Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels

Russo, E. (Erica)|||/items/fe1c92f7-6d9b-42b1-9c37-74ddcc44e1cf; Teijeira-Sánchez, A. (Álvaro)|||/items/8a954ec4-8458-46ea-b8e6-3165119bef30; Vaahtomeri, K. (Kari)|||/items/181e7423-fdb8-443d-851e-7f21f827e47a; Willrodt, A.H. (Ann Helen)|||/items/21d35f9e-f5f8-4ee3-84a3-dfed662c8c32; Bloch, J.S. (Joël S.)|||/items/b6e4564b-3ede-4dfa-99df-ab4c3ec15719; Nitschke, M. (Maximilian)|||/items/c4074265-0f99-4f55-ab25-fd2b454890e5; Santambrogio, L. (Laura)|||/items/f865fa23-f49d-4d2c-befb-56ed50a4b194; Kerjaschki, D. (Dontscho)|||/items/405ce74c-a753-47ba-8465-2470249e7c00; Sixt, M. (Michael)|||/items/2496cec2-d060-4ceb-859e-4fb0da3f5989; Halin, C. (Cornelia)|||/items/2fdf36e5-074a-4512-8ccd-7759eff77076

Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels

To induce adaptive immunity, dendritic cells (DCs) migrate through afferent lymphatic vessels (LVs) to draining lymph nodes (dLNs). This process occurs in several consecutive steps. Upon entry into lymphatic capillaries, DCs first actively crawl into downstream collecting vessels. From there, they a...

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Detalles Bibliográficos
Autores:	Russo, E. (Erica)\|\|\|/items/fe1c92f7-6d9b-42b1-9c37-74ddcc44e1cf, Teijeira-Sánchez, A. (Álvaro)\|\|\|/items/8a954ec4-8458-46ea-b8e6-3165119bef30, Vaahtomeri, K. (Kari)\|\|\|/items/181e7423-fdb8-443d-851e-7f21f827e47a, Willrodt, A.H. (Ann Helen)\|\|\|/items/21d35f9e-f5f8-4ee3-84a3-dfed662c8c32, Bloch, J.S. (Joël S.)\|\|\|/items/b6e4564b-3ede-4dfa-99df-ab4c3ec15719, Nitschke, M. (Maximilian)\|\|\|/items/c4074265-0f99-4f55-ab25-fd2b454890e5, Santambrogio, L. (Laura)\|\|\|/items/f865fa23-f49d-4d2c-befb-56ed50a4b194, Kerjaschki, D. (Dontscho)\|\|\|/items/405ce74c-a753-47ba-8465-2470249e7c00, Sixt, M. (Michael)\|\|\|/items/2496cec2-d060-4ceb-859e-4fb0da3f5989, Halin, C. (Cornelia)\|\|\|/items/2fdf36e5-074a-4512-8ccd-7759eff77076
Tipo de recurso:	artículo
Fecha de publicación:	2016
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/122988
Acceso en línea:	https://hdl.handle.net/10171/122988
Access Level:	acceso abierto
Palabra clave:	Dendritic CCL21 Lymphatics Migration Immunity

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spelling	Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic VesselsRusso, E. (Erica)\|\|\|/items/fe1c92f7-6d9b-42b1-9c37-74ddcc44e1cfTeijeira-Sánchez, A. (Álvaro)\|\|\|/items/8a954ec4-8458-46ea-b8e6-3165119bef30Vaahtomeri, K. (Kari)\|\|\|/items/181e7423-fdb8-443d-851e-7f21f827e47aWillrodt, A.H. (Ann Helen)\|\|\|/items/21d35f9e-f5f8-4ee3-84a3-dfed662c8c32Bloch, J.S. (Joël S.)\|\|\|/items/b6e4564b-3ede-4dfa-99df-ab4c3ec15719Nitschke, M. (Maximilian)\|\|\|/items/c4074265-0f99-4f55-ab25-fd2b454890e5Santambrogio, L. (Laura)\|\|\|/items/f865fa23-f49d-4d2c-befb-56ed50a4b194Kerjaschki, D. (Dontscho)\|\|\|/items/405ce74c-a753-47ba-8465-2470249e7c00Sixt, M. (Michael)\|\|\|/items/2496cec2-d060-4ceb-859e-4fb0da3f5989Halin, C. (Cornelia)\|\|\|/items/2fdf36e5-074a-4512-8ccd-7759eff77076DendriticCCL21LymphaticsMigrationImmunityTo induce adaptive immunity, dendritic cells (DCs) migrate through afferent lymphatic vessels (LVs) to draining lymph nodes (dLNs). This process occurs in several consecutive steps. Upon entry into lymphatic capillaries, DCs first actively crawl into downstream collecting vessels. From there, they are next passively and rapidly transported to the dLN by lymph flow. Here, we describe a role for the chemokine CCL21 in intralymphatic DC crawling. Performing time-lapse imaging in murine skin, we found that blockade of CCL21-but not the absence of lymph flow-completely abolished DC migration from capillaries toward collecting vessels and reduced the ability of intralymphatic DCs to emigrate from skin. Moreover, we found that in vitro low laminar flow established a CCL21 gradient along lymphatic endothelial monolayers, thereby inducing downstream-directed DC migration. These findings reveal a role for intralymphatic CCL21 in promoting DC trafficking to dLNs, through the formation of a flow-induced gradient.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20162016-01-0120162016-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/122988reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1229882026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels
title	Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels
spellingShingle	Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels Russo, E. (Erica)\|\|\|/items/fe1c92f7-6d9b-42b1-9c37-74ddcc44e1cf Dendritic CCL21 Lymphatics Migration Immunity
title_short	Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels
title_full	Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels
title_fullStr	Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels
title_full_unstemmed	Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels
title_sort	Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels
dc.creator.none.fl_str_mv	Russo, E. (Erica)\|\|\|/items/fe1c92f7-6d9b-42b1-9c37-74ddcc44e1cf Teijeira-Sánchez, A. (Álvaro)\|\|\|/items/8a954ec4-8458-46ea-b8e6-3165119bef30 Vaahtomeri, K. (Kari)\|\|\|/items/181e7423-fdb8-443d-851e-7f21f827e47a Willrodt, A.H. (Ann Helen)\|\|\|/items/21d35f9e-f5f8-4ee3-84a3-dfed662c8c32 Bloch, J.S. (Joël S.)\|\|\|/items/b6e4564b-3ede-4dfa-99df-ab4c3ec15719 Nitschke, M. (Maximilian)\|\|\|/items/c4074265-0f99-4f55-ab25-fd2b454890e5 Santambrogio, L. (Laura)\|\|\|/items/f865fa23-f49d-4d2c-befb-56ed50a4b194 Kerjaschki, D. (Dontscho)\|\|\|/items/405ce74c-a753-47ba-8465-2470249e7c00 Sixt, M. (Michael)\|\|\|/items/2496cec2-d060-4ceb-859e-4fb0da3f5989 Halin, C. (Cornelia)\|\|\|/items/2fdf36e5-074a-4512-8ccd-7759eff77076
author	Russo, E. (Erica)\|\|\|/items/fe1c92f7-6d9b-42b1-9c37-74ddcc44e1cf
author_facet	Russo, E. (Erica)\|\|\|/items/fe1c92f7-6d9b-42b1-9c37-74ddcc44e1cf Teijeira-Sánchez, A. (Álvaro)\|\|\|/items/8a954ec4-8458-46ea-b8e6-3165119bef30 Vaahtomeri, K. (Kari)\|\|\|/items/181e7423-fdb8-443d-851e-7f21f827e47a Willrodt, A.H. (Ann Helen)\|\|\|/items/21d35f9e-f5f8-4ee3-84a3-dfed662c8c32 Bloch, J.S. (Joël S.)\|\|\|/items/b6e4564b-3ede-4dfa-99df-ab4c3ec15719 Nitschke, M. (Maximilian)\|\|\|/items/c4074265-0f99-4f55-ab25-fd2b454890e5 Santambrogio, L. (Laura)\|\|\|/items/f865fa23-f49d-4d2c-befb-56ed50a4b194 Kerjaschki, D. (Dontscho)\|\|\|/items/405ce74c-a753-47ba-8465-2470249e7c00 Sixt, M. (Michael)\|\|\|/items/2496cec2-d060-4ceb-859e-4fb0da3f5989 Halin, C. (Cornelia)\|\|\|/items/2fdf36e5-074a-4512-8ccd-7759eff77076
author_role	author
author2	Teijeira-Sánchez, A. (Álvaro)\|\|\|/items/8a954ec4-8458-46ea-b8e6-3165119bef30 Vaahtomeri, K. (Kari)\|\|\|/items/181e7423-fdb8-443d-851e-7f21f827e47a Willrodt, A.H. (Ann Helen)\|\|\|/items/21d35f9e-f5f8-4ee3-84a3-dfed662c8c32 Bloch, J.S. (Joël S.)\|\|\|/items/b6e4564b-3ede-4dfa-99df-ab4c3ec15719 Nitschke, M. (Maximilian)\|\|\|/items/c4074265-0f99-4f55-ab25-fd2b454890e5 Santambrogio, L. (Laura)\|\|\|/items/f865fa23-f49d-4d2c-befb-56ed50a4b194 Kerjaschki, D. (Dontscho)\|\|\|/items/405ce74c-a753-47ba-8465-2470249e7c00 Sixt, M. (Michael)\|\|\|/items/2496cec2-d060-4ceb-859e-4fb0da3f5989 Halin, C. (Cornelia)\|\|\|/items/2fdf36e5-074a-4512-8ccd-7759eff77076
author2_role	author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Dendritic CCL21 Lymphatics Migration Immunity
topic	Dendritic CCL21 Lymphatics Migration Immunity
description	To induce adaptive immunity, dendritic cells (DCs) migrate through afferent lymphatic vessels (LVs) to draining lymph nodes (dLNs). This process occurs in several consecutive steps. Upon entry into lymphatic capillaries, DCs first actively crawl into downstream collecting vessels. From there, they are next passively and rapidly transported to the dLN by lymph flow. Here, we describe a role for the chemokine CCL21 in intralymphatic DC crawling. Performing time-lapse imaging in murine skin, we found that blockade of CCL21-but not the absence of lymph flow-completely abolished DC migration from capillaries toward collecting vessels and reduced the ability of intralymphatic DCs to emigrate from skin. Moreover, we found that in vitro low laminar flow established a CCL21 gradient along lymphatic endothelial monolayers, thereby inducing downstream-directed DC migration. These findings reveal a role for intralymphatic CCL21 in promoting DC trafficking to dLNs, through the formation of a flow-induced gradient.
publishDate	2016
dc.date.none.fl_str_mv	2016 2016-01-01 2016 2016-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/122988
url	https://hdl.handle.net/10171/122988
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.811543

Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels

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