Dissecting the functions of cancer-associated fibroblasts to therapeutically target head and neck cancer microenvironment

Head and neck cancers (HNC) are a diverse group of aggressive malignancies with high morbidity and mortality, leading to almost half-million deaths annually worldwide. A better understanding of the molecular processes governing tumor formation and progression is crucial to improve current diagnostic...

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Authors: Prieto-Fernández, Llara, Montoro-Jiménez, Irene, Luxan-Delgado, Beatriz de, Otero-Rosales, María, Rodrigo, Juan P., Calvo González, Fernando|||0000-0001-8858-1185, García-Pedrero, Juana M., Álvarez-Teijeiro, Saúl
Format: article
Publication Date:2023
Country:España
Institution:Universidad de Cantabria (UC)
Repository:UCrea Repositorio Abierto de la Universidad de Cantabria
Language:English
OAI Identifier:oai:repositorio.unican.es:10902/30085
Online Access:https://hdl.handle.net/10902/30085
Access Level:Open access
Keyword:Head and neck cancer
Tumor microenvironment
Cancer hallmarks
Fibroblast
CAFs
CAFs-based therapies
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spelling Dissecting the functions of cancer-associated fibroblasts to therapeutically target head and neck cancer microenvironmentPrieto-Fernández, LlaraMontoro-Jiménez, IreneLuxan-Delgado, Beatriz deOtero-Rosales, MaríaRodrigo, Juan P.Calvo González, Fernando|||0000-0001-8858-1185García-Pedrero, Juana M.Álvarez-Teijeiro, SaúlHead and neck cancerTumor microenvironmentCancer hallmarksFibroblastCAFsCAFs-based therapiesHead and neck cancers (HNC) are a diverse group of aggressive malignancies with high morbidity and mortality, leading to almost half-million deaths annually worldwide. A better understanding of the molecular processes governing tumor formation and progression is crucial to improve current diagnostic and prognostic tools as well as to develop more personalized treatment strategies. Tumors are highly complex and heterogeneous structures in which growth and dissemination is not only governed by the cancer cells intrinsic mechanisms, but also by the surrounding tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) emerge as predominant TME components and key players in the generation of permissive conditions that ultimately impact in tumor progression and metastatic dissemination. Although CAFs were initially considered a consequence of tumor development, it is now well established that they actively contribute to numerous cancer hallmarks i.e., tumor cell growth, migration and invasion, cancer cell stemness, angiogenesis, metabolic reprograming, inflammation, and immune system modulation. In this scenario, therapeutic strategies targeting CAF functions could potentially have a major impact in cancer therapeutics, providing avenues for new treatment options or for improving efficacy in established approaches. This review is focused on thoroughly dissecting existing evidences supporting the contribution of CAFs in HNC biology with an emphasis on current knowledge of the key molecules and pathways involved in CAF-tumor crosstalk, and their potential as novel biomarkers and/or therapeutic targets to effectively interfere the tumor-stroma crosstalk for HNC patients benefit. involved in CAF-tumor crosstalk, and their potential as novel biomarkers and/or therapeutic targets to effec- tively interfere the tumor-stroma crosstalk for HNC patients benefitFunding. This study was supported by the Instituto de Salud Carlos III (ISCIII) through the project grants PI19/00560, PI22/00167 and CIBERONC (CB16/12/00390) and co-funded by the European Union, FINBA-ISPA (2021–047-INTRAMURAL NOV-ALTES; sponsored by Janssen), the Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Fundación Bancaria Cajastur-IUOPA, Ayudas para Grupos de Investigación de Organismos del Principado de Asturias 2021–2023 (IDI/ 2021/000079) and the FEDER Funding Program from the European Union. SAT is recipient of a Sara Borrell postdoctoral fellowship from ISCIII (CD20/00006). LPF is recipient of an FPU-PhD fellowship from the Spanish Ministry of Education (FPU20/01588), and IMJ recipient of a Severo Ochoa predoctoral fellowship from the Principado de Asturias (BP20–152)Editions Scientifiques ElsevierUniversidad de Cantabria20232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/30085Biomedicine and Pharmacotherapy, 2023, 161, 114502reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/300852026-06-02T12:39:31Z
dc.title.none.fl_str_mv Dissecting the functions of cancer-associated fibroblasts to therapeutically target head and neck cancer microenvironment
title Dissecting the functions of cancer-associated fibroblasts to therapeutically target head and neck cancer microenvironment
spellingShingle Dissecting the functions of cancer-associated fibroblasts to therapeutically target head and neck cancer microenvironment
Prieto-Fernández, Llara
Head and neck cancer
Tumor microenvironment
Cancer hallmarks
Fibroblast
CAFs
CAFs-based therapies
title_short Dissecting the functions of cancer-associated fibroblasts to therapeutically target head and neck cancer microenvironment
title_full Dissecting the functions of cancer-associated fibroblasts to therapeutically target head and neck cancer microenvironment
title_fullStr Dissecting the functions of cancer-associated fibroblasts to therapeutically target head and neck cancer microenvironment
title_full_unstemmed Dissecting the functions of cancer-associated fibroblasts to therapeutically target head and neck cancer microenvironment
title_sort Dissecting the functions of cancer-associated fibroblasts to therapeutically target head and neck cancer microenvironment
dc.creator.none.fl_str_mv Prieto-Fernández, Llara
Montoro-Jiménez, Irene
Luxan-Delgado, Beatriz de
Otero-Rosales, María
Rodrigo, Juan P.
Calvo González, Fernando|||0000-0001-8858-1185
García-Pedrero, Juana M.
Álvarez-Teijeiro, Saúl
author Prieto-Fernández, Llara
author_facet Prieto-Fernández, Llara
Montoro-Jiménez, Irene
Luxan-Delgado, Beatriz de
Otero-Rosales, María
Rodrigo, Juan P.
Calvo González, Fernando|||0000-0001-8858-1185
García-Pedrero, Juana M.
Álvarez-Teijeiro, Saúl
author_role author
author2 Montoro-Jiménez, Irene
Luxan-Delgado, Beatriz de
Otero-Rosales, María
Rodrigo, Juan P.
Calvo González, Fernando|||0000-0001-8858-1185
García-Pedrero, Juana M.
Álvarez-Teijeiro, Saúl
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Head and neck cancer
Tumor microenvironment
Cancer hallmarks
Fibroblast
CAFs
CAFs-based therapies
topic Head and neck cancer
Tumor microenvironment
Cancer hallmarks
Fibroblast
CAFs
CAFs-based therapies
description Head and neck cancers (HNC) are a diverse group of aggressive malignancies with high morbidity and mortality, leading to almost half-million deaths annually worldwide. A better understanding of the molecular processes governing tumor formation and progression is crucial to improve current diagnostic and prognostic tools as well as to develop more personalized treatment strategies. Tumors are highly complex and heterogeneous structures in which growth and dissemination is not only governed by the cancer cells intrinsic mechanisms, but also by the surrounding tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) emerge as predominant TME components and key players in the generation of permissive conditions that ultimately impact in tumor progression and metastatic dissemination. Although CAFs were initially considered a consequence of tumor development, it is now well established that they actively contribute to numerous cancer hallmarks i.e., tumor cell growth, migration and invasion, cancer cell stemness, angiogenesis, metabolic reprograming, inflammation, and immune system modulation. In this scenario, therapeutic strategies targeting CAF functions could potentially have a major impact in cancer therapeutics, providing avenues for new treatment options or for improving efficacy in established approaches. This review is focused on thoroughly dissecting existing evidences supporting the contribution of CAFs in HNC biology with an emphasis on current knowledge of the key molecules and pathways involved in CAF-tumor crosstalk, and their potential as novel biomarkers and/or therapeutic targets to effectively interfere the tumor-stroma crosstalk for HNC patients benefit. involved in CAF-tumor crosstalk, and their potential as novel biomarkers and/or therapeutic targets to effec- tively interfere the tumor-stroma crosstalk for HNC patients benefit
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10902/30085
url https://hdl.handle.net/10902/30085
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Editions Scientifiques Elsevier
publisher.none.fl_str_mv Editions Scientifiques Elsevier
dc.source.none.fl_str_mv Biomedicine and Pharmacotherapy, 2023, 161, 114502
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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