Outcomes of a paediatric antimicrobial stewardship program in the Emergency Department observation unit of a hospital in Spain [Dataset]

In paediatric emergency departments the use of empirical antimicrobials is very common, even though most infections are caused by viruses, resulting in misuse of antimicrobials. We aimed to assess the impact of a comprehensive antimicrobial stewardship program (ASP) on the optimisation of antimicrob...

Descripción completa

Detalles Bibliográficos
Autores: Suárez Casillas, Paloma, Peñalva, Germán, Guisado-Gil, Ana Belén, González de Boado, Blanca, Hurtado-Mingo, Ángela, Molina, José, Mejías-Trueba, Marta, Lepe, José Antonio, Cisneros, José Miguel, Sánchez-Álvarez, María Jesús
Tipo de recurso: conjunto de datos
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/412212
Acceso en línea:http://hdl.handle.net/10261/412212
Access Level:acceso abierto
Palabra clave:Antimicrobial stewardship program (ASP)
Pediatric emergency department
Antimicrobial use
Defined daily doses
Clinical outcomes
id ES_d30979cc379507fc0b8acbdecb2f6cfc
oai_identifier_str oai:digital.csic.es:10261/412212
network_acronym_str ES
network_name_str España
repository_id_str
spelling Outcomes of a paediatric antimicrobial stewardship program in the Emergency Department observation unit of a hospital in Spain [Dataset]Suárez Casillas, PalomaPeñalva, GermánGuisado-Gil, Ana BelénGonzález de Boado, BlancaHurtado-Mingo, ÁngelaMolina, JoséMejías-Trueba, MartaLepe, José AntonioCisneros, José MiguelSánchez-Álvarez, María JesúsAntimicrobial stewardship program (ASP)Pediatric emergency departmentAntimicrobial useDefined daily dosesClinical outcomesIn paediatric emergency departments the use of empirical antimicrobials is very common, even though most infections are caused by viruses, resulting in misuse of antimicrobials. We aimed to assess the impact of a comprehensive antimicrobial stewardship program (ASP) on the optimisation of antimicrobial prescribing and clinical outcomes in a paediatric Emergency Department Observation Unit (EDOU). A quasi-experimental before-and-after longitudinal study was conducted at the EDOU of a paediatric hospital, over 24 quarters from January 2017 to December 2023, excluding 2020 due to the pandemic and the phase-in period. The ASP intervention included the development and implementation of clinical guidelines, rapid diagnostic tests (RDTs), and staff stabilisation. Data on antimicrobial use and clinical outcomes, such as revisits within 72 h and hospital admissions, were collected and analysed using Bayesian structural time series models. The study included 33,799 patients transferred to the EDOU. Mean antimicrobial consumption significantly decreased from 46.5 ± 12.9 pre-intervention defined daily doses (DDDs) per 100 patients transferred to the Observation Unit (TOs) to 20.1 ± 3.0 DDDs per 100 TOs in the intervention period (p < 0.0001). Significant reductions were observed for amoxicillin-clavulanic acid, amoxicillin, and azithromycin. The percentage of revisits and hospital admissions remained stable for the whole period. The implementation of ASP measures improved antimicrobial prescribing in the paediatric EDOU. These findings support the need for continued efforts in ASP, emphasising the development and implementation of guidelines, RDTs, and staff stabilisation.This study was not supported by any sponsor or funder.Peer reviewedFigshareGuisado-Gil, Ana Belén [0000-0003-0882-9254]Mejías-Trueba, Marta [0000-0003-3819-4966]Cisneros, José Miguel [0000-0001-5001-672X]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262025info:eu-repo/semantics/datasethttp://purl.org/coar/resource_type/c_ddb1application/wordperfect5.1text/csvhttp://hdl.handle.net/10261/412212reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésSuárez Casillas, Paloma; Peñalva, Germán; Guisado-Gil, Ana Belén CSIC ORCID; González de Boado, Blanca; Hurtado-Mingo, Ángela; Molina, José; Mejías-Trueba, Marta; Lepe, José Antonio; Cisneros, José Miguel; Sánchez-Álvarez, María Jesús. Outcomes of a paediatric antimicrobial stewardship program in the Emergency Department observation unit of a hospital in Spain. https://doi.org/10.1080/23744235.2025.2512388. http://hdl.handle.net/10261/412210https://doi.org/10.6084/m9.figshare.29233610Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4122122026-05-22T06:33:51Z
dc.title.none.fl_str_mv Outcomes of a paediatric antimicrobial stewardship program in the Emergency Department observation unit of a hospital in Spain [Dataset]
title Outcomes of a paediatric antimicrobial stewardship program in the Emergency Department observation unit of a hospital in Spain [Dataset]
spellingShingle Outcomes of a paediatric antimicrobial stewardship program in the Emergency Department observation unit of a hospital in Spain [Dataset]
Suárez Casillas, Paloma
Antimicrobial stewardship program (ASP)
Pediatric emergency department
Antimicrobial use
Defined daily doses
Clinical outcomes
title_short Outcomes of a paediatric antimicrobial stewardship program in the Emergency Department observation unit of a hospital in Spain [Dataset]
title_full Outcomes of a paediatric antimicrobial stewardship program in the Emergency Department observation unit of a hospital in Spain [Dataset]
title_fullStr Outcomes of a paediatric antimicrobial stewardship program in the Emergency Department observation unit of a hospital in Spain [Dataset]
title_full_unstemmed Outcomes of a paediatric antimicrobial stewardship program in the Emergency Department observation unit of a hospital in Spain [Dataset]
title_sort Outcomes of a paediatric antimicrobial stewardship program in the Emergency Department observation unit of a hospital in Spain [Dataset]
dc.creator.none.fl_str_mv Suárez Casillas, Paloma
Peñalva, Germán
Guisado-Gil, Ana Belén
González de Boado, Blanca
Hurtado-Mingo, Ángela
Molina, José
Mejías-Trueba, Marta
Lepe, José Antonio
Cisneros, José Miguel
Sánchez-Álvarez, María Jesús
author Suárez Casillas, Paloma
author_facet Suárez Casillas, Paloma
Peñalva, Germán
Guisado-Gil, Ana Belén
González de Boado, Blanca
Hurtado-Mingo, Ángela
Molina, José
Mejías-Trueba, Marta
Lepe, José Antonio
Cisneros, José Miguel
Sánchez-Álvarez, María Jesús
author_role author
author2 Peñalva, Germán
Guisado-Gil, Ana Belén
González de Boado, Blanca
Hurtado-Mingo, Ángela
Molina, José
Mejías-Trueba, Marta
Lepe, José Antonio
Cisneros, José Miguel
Sánchez-Álvarez, María Jesús
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Guisado-Gil, Ana Belén [0000-0003-0882-9254]
Mejías-Trueba, Marta [0000-0003-3819-4966]
Cisneros, José Miguel [0000-0001-5001-672X]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Antimicrobial stewardship program (ASP)
Pediatric emergency department
Antimicrobial use
Defined daily doses
Clinical outcomes
topic Antimicrobial stewardship program (ASP)
Pediatric emergency department
Antimicrobial use
Defined daily doses
Clinical outcomes
description In paediatric emergency departments the use of empirical antimicrobials is very common, even though most infections are caused by viruses, resulting in misuse of antimicrobials. We aimed to assess the impact of a comprehensive antimicrobial stewardship program (ASP) on the optimisation of antimicrobial prescribing and clinical outcomes in a paediatric Emergency Department Observation Unit (EDOU). A quasi-experimental before-and-after longitudinal study was conducted at the EDOU of a paediatric hospital, over 24 quarters from January 2017 to December 2023, excluding 2020 due to the pandemic and the phase-in period. The ASP intervention included the development and implementation of clinical guidelines, rapid diagnostic tests (RDTs), and staff stabilisation. Data on antimicrobial use and clinical outcomes, such as revisits within 72 h and hospital admissions, were collected and analysed using Bayesian structural time series models. The study included 33,799 patients transferred to the EDOU. Mean antimicrobial consumption significantly decreased from 46.5 ± 12.9 pre-intervention defined daily doses (DDDs) per 100 patients transferred to the Observation Unit (TOs) to 20.1 ± 3.0 DDDs per 100 TOs in the intervention period (p < 0.0001). Significant reductions were observed for amoxicillin-clavulanic acid, amoxicillin, and azithromycin. The percentage of revisits and hospital admissions remained stable for the whole period. The implementation of ASP measures improved antimicrobial prescribing in the paediatric EDOU. These findings support the need for continued efforts in ASP, emphasising the development and implementation of guidelines, RDTs, and staff stabilisation.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
http://purl.org/coar/resource_type/c_ddb1
format dataset
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/412212
url http://hdl.handle.net/10261/412212
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Suárez Casillas, Paloma; Peñalva, Germán; Guisado-Gil, Ana Belén CSIC ORCID; González de Boado, Blanca; Hurtado-Mingo, Ángela; Molina, José; Mejías-Trueba, Marta; Lepe, José Antonio; Cisneros, José Miguel; Sánchez-Álvarez, María Jesús. Outcomes of a paediatric antimicrobial stewardship program in the Emergency Department observation unit of a hospital in Spain. https://doi.org/10.1080/23744235.2025.2512388. http://hdl.handle.net/10261/412210
https://doi.org/10.6084/m9.figshare.29233610
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/wordperfect5.1
text/csv
dc.publisher.none.fl_str_mv Figshare
publisher.none.fl_str_mv Figshare
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420425280225280
score 15,812429

Similares en LA Referencia