Frontal Hypoactivation on Functional Magnetic Resonance Imaging in Working Memory after Severe Diffuse Traumatic Brain Injury

Working memory is frequently impaired after traumatic brain injury (TBI). The present study aimed to investigate working memory deficits in patients with diffuse axonal injury and to determine the contribution of cerebral activation dysfunctions to them. Eighteen patients with severe TBI and 14 heal...

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Autores: Sánchez Carrión, Rocío, Vendrell i Gómez, Pere, Junqué i Plaja, Carme, 1955-, Fernández Espejo, Davinia, Falcón Falcón, Carles Maria, Bargalló Alabart, Núria, Roig Rovira, María Teresa, Enseñat Cantallops, Antònia, Bernabeu Guitart, Montserrat
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/223694
Acceso en línea:https://hdl.handle.net/2445/223694
Access Level:acceso abierto
Palabra clave:Lòbul frontal
Imatges per ressonància magnètica
Lesions cerebrals
Frontal lobe
Magnetic resonance imaging
Brain damage
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spelling Frontal Hypoactivation on Functional Magnetic Resonance Imaging in Working Memory after Severe Diffuse Traumatic Brain InjurySánchez Carrión, RocíoVendrell i Gómez, PereJunqué i Plaja, Carme, 1955-Fernández Espejo, DaviniaFalcón Falcón, Carles MariaBargalló Alabart, NúriaRoig Rovira, María TeresaEnseñat Cantallops, AntòniaBernabeu Guitart, MontserratLòbul frontalImatges per ressonància magnèticaLesions cerebralsFrontal lobeMagnetic resonance imagingBrain damageWorking memory is frequently impaired after traumatic brain injury (TBI). The present study aimed to investigate working memory deficits in patients with diffuse axonal injury and to determine the contribution of cerebral activation dysfunctions to them. Eighteen patients with severe TBI and 14 healthy controls matched for age and gender were included in the study. TBI patients were selected according to signs of diffuse axonal injury on computed tomography (CT) and without any evidence of focal lesions on MRI clinical examination. Functional magnetic resonance (fMRI) was used to assess brain activation during n-back tasks (0-, 2-, and 3-back). Compared to controls, the TBI group showed significant working memory impairment on the Digits Backwards (p = 0.022) and Letter-Number Sequencing subtests from the WAIS-III (p < 0.001) under the 2-back (p = 0.008) and 3-back (p = 0.017) conditions. Both groups engaged bilateral fronto-parietal regions known to be involved in working memory, although patients showed less cerebral activation than did controls. Decreased activation in TBI patients compared to controls was observed mainly in the right superior and middle frontal cortex. The correlation patterns differed between patients and controls: while the control group showed a negative correlation between performance and activation in prefrontal cortex (PFC), TBI patients presented a positive correlation in right parietal and left parahippocampus for the low and high working memory load, respectively. In conclusion, severe TBI patients with diffuse brain damage show a pattern of cerebral hypoactivation in the right middle and superior frontal regions during working memory tasks, and also present an impaired pattern of performance correlations.Mary Ann Liebert2025202520082025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion16 p.application/pdfhttps://hdl.handle.net/2445/223694Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1089/neu.2007.0417Journal of Neurotrauma, 2008, vol. 25, num.5, p. 479-494https://doi.org/10.1089/neu.2007.0417(c) Mary Ann Liebert, 2008info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2236942026-05-29T05:05:01Z
dc.title.none.fl_str_mv Frontal Hypoactivation on Functional Magnetic Resonance Imaging in Working Memory after Severe Diffuse Traumatic Brain Injury
title Frontal Hypoactivation on Functional Magnetic Resonance Imaging in Working Memory after Severe Diffuse Traumatic Brain Injury
spellingShingle Frontal Hypoactivation on Functional Magnetic Resonance Imaging in Working Memory after Severe Diffuse Traumatic Brain Injury
Sánchez Carrión, Rocío
Lòbul frontal
Imatges per ressonància magnètica
Lesions cerebrals
Frontal lobe
Magnetic resonance imaging
Brain damage
title_short Frontal Hypoactivation on Functional Magnetic Resonance Imaging in Working Memory after Severe Diffuse Traumatic Brain Injury
title_full Frontal Hypoactivation on Functional Magnetic Resonance Imaging in Working Memory after Severe Diffuse Traumatic Brain Injury
title_fullStr Frontal Hypoactivation on Functional Magnetic Resonance Imaging in Working Memory after Severe Diffuse Traumatic Brain Injury
title_full_unstemmed Frontal Hypoactivation on Functional Magnetic Resonance Imaging in Working Memory after Severe Diffuse Traumatic Brain Injury
title_sort Frontal Hypoactivation on Functional Magnetic Resonance Imaging in Working Memory after Severe Diffuse Traumatic Brain Injury
dc.creator.none.fl_str_mv Sánchez Carrión, Rocío
Vendrell i Gómez, Pere
Junqué i Plaja, Carme, 1955-
Fernández Espejo, Davinia
Falcón Falcón, Carles Maria
Bargalló Alabart, Núria
Roig Rovira, María Teresa
Enseñat Cantallops, Antònia
Bernabeu Guitart, Montserrat
author Sánchez Carrión, Rocío
author_facet Sánchez Carrión, Rocío
Vendrell i Gómez, Pere
Junqué i Plaja, Carme, 1955-
Fernández Espejo, Davinia
Falcón Falcón, Carles Maria
Bargalló Alabart, Núria
Roig Rovira, María Teresa
Enseñat Cantallops, Antònia
Bernabeu Guitart, Montserrat
author_role author
author2 Vendrell i Gómez, Pere
Junqué i Plaja, Carme, 1955-
Fernández Espejo, Davinia
Falcón Falcón, Carles Maria
Bargalló Alabart, Núria
Roig Rovira, María Teresa
Enseñat Cantallops, Antònia
Bernabeu Guitart, Montserrat
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Lòbul frontal
Imatges per ressonància magnètica
Lesions cerebrals
Frontal lobe
Magnetic resonance imaging
Brain damage
topic Lòbul frontal
Imatges per ressonància magnètica
Lesions cerebrals
Frontal lobe
Magnetic resonance imaging
Brain damage
description Working memory is frequently impaired after traumatic brain injury (TBI). The present study aimed to investigate working memory deficits in patients with diffuse axonal injury and to determine the contribution of cerebral activation dysfunctions to them. Eighteen patients with severe TBI and 14 healthy controls matched for age and gender were included in the study. TBI patients were selected according to signs of diffuse axonal injury on computed tomography (CT) and without any evidence of focal lesions on MRI clinical examination. Functional magnetic resonance (fMRI) was used to assess brain activation during n-back tasks (0-, 2-, and 3-back). Compared to controls, the TBI group showed significant working memory impairment on the Digits Backwards (p = 0.022) and Letter-Number Sequencing subtests from the WAIS-III (p < 0.001) under the 2-back (p = 0.008) and 3-back (p = 0.017) conditions. Both groups engaged bilateral fronto-parietal regions known to be involved in working memory, although patients showed less cerebral activation than did controls. Decreased activation in TBI patients compared to controls was observed mainly in the right superior and middle frontal cortex. The correlation patterns differed between patients and controls: while the control group showed a negative correlation between performance and activation in prefrontal cortex (PFC), TBI patients presented a positive correlation in right parietal and left parahippocampus for the low and high working memory load, respectively. In conclusion, severe TBI patients with diffuse brain damage show a pattern of cerebral hypoactivation in the right middle and superior frontal regions during working memory tasks, and also present an impaired pattern of performance correlations.
publishDate 2008
dc.date.none.fl_str_mv 2008
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/223694
url https://hdl.handle.net/2445/223694
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1089/neu.2007.0417
Journal of Neurotrauma, 2008, vol. 25, num.5, p. 479-494
https://doi.org/10.1089/neu.2007.0417
dc.rights.none.fl_str_mv (c) Mary Ann Liebert, 2008
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Mary Ann Liebert, 2008
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16 p.
application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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