Prenatal exposure to NO2 and ultrasound measures of fetal growth in the Spanish INMA cohort.

BACKGROUND: Air pollution exposure during pregnancy has been associated with impaired fetal growth. However, few studies have measured fetal biometry longitudinally, remaining unclear as to whether there are windows of special vulnerability. OBJECTIVE: The aim was to investigate the impact of nitrog...

Descripción completa

Detalles Bibliográficos
Autores: Iñiguez, Carmen, Esplugues, Ana, Sunyer Deu, Jordi, Basterrechea, Mikel, Fernández Somoano, Ana, Costa, Olga, Estarlich, Marisa, Aguilera Jiménez, Inmaculada, 1977-, Lertxundi, Aitana, Tardón, Adonina, Guxens Junyent, Mònica, Murcia, Mario, Lopez-Espinosa, Maria-José, Ballester Díez, Ferran, NMA Project
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/25946
Acceso en línea:http://hdl.handle.net/10230/25946
http://dx.doi.org/10.1289/ehp.1409423
Access Level:acceso abierto
Palabra clave:Aire -- Contaminació
Embaràs
id ES_d30163ae63e40b39bcbe35dd62d760e2
oai_identifier_str oai:recercat.cat:10230/25946
network_acronym_str ES
network_name_str España
repository_id_str
spelling Prenatal exposure to NO2 and ultrasound measures of fetal growth in the Spanish INMA cohort.Iñiguez, CarmenEsplugues, AnaSunyer Deu, JordiBasterrechea, MikelFernández Somoano, AnaCosta, OlgaEstarlich, MarisaAguilera Jiménez, Inmaculada, 1977-Lertxundi, AitanaTardón, AdoninaGuxens Junyent, MònicaMurcia, MarioLopez-Espinosa, Maria-JoséBallester Díez, FerranNMA ProjectAire -- ContaminacióEmbaràsBACKGROUND: Air pollution exposure during pregnancy has been associated with impaired fetal growth. However, few studies have measured fetal biometry longitudinally, remaining unclear as to whether there are windows of special vulnerability. OBJECTIVE: The aim was to investigate the impact of nitrogen dioxide (NO2) exposure on fetal and neonatal biometry in the Spanish INMA study. METHODS: Biparietal diameter (BPD), femur length (FL), abdominal circumference (AC), and estimated fetal weight (EFW) were evaluated for up to 2,478 fetuses in each trimester of pregnancy. Size at 12, 20, and 34 weeks of gestation and growth between these points, as well as anthropometry at birth, were assessed by SD scores derived using cohort-specific growth curves. Temporally adjusted land-use regression was used to estimate exposure to NO2 at home addresses for up to 2,415 fetuses. Associations were investigated by linear regression in each cohort and subsequent meta-analysis. RESULTS: A 10-μg/m3 increase in average exposure to NO2 during weeks 0-12 was associated with reduced growth at weeks 0-12 in AC (-2.1%; 95% CI: -3.7, -0.6) and EFW (-1.6%; 95% CI: -3.0, -0.3). The same exposure was inversely associated with reduced growth at weeks 20-34 in BPD (-2.6%; 95% CI: -3.9, -1.2), AC (-1.8%; 95% CI: -3.3, -0.2), and EFW (-2.1%; 95% CI: -3.7, -0.2). A less consistent pattern of association was observed for FL. The negative association of this exposure with BPD and EFW was significantly stronger in smoking versus nonsmoking mothers. CONCLUSIONS: Maternal exposure to NO2 in early pregnancy was associated with reduced fetal growth based on ultrasound measures of growth during pregnancy and measures of size at birth.This study was funded by grants from the European Union: NEWGENERIS FP6-2003-Food-3-A-016320, FP7-ENV-2011 cod 282957, HEALTH.2010.2.4.5-1; and by grants from Spain: Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0031, and FIS-FEDER PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI04/2018, PI04/1436, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI08/1151, PI09/02647, PI09/02311, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/02429, PI14/0891, PI14/1687, and Miguel Servet CP11/00178 and MS13/00054), Conselleria de Sanitat Generalitat Valenciana, Generalitat de Catalunya (CIRIT 1999SGR 00241), Diputación Foral de Guipúzcoa (DFG/004), Departamento de Sanidad y Consumo Gobierno Vasco (2005111093), Obra Social Cajastur, and Oviedo University.National Institute of Environmental Health Sciences (NIEHS)201620162016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/25946http://dx.doi.org/10.1289/ehp.1409423reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésEnvironmental Health Perspectives. 2016 Feb;124(2):235-42info:eu-repo/grantAgreement/EC/FP7/282957info:eu-repo/grantAgreement/EC/FP6/16320Reproduced with permission from Environmental Health perspectivesinfo:eu-repo/semantics/openAccessoai:recercat.cat:10230/259462026-05-29T05:05:01Z
dc.title.none.fl_str_mv Prenatal exposure to NO2 and ultrasound measures of fetal growth in the Spanish INMA cohort.
title Prenatal exposure to NO2 and ultrasound measures of fetal growth in the Spanish INMA cohort.
spellingShingle Prenatal exposure to NO2 and ultrasound measures of fetal growth in the Spanish INMA cohort.
Iñiguez, Carmen
Aire -- Contaminació
Embaràs
title_short Prenatal exposure to NO2 and ultrasound measures of fetal growth in the Spanish INMA cohort.
title_full Prenatal exposure to NO2 and ultrasound measures of fetal growth in the Spanish INMA cohort.
title_fullStr Prenatal exposure to NO2 and ultrasound measures of fetal growth in the Spanish INMA cohort.
title_full_unstemmed Prenatal exposure to NO2 and ultrasound measures of fetal growth in the Spanish INMA cohort.
title_sort Prenatal exposure to NO2 and ultrasound measures of fetal growth in the Spanish INMA cohort.
dc.creator.none.fl_str_mv Iñiguez, Carmen
Esplugues, Ana
Sunyer Deu, Jordi
Basterrechea, Mikel
Fernández Somoano, Ana
Costa, Olga
Estarlich, Marisa
Aguilera Jiménez, Inmaculada, 1977-
Lertxundi, Aitana
Tardón, Adonina
Guxens Junyent, Mònica
Murcia, Mario
Lopez-Espinosa, Maria-José
Ballester Díez, Ferran
NMA Project
author Iñiguez, Carmen
author_facet Iñiguez, Carmen
Esplugues, Ana
Sunyer Deu, Jordi
Basterrechea, Mikel
Fernández Somoano, Ana
Costa, Olga
Estarlich, Marisa
Aguilera Jiménez, Inmaculada, 1977-
Lertxundi, Aitana
Tardón, Adonina
Guxens Junyent, Mònica
Murcia, Mario
Lopez-Espinosa, Maria-José
Ballester Díez, Ferran
NMA Project
author_role author
author2 Esplugues, Ana
Sunyer Deu, Jordi
Basterrechea, Mikel
Fernández Somoano, Ana
Costa, Olga
Estarlich, Marisa
Aguilera Jiménez, Inmaculada, 1977-
Lertxundi, Aitana
Tardón, Adonina
Guxens Junyent, Mònica
Murcia, Mario
Lopez-Espinosa, Maria-José
Ballester Díez, Ferran
NMA Project
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Aire -- Contaminació
Embaràs
topic Aire -- Contaminació
Embaràs
description BACKGROUND: Air pollution exposure during pregnancy has been associated with impaired fetal growth. However, few studies have measured fetal biometry longitudinally, remaining unclear as to whether there are windows of special vulnerability. OBJECTIVE: The aim was to investigate the impact of nitrogen dioxide (NO2) exposure on fetal and neonatal biometry in the Spanish INMA study. METHODS: Biparietal diameter (BPD), femur length (FL), abdominal circumference (AC), and estimated fetal weight (EFW) were evaluated for up to 2,478 fetuses in each trimester of pregnancy. Size at 12, 20, and 34 weeks of gestation and growth between these points, as well as anthropometry at birth, were assessed by SD scores derived using cohort-specific growth curves. Temporally adjusted land-use regression was used to estimate exposure to NO2 at home addresses for up to 2,415 fetuses. Associations were investigated by linear regression in each cohort and subsequent meta-analysis. RESULTS: A 10-μg/m3 increase in average exposure to NO2 during weeks 0-12 was associated with reduced growth at weeks 0-12 in AC (-2.1%; 95% CI: -3.7, -0.6) and EFW (-1.6%; 95% CI: -3.0, -0.3). The same exposure was inversely associated with reduced growth at weeks 20-34 in BPD (-2.6%; 95% CI: -3.9, -1.2), AC (-1.8%; 95% CI: -3.3, -0.2), and EFW (-2.1%; 95% CI: -3.7, -0.2). A less consistent pattern of association was observed for FL. The negative association of this exposure with BPD and EFW was significantly stronger in smoking versus nonsmoking mothers. CONCLUSIONS: Maternal exposure to NO2 in early pregnancy was associated with reduced fetal growth based on ultrasound measures of growth during pregnancy and measures of size at birth.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/25946
http://dx.doi.org/10.1289/ehp.1409423
url http://hdl.handle.net/10230/25946
http://dx.doi.org/10.1289/ehp.1409423
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Environmental Health Perspectives. 2016 Feb;124(2):235-42
info:eu-repo/grantAgreement/EC/FP7/282957
info:eu-repo/grantAgreement/EC/FP6/16320
dc.rights.none.fl_str_mv Reproduced with permission from Environmental Health perspectives
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reproduced with permission from Environmental Health perspectives
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Institute of Environmental Health Sciences (NIEHS)
publisher.none.fl_str_mv National Institute of Environmental Health Sciences (NIEHS)
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420422462701568
score 15,811543

Similares en LA Referencia