Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity

Changes in myocardial stiffness may represent a valuable biomarker for early tissue injury or adverse remodeling. In this study, we developed and validated a novel transducer-free magnetic resonance elastography (MRE) approach for quantifying myocardial biomechanics using aortic valve closure-induce...

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Autores: Troelstra, Marian Amber, Runge, Jurgen Henk, Burnhope, Emma, Polcaro, Alessandro, Guenthner, Christian, Schneider, Torben, Razavi, Reza, Ismail, Tevfik F., Martorell López, Jordi, Sinkus, Ralph
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.14342/4099
Acceso en línea:http://hdl.handle.net/20.500.14342/4099
https://doi.org/10.1038/s41598-020-79231-z
Access Level:acceso abierto
Palabra clave:Miocarditis
Ressonància magnètica
Imatgeria per ressonància magnètica
Cardiologia
Sistema cardiovascular--Malalties
Translational research
616.1
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spelling Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocityTroelstra, Marian AmberRunge, Jurgen HenkBurnhope, EmmaPolcaro, AlessandroGuenthner, ChristianSchneider, TorbenRazavi, RezaIsmail, Tevfik F.Martorell López, JordiSinkus, RalphMiocarditisRessonància magnèticaImatgeria per ressonància magnèticaCardiologiaSistema cardiovascular--MalaltiesTranslational research616.1Changes in myocardial stiffness may represent a valuable biomarker for early tissue injury or adverse remodeling. In this study, we developed and validated a novel transducer-free magnetic resonance elastography (MRE) approach for quantifying myocardial biomechanics using aortic valve closure-induced shear waves. Using motion-sensitized two-dimensional pencil beams, septal shear waves were imaged at high temporal resolution. Shear wave speed was measured using time-of-flight of waves travelling between two pencil beams and corrected for geometrical biases. After validation in phantoms, results from twelve healthy volunteers and five cardiac patients (two left ventricular hypertrophy, two myocardial infarcts, and one without confirmed pathology) were obtained. Torsional shear wave speed in the phantom was 3.0 ± 0.1 m/s, corresponding with reference speeds of 2.8 ± 0.1 m/s. Geometrically-biased flexural shear wave speed was 1.9 ± 0.1 m/s, corresponding with simulation values of 2.0 m/s. Corrected septal shear wave speeds were significantly higher in patients than healthy volunteers [14.1 (11.0–15.8) m/s versus 3.6 (2.7–4.3) m/s, p = 0.001]. The interobserver 95%-limits-of-agreement in healthy volunteers were ± 1.3 m/s and interstudy 95%-limits-of-agreement − 0.7 to 1.2 m/s. In conclusion, myocardial shear wave speed can be measured using aortic valve closure-induced shear waves, with cardiac patients showing significantly higher shear wave speeds than healthy volunteers. This non-invasive measure may provide valuable insights into the pathophysiology of heart failure.info:eu-repo/semantics/publishedVersionSpringer NatureUniversitat Ramon Llull. IQS2021info:eu-repo/semantics/article14 p.http://hdl.handle.net/20.500.14342/4099https://doi.org/10.1038/s41598-020-79231-zreponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésScientific Reportsinfo:eu-repo/grantAgreement/EC/Grant No 668039/info:eu-repo/grantAgreement/EPSRC/EP/N011554info:eu-repo/grantAgreement/British Council/Newton Fund Institutional Links/172707526info:eu-repo/grantAgreement/EPSRC i NIHR/WT 203148/Z© L'autor/aAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.14342/40992026-05-29T05:05:01Z
dc.title.none.fl_str_mv Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity
title Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity
spellingShingle Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity
Troelstra, Marian Amber
Miocarditis
Ressonància magnètica
Imatgeria per ressonància magnètica
Cardiologia
Sistema cardiovascular--Malalties
Translational research
616.1
title_short Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity
title_full Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity
title_fullStr Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity
title_full_unstemmed Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity
title_sort Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity
dc.creator.none.fl_str_mv Troelstra, Marian Amber
Runge, Jurgen Henk
Burnhope, Emma
Polcaro, Alessandro
Guenthner, Christian
Schneider, Torben
Razavi, Reza
Ismail, Tevfik F.
Martorell López, Jordi
Sinkus, Ralph
author Troelstra, Marian Amber
author_facet Troelstra, Marian Amber
Runge, Jurgen Henk
Burnhope, Emma
Polcaro, Alessandro
Guenthner, Christian
Schneider, Torben
Razavi, Reza
Ismail, Tevfik F.
Martorell López, Jordi
Sinkus, Ralph
author_role author
author2 Runge, Jurgen Henk
Burnhope, Emma
Polcaro, Alessandro
Guenthner, Christian
Schneider, Torben
Razavi, Reza
Ismail, Tevfik F.
Martorell López, Jordi
Sinkus, Ralph
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. IQS
dc.subject.none.fl_str_mv Miocarditis
Ressonància magnètica
Imatgeria per ressonància magnètica
Cardiologia
Sistema cardiovascular--Malalties
Translational research
616.1
topic Miocarditis
Ressonància magnètica
Imatgeria per ressonància magnètica
Cardiologia
Sistema cardiovascular--Malalties
Translational research
616.1
description Changes in myocardial stiffness may represent a valuable biomarker for early tissue injury or adverse remodeling. In this study, we developed and validated a novel transducer-free magnetic resonance elastography (MRE) approach for quantifying myocardial biomechanics using aortic valve closure-induced shear waves. Using motion-sensitized two-dimensional pencil beams, septal shear waves were imaged at high temporal resolution. Shear wave speed was measured using time-of-flight of waves travelling between two pencil beams and corrected for geometrical biases. After validation in phantoms, results from twelve healthy volunteers and five cardiac patients (two left ventricular hypertrophy, two myocardial infarcts, and one without confirmed pathology) were obtained. Torsional shear wave speed in the phantom was 3.0 ± 0.1 m/s, corresponding with reference speeds of 2.8 ± 0.1 m/s. Geometrically-biased flexural shear wave speed was 1.9 ± 0.1 m/s, corresponding with simulation values of 2.0 m/s. Corrected septal shear wave speeds were significantly higher in patients than healthy volunteers [14.1 (11.0–15.8) m/s versus 3.6 (2.7–4.3) m/s, p = 0.001]. The interobserver 95%-limits-of-agreement in healthy volunteers were ± 1.3 m/s and interstudy 95%-limits-of-agreement − 0.7 to 1.2 m/s. In conclusion, myocardial shear wave speed can be measured using aortic valve closure-induced shear waves, with cardiac patients showing significantly higher shear wave speeds than healthy volunteers. This non-invasive measure may provide valuable insights into the pathophysiology of heart failure.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/4099
https://doi.org/10.1038/s41598-020-79231-z
url http://hdl.handle.net/20.500.14342/4099
https://doi.org/10.1038/s41598-020-79231-z
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Scientific Reports
info:eu-repo/grantAgreement/EC/Grant No 668039/
info:eu-repo/grantAgreement/EPSRC/EP/N011554
info:eu-repo/grantAgreement/British Council/Newton Fund Institutional Links/172707526
info:eu-repo/grantAgreement/EPSRC i NIHR/WT 203148/Z
dc.rights.none.fl_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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