Potential role of new molecular plasma signatures on cardiovascular risk stratification in asymptomatic individuals

The evaluation of cardiovascular (CV) risk is based on equations derived from epidemiological data in individuals beyond the limits of middle age such as the Framingham and SCORE risk assessments. Lifetime Risk calculator (QRisk®), estimates CV risk throughout a subjects’ lifetime, allowing those. A...

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Autores: Baldán Martín, Montserrat, López, Juan Antonio, Corbacho Alonso, Nerea, Martínez, Paula J., Rodríguez Sánchez, Elena, Mouriño Álvarez, Laura, Sastre Oliva, Tamara, Martín Rojas, Tatiana, Ruilope Urioste, Luis Miguel, Barderas, María G., Et al.
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/7265
Acceso en línea:http://hdl.handle.net/11268/7265
Access Level:acceso abierto
Palabra clave:Cardiopatía coronaria
Medicina preventiva
Enfermedad cardiovascular
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spelling Potential role of new molecular plasma signatures on cardiovascular risk stratification in asymptomatic individualsBaldán Martín, MontserratLópez, Juan AntonioCorbacho Alonso, NereaMartínez, Paula J.Rodríguez Sánchez, ElenaMouriño Álvarez, LauraSastre Oliva, TamaraMartín Rojas, TatianaRuilope Urioste, Luis MiguelBarderas, María G.Et al.Cardiopatía coronariaMedicina preventivaEnfermedad cardiovascularMedicina preventivaThe evaluation of cardiovascular (CV) risk is based on equations derived from epidemiological data in individuals beyond the limits of middle age such as the Framingham and SCORE risk assessments. Lifetime Risk calculator (QRisk®), estimates CV risk throughout a subjects’ lifetime, allowing those. A more aggressive and earlier intervention to be identified and offered protection from the consequences of CV and renal disease. The search for molecular profiles in young people that allow a correct stratification of CV risk would be of great interest to adopt preventive therapeutic measures in individuals at high CV risk. To improve the selection of subjects susceptible to intervention with aged between 30–50 years, we have employed a multiple proteomic strategy to search for new markers of early CV disease or reported CV events and to evaluate their relationship with Lifetime Risk. Blood samples from 71 patients were classified into 3 groups according to their CV risk (healthy, with CV risk factors and with a previously reported CV event subjects) and they were analyzed using a high through quantitative proteomics approach. This strategy allowed three different proteomic signatures to be defined, two of which were related to CV stratification and the third one involved markers of organ damage.20182018-05-1420182018-01-0120182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/11268/7265reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/72652026-06-11T12:41:27Z
dc.title.none.fl_str_mv Potential role of new molecular plasma signatures on cardiovascular risk stratification in asymptomatic individuals
title Potential role of new molecular plasma signatures on cardiovascular risk stratification in asymptomatic individuals
spellingShingle Potential role of new molecular plasma signatures on cardiovascular risk stratification in asymptomatic individuals
Baldán Martín, Montserrat
Cardiopatía coronaria
Medicina preventiva
Enfermedad cardiovascular
Medicina preventiva
title_short Potential role of new molecular plasma signatures on cardiovascular risk stratification in asymptomatic individuals
title_full Potential role of new molecular plasma signatures on cardiovascular risk stratification in asymptomatic individuals
title_fullStr Potential role of new molecular plasma signatures on cardiovascular risk stratification in asymptomatic individuals
title_full_unstemmed Potential role of new molecular plasma signatures on cardiovascular risk stratification in asymptomatic individuals
title_sort Potential role of new molecular plasma signatures on cardiovascular risk stratification in asymptomatic individuals
dc.creator.none.fl_str_mv Baldán Martín, Montserrat
López, Juan Antonio
Corbacho Alonso, Nerea
Martínez, Paula J.
Rodríguez Sánchez, Elena
Mouriño Álvarez, Laura
Sastre Oliva, Tamara
Martín Rojas, Tatiana
Ruilope Urioste, Luis Miguel
Barderas, María G.
Et al.
author Baldán Martín, Montserrat
author_facet Baldán Martín, Montserrat
López, Juan Antonio
Corbacho Alonso, Nerea
Martínez, Paula J.
Rodríguez Sánchez, Elena
Mouriño Álvarez, Laura
Sastre Oliva, Tamara
Martín Rojas, Tatiana
Ruilope Urioste, Luis Miguel
Barderas, María G.
Et al.
author_role author
author2 López, Juan Antonio
Corbacho Alonso, Nerea
Martínez, Paula J.
Rodríguez Sánchez, Elena
Mouriño Álvarez, Laura
Sastre Oliva, Tamara
Martín Rojas, Tatiana
Ruilope Urioste, Luis Miguel
Barderas, María G.
Et al.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Cardiopatía coronaria
Medicina preventiva
Enfermedad cardiovascular
Medicina preventiva
topic Cardiopatía coronaria
Medicina preventiva
Enfermedad cardiovascular
Medicina preventiva
description The evaluation of cardiovascular (CV) risk is based on equations derived from epidemiological data in individuals beyond the limits of middle age such as the Framingham and SCORE risk assessments. Lifetime Risk calculator (QRisk®), estimates CV risk throughout a subjects’ lifetime, allowing those. A more aggressive and earlier intervention to be identified and offered protection from the consequences of CV and renal disease. The search for molecular profiles in young people that allow a correct stratification of CV risk would be of great interest to adopt preventive therapeutic measures in individuals at high CV risk. To improve the selection of subjects susceptible to intervention with aged between 30–50 years, we have employed a multiple proteomic strategy to search for new markers of early CV disease or reported CV events and to evaluate their relationship with Lifetime Risk. Blood samples from 71 patients were classified into 3 groups according to their CV risk (healthy, with CV risk factors and with a previously reported CV event subjects) and they were analyzed using a high through quantitative proteomics approach. This strategy allowed three different proteomic signatures to be defined, two of which were related to CV stratification and the third one involved markers of organ damage.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-05-14
2018
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/7265
url http://hdl.handle.net/11268/7265
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
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