sumario: | Background: The COVID-19 pandemic is the biggest global health problem in the last hundred years. The efficacy of the vaccine to protect against severe disease is estimated to be 70-95% according to the studies carried out, although there are aspects of the immune response to the vaccine that remain unclear. Methods: Humoral and cellular immunity after the administration of three doses of the Pfizer-BioNTech and Oxford AstraZeneca vaccines against SARS-CoV-2 over one year and the appearance of post-vaccination COVID-19 were studied. SARS-CoV-2 IgG and IgA antibodies, alpha beta and gamma delta T-cell subsets, and their differentiation stages and apoptosis were analyzed. Results: Anti-SARS-CoV-2 IgG and IgA antibodies showed a progressive increase throughout the duration of the study. This increase was the greatest after the third dose. The highest levels were observed in subjects who had anti-SARS-CoV-2 antibodies prior to vaccination. There was an increase in CD4+ alpha beta, CD8+ gamma delta and TEM CD8+ gamma delta T cells, and a decrease in apoptosis in CD4+ CD8+ and CD56+ alpha beta and gamma delta T cells. Post-vaccination SARS-CoV-2 infection was greater than 60%. The symptoms of COVID-19 were very mild and were related to a gamma delta T cell deficit, specifically CD8+ TEMRA and CD56+ gamma delta TEM, as well as lower pre-vaccine apoptosis levels. Conclusions: The results unveil the important role of gamma delta T cells in SARS-CoV-2-vaccine-mediated protection from the disease. |
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