Comparative Assessment Of Hpv, Alcohol And Tobacco Etiological Fractions In Algerian Patients With Laryngeal Squamous Cell Carcinoma

Background: Despite the increasing incidence of laryngeal squamous cell carcinoma (LSCC) in Algeria, scarce information is available on the importance of the preventable etiological factors which may drive the disease. Remarkably, a significant number of cases occur in nonsmoker and nondrinker patie...

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Authors: Kariche, Nora, Torres Hortal, Montserrat, Benyahia, Samir, Alemany i Vilches, Laia, Moulai, Nabila, Clavero, Omar, Muñoz, Marleny, Ouahioune, Wahiba, Djennaoui, Djamel, Touil-Boukoffa, Chafia, Sanjosé Llongueras, Silvia de, Bourouba, Mehdi
Format: article
Status:Published version
Publication Date:2018
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/123989
Online Access:https://hdl.handle.net/2445/123989
Access Level:Open access
Keyword:Càncer de coll
Tabac
Consum d'alcohol
Neck cancer
Tobacco
Drinking of alcoholic beverages
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spelling Comparative Assessment Of Hpv, Alcohol And Tobacco Etiological Fractions In Algerian Patients With Laryngeal Squamous Cell CarcinomaKariche, NoraTorres Hortal, MontserratBenyahia, SamirAlemany i Vilches, LaiaMoulai, NabilaClavero, OmarMuñoz, MarlenyOuahioune, WahibaDjennaoui, DjamelTouil-Boukoffa, ChafiaSanjosé Llongueras, Silvia deBourouba, MehdiCàncer de collTabacConsum d'alcoholNeck cancerTobaccoDrinking of alcoholic beveragesBackground: Despite the increasing incidence of laryngeal squamous cell carcinoma (LSCC) in Algeria, scarce information is available on the importance of the preventable etiological factors which may drive the disease. Remarkably, a significant number of cases occur in nonsmoker and nondrinker patients; hence, suggesting that alternative risk factors, like Human papillomavirus (HPV), might be etiologically involved. To gain more insight on the risk factors associated with the disease in the country, we evaluated the etiological fraction of HPV in comparison to tobacco and alcohol intake in LSCC patients. Methods: To evaluate the etiopathologic fraction (EF) for HPV compared to history of tobacco and alcohol in LSCC, HPV DNA presence in 46 invasive and 3 non-invasive formalin-fixed paraffin-embedded laryngeal tumors was screened using the SPF10-DEIA-LiPA25 Assay. Demographic data and information related to exposure to the risk factors were gathered through interviewer-assisted questionnaires. Results: We observed that 40.8% of all LSCC cases were associated with smoking, 40.8% had combined tobacco and alcohol exposure history, and 14.3% did not show prior exposure to either risk factor. 1 out of 3 in-situ carcinoma cases was positive for HPV-6. HPV prevalence was null in the invasive tumors. HPV DNA was detected in 2.38% for all studied cases. 10.2% of LSCC patients did not associate with any of the studied risk factors. Conclusion: Here we show that HPV etiological fraction in LSCC Algerian patients is low and smoking and alcohol remain the principal etiopathologic risk for LSCC burden in Algeria.Biomed Central Ltd2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/123989Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1186/s13027-018-0181-xInfectious Agents And Cancer, 2018, Vol. 13:8https://doi.org/10.1186/s13027-018-0181-xcc-by (c) Kariche, Nora et al., 2018http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1239892026-05-27T06:46:51Z
dc.title.none.fl_str_mv Comparative Assessment Of Hpv, Alcohol And Tobacco Etiological Fractions In Algerian Patients With Laryngeal Squamous Cell Carcinoma
title Comparative Assessment Of Hpv, Alcohol And Tobacco Etiological Fractions In Algerian Patients With Laryngeal Squamous Cell Carcinoma
spellingShingle Comparative Assessment Of Hpv, Alcohol And Tobacco Etiological Fractions In Algerian Patients With Laryngeal Squamous Cell Carcinoma
Kariche, Nora
Càncer de coll
Tabac
Consum d'alcohol
Neck cancer
Tobacco
Drinking of alcoholic beverages
title_short Comparative Assessment Of Hpv, Alcohol And Tobacco Etiological Fractions In Algerian Patients With Laryngeal Squamous Cell Carcinoma
title_full Comparative Assessment Of Hpv, Alcohol And Tobacco Etiological Fractions In Algerian Patients With Laryngeal Squamous Cell Carcinoma
title_fullStr Comparative Assessment Of Hpv, Alcohol And Tobacco Etiological Fractions In Algerian Patients With Laryngeal Squamous Cell Carcinoma
title_full_unstemmed Comparative Assessment Of Hpv, Alcohol And Tobacco Etiological Fractions In Algerian Patients With Laryngeal Squamous Cell Carcinoma
title_sort Comparative Assessment Of Hpv, Alcohol And Tobacco Etiological Fractions In Algerian Patients With Laryngeal Squamous Cell Carcinoma
dc.creator.none.fl_str_mv Kariche, Nora
Torres Hortal, Montserrat
Benyahia, Samir
Alemany i Vilches, Laia
Moulai, Nabila
Clavero, Omar
Muñoz, Marleny
Ouahioune, Wahiba
Djennaoui, Djamel
Touil-Boukoffa, Chafia
Sanjosé Llongueras, Silvia de
Bourouba, Mehdi
author Kariche, Nora
author_facet Kariche, Nora
Torres Hortal, Montserrat
Benyahia, Samir
Alemany i Vilches, Laia
Moulai, Nabila
Clavero, Omar
Muñoz, Marleny
Ouahioune, Wahiba
Djennaoui, Djamel
Touil-Boukoffa, Chafia
Sanjosé Llongueras, Silvia de
Bourouba, Mehdi
author_role author
author2 Torres Hortal, Montserrat
Benyahia, Samir
Alemany i Vilches, Laia
Moulai, Nabila
Clavero, Omar
Muñoz, Marleny
Ouahioune, Wahiba
Djennaoui, Djamel
Touil-Boukoffa, Chafia
Sanjosé Llongueras, Silvia de
Bourouba, Mehdi
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer de coll
Tabac
Consum d'alcohol
Neck cancer
Tobacco
Drinking of alcoholic beverages
topic Càncer de coll
Tabac
Consum d'alcohol
Neck cancer
Tobacco
Drinking of alcoholic beverages
description Background: Despite the increasing incidence of laryngeal squamous cell carcinoma (LSCC) in Algeria, scarce information is available on the importance of the preventable etiological factors which may drive the disease. Remarkably, a significant number of cases occur in nonsmoker and nondrinker patients; hence, suggesting that alternative risk factors, like Human papillomavirus (HPV), might be etiologically involved. To gain more insight on the risk factors associated with the disease in the country, we evaluated the etiological fraction of HPV in comparison to tobacco and alcohol intake in LSCC patients. Methods: To evaluate the etiopathologic fraction (EF) for HPV compared to history of tobacco and alcohol in LSCC, HPV DNA presence in 46 invasive and 3 non-invasive formalin-fixed paraffin-embedded laryngeal tumors was screened using the SPF10-DEIA-LiPA25 Assay. Demographic data and information related to exposure to the risk factors were gathered through interviewer-assisted questionnaires. Results: We observed that 40.8% of all LSCC cases were associated with smoking, 40.8% had combined tobacco and alcohol exposure history, and 14.3% did not show prior exposure to either risk factor. 1 out of 3 in-situ carcinoma cases was positive for HPV-6. HPV prevalence was null in the invasive tumors. HPV DNA was detected in 2.38% for all studied cases. 10.2% of LSCC patients did not associate with any of the studied risk factors. Conclusion: Here we show that HPV etiological fraction in LSCC Algerian patients is low and smoking and alcohol remain the principal etiopathologic risk for LSCC burden in Algeria.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/123989
url https://hdl.handle.net/2445/123989
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/s13027-018-0181-x
Infectious Agents And Cancer, 2018, Vol. 13:8
https://doi.org/10.1186/s13027-018-0181-x
dc.rights.none.fl_str_mv cc-by (c) Kariche, Nora et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Kariche, Nora et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Biomed Central Ltd
publisher.none.fl_str_mv Biomed Central Ltd
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420421197070336
score 15.300719

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