Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma.

Peña-Asensio, J.; Calvo, H.; Torralba, M.; Miquel, J.; Sanz-de-Villalobos, E.; Larrubia, J.-R. Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma. Cancers 2021, 13, 1922.

Detalhes bibliográficos
Autores: Peña Asensio, Julia, Calvo Sánchez, Henar, Torralba González de Suso, Miguel|||0000-0003-2166-7405, Miquel Plaza, Joaquín, Sanz de Villalobos, Eduardo, Larrubia Marfil, Juan Ramón
Tipo de documento: artigo
Data de publicação:2021
País:España
Recursos:Universidad de Alcalá (UAH)
Repositório:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglês
OAI Identifier:oai:ebuah.uah.es:10017/50894
Acesso em linha:http://hdl.handle.net/10017/50894
https://dx.doi.org/10.3390/cancers13081922
Access Level:Acceso aberto
Palavra-chave:Hepatocellular carcinoma
Immunotherapy
PD-1
PD-L1
Immune check-point inhibitor
Combination therapy
CD8 T cell response
Medicina
Medicine
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spelling Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma.Peña Asensio, JuliaCalvo Sánchez, HenarTorralba González de Suso, Miguel|||0000-0003-2166-7405Miquel Plaza, JoaquínSanz de Villalobos, EduardoLarrubia Marfil, Juan RamónHepatocellular carcinomaImmunotherapyPD-1PD-L1Immune check-point inhibitorCombination therapyCD8 T cell responseMedicinaMedicinePeña-Asensio, J.; Calvo, H.; Torralba, M.; Miquel, J.; Sanz-de-Villalobos, E.; Larrubia, J.-R. Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma. Cancers 2021, 13, 1922.Thirty to fifty percent of hepatocellular carcinomas (HCC) display an immune class genetic signature. In this type of tumor, HCC-specific CD8 T cells carry out a key role in HCC control. Those potential reactive HCC-specific CD8 T cells recognize either HCC immunogenic neoantigens or aberrantly expressed host’s antigens, but they become progressively exhausted or deleted. These cells express the negative immunoregulatory checkpoint programmed cell death protein 1 (PD-1) which impairs T cell receptor signaling by blocking the CD28 positive co-stimulatory signal. The pool of CD8 cells sensitive to anti-PD-1/PD-L1 treatment is the PD-1dim memory-like precursor pool that gives rise to the effector subset involved in HCC control. Due to the epigenetic imprints that are transmitted to the next generation, the effect of PD-1 blockade is transient, and repeated treatments lead to tumor resistance. During long-lasting disease, besides the TCR signaling impairment, T cells develop other failures that should be also set-up to increase T cell reactivity. Therefore, several PD-1 blockade-based combinatory therapies are currently under investigation such as adding antiangiogenics, anti-TGFβ1, blockade of other negative immune checkpoints, or increasing HCC antigen presentation. The effect of these combinations on CD8+ T cells is discussed in this review.Instituto de Salud Carlos IIIEuropean Regional Development Fund (ERDF)European UnionGilead Fellowship Programme20212021-04-16journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/50894https://dx.doi.org/10.3390/cancers13081922reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PI19%2F00206Gilead Sciences Gilead Fellowship Program in HIV & Hepatitis GLD14%2F00217 (JRL)Gilead Sciences Gilead Fellowship Program in HIV & Hepatitis GLD16 ESopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/508942026-06-18T11:13:07Z
dc.title.none.fl_str_mv Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma.
title Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma.
spellingShingle Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma.
Peña Asensio, Julia
Hepatocellular carcinoma
Immunotherapy
PD-1
PD-L1
Immune check-point inhibitor
Combination therapy
CD8 T cell response
Medicina
Medicine
title_short Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma.
title_full Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma.
title_fullStr Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma.
title_full_unstemmed Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma.
title_sort Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma.
dc.creator.none.fl_str_mv Peña Asensio, Julia
Calvo Sánchez, Henar
Torralba González de Suso, Miguel|||0000-0003-2166-7405
Miquel Plaza, Joaquín
Sanz de Villalobos, Eduardo
Larrubia Marfil, Juan Ramón
author Peña Asensio, Julia
author_facet Peña Asensio, Julia
Calvo Sánchez, Henar
Torralba González de Suso, Miguel|||0000-0003-2166-7405
Miquel Plaza, Joaquín
Sanz de Villalobos, Eduardo
Larrubia Marfil, Juan Ramón
author_role author
author2 Calvo Sánchez, Henar
Torralba González de Suso, Miguel|||0000-0003-2166-7405
Miquel Plaza, Joaquín
Sanz de Villalobos, Eduardo
Larrubia Marfil, Juan Ramón
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Hepatocellular carcinoma
Immunotherapy
PD-1
PD-L1
Immune check-point inhibitor
Combination therapy
CD8 T cell response
Medicina
Medicine
topic Hepatocellular carcinoma
Immunotherapy
PD-1
PD-L1
Immune check-point inhibitor
Combination therapy
CD8 T cell response
Medicina
Medicine
description Peña-Asensio, J.; Calvo, H.; Torralba, M.; Miquel, J.; Sanz-de-Villalobos, E.; Larrubia, J.-R. Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8+ T Cell Response in Hepatocellular Carcinoma. Cancers 2021, 13, 1922.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-04-16
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/50894
https://dx.doi.org/10.3390/cancers13081922
url http://hdl.handle.net/10017/50894
https://dx.doi.org/10.3390/cancers13081922
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PI19%2F00206
Gilead Sciences Gilead Fellowship Program in HIV & Hepatitis GLD14%2F00217 (JRL)
Gilead Sciences Gilead Fellowship Program in HIV & Hepatitis GLD16 ES
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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