Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin
[EN]Sexual dimorphism has been reported in many processes. However, sexual bias in favour of the use of males is very present in science. One of the main reasons is that the impact of hormones in diverse pathways and processes such as autophagy have not been properly addressed in vivo. The Harderian...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universidad de Salamanca (USAL) |
| Repositorio: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:gredos.usal.es:10366/161912 |
| Acceso en línea: | http://hdl.handle.net/10366/161912 |
| Access Level: | acceso abierto |
| Palabra clave: | Melatonin Autophagy Mouse Lipophagy Sexual cycle Mitophagy Harderian Gland Sexual Behavior, Animal Reproduction Rodentia 2407 Biología Celular 2401 Biología Animal (Zoología) 2411.16 Fisiología de la Reproducción glándula de Harder reproducción autofagia conducta sexual animal melatonina |
| id |
ES_d2f972f1a0d63a81298d0d4bae3fbbea |
|---|---|
| oai_identifier_str |
oai:gredos.usal.es:10366/161912 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatoninGarcía Macia, MarinaSantos Ledo, AdriánCaballero, BeatrizRubio-González, Adriande Luxán-Delgado, BeatrizPotes, YaizaRodríguez-González, Susana Mª.Boga, José AntonioCoto-Montes, AnaMelatoninAutophagyMouseLipophagySexual cycleMitophagyHarderian GlandMelatoninSexual Behavior, AnimalReproductionRodentiaAutophagy2407 Biología Celular2401 Biología Animal (Zoología)2411.16 Fisiología de la Reproducciónglándula de HarderreproducciónRodentiaautofagiaconducta sexual animalmelatonina[EN]Sexual dimorphism has been reported in many processes. However, sexual bias in favour of the use of males is very present in science. One of the main reasons is that the impact of hormones in diverse pathways and processes such as autophagy have not been properly addressed in vivo. The Harderian gland is a perfect model to study autophagic modulation as it exhibits important changes during the oestrous cycle. The aim of this study is to identify the main processes behind Harderian gland differences under oestrous cycle and their modulator. In the present study we show that redox-sensitive transcription factors have an essential role: NF-κB may activate SQSTM1/p62 in oestrus, promoting selective types of autophagy: mitophagy and lipophagy. Nrf2 activation in dioestrus, leads the retrieval phase and restoration of mitochondrial homeostasis. Melatonin’s receptors show higher expression in dioestrus, leading to decreases in pro-inflammatory mediators and enhanced Nrf2 expression. Consequently, autophagy is blocked, and porphyrin release is reduced. All these results point to melatonin as one of the main modulators of the changes in autophagy during the oestrous cycle.We are members of the INPROTEOLYS, SEBBM, SEFAGIA and INEUROPA network. We acknowledge Fibrosis and Bolaños´lab for their support during the manuscript revisions. This work was supported by FISS-18-PI17/02009, C0120R3166, C0245R4032 and BH182173. MG-M has a postdoctoral fellowship from the Instituto de Salud Carlos III (ISCIII), Ministerio de Ciencia, Innovación y Universidades. Financial support from the University of Oviedo is also acknowledged.202520252019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/161912reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésFISS-18-PI17/02009C0120R3166C0245R4032BH182173Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1619122026-06-07T06:28:51Z |
| dc.title.none.fl_str_mv |
Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin |
| title |
Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin |
| spellingShingle |
Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin García Macia, Marina Melatonin Autophagy Mouse Lipophagy Sexual cycle Mitophagy Harderian Gland Melatonin Sexual Behavior, Animal Reproduction Rodentia Autophagy 2407 Biología Celular 2401 Biología Animal (Zoología) 2411.16 Fisiología de la Reproducción glándula de Harder reproducción Rodentia autofagia conducta sexual animal melatonina |
| title_short |
Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin |
| title_full |
Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin |
| title_fullStr |
Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin |
| title_full_unstemmed |
Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin |
| title_sort |
Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin |
| dc.creator.none.fl_str_mv |
García Macia, Marina Santos Ledo, Adrián Caballero, Beatriz Rubio-González, Adrian de Luxán-Delgado, Beatriz Potes, Yaiza Rodríguez-González, Susana Mª. Boga, José Antonio Coto-Montes, Ana |
| author |
García Macia, Marina |
| author_facet |
García Macia, Marina Santos Ledo, Adrián Caballero, Beatriz Rubio-González, Adrian de Luxán-Delgado, Beatriz Potes, Yaiza Rodríguez-González, Susana Mª. Boga, José Antonio Coto-Montes, Ana |
| author_role |
author |
| author2 |
Santos Ledo, Adrián Caballero, Beatriz Rubio-González, Adrian de Luxán-Delgado, Beatriz Potes, Yaiza Rodríguez-González, Susana Mª. Boga, José Antonio Coto-Montes, Ana |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
Melatonin Autophagy Mouse Lipophagy Sexual cycle Mitophagy Harderian Gland Melatonin Sexual Behavior, Animal Reproduction Rodentia Autophagy 2407 Biología Celular 2401 Biología Animal (Zoología) 2411.16 Fisiología de la Reproducción glándula de Harder reproducción Rodentia autofagia conducta sexual animal melatonina |
| topic |
Melatonin Autophagy Mouse Lipophagy Sexual cycle Mitophagy Harderian Gland Melatonin Sexual Behavior, Animal Reproduction Rodentia Autophagy 2407 Biología Celular 2401 Biología Animal (Zoología) 2411.16 Fisiología de la Reproducción glándula de Harder reproducción Rodentia autofagia conducta sexual animal melatonina |
| description |
[EN]Sexual dimorphism has been reported in many processes. However, sexual bias in favour of the use of males is very present in science. One of the main reasons is that the impact of hormones in diverse pathways and processes such as autophagy have not been properly addressed in vivo. The Harderian gland is a perfect model to study autophagic modulation as it exhibits important changes during the oestrous cycle. The aim of this study is to identify the main processes behind Harderian gland differences under oestrous cycle and their modulator. In the present study we show that redox-sensitive transcription factors have an essential role: NF-κB may activate SQSTM1/p62 in oestrus, promoting selective types of autophagy: mitophagy and lipophagy. Nrf2 activation in dioestrus, leads the retrieval phase and restoration of mitochondrial homeostasis. Melatonin’s receptors show higher expression in dioestrus, leading to decreases in pro-inflammatory mediators and enhanced Nrf2 expression. Consequently, autophagy is blocked, and porphyrin release is reduced. All these results point to melatonin as one of the main modulators of the changes in autophagy during the oestrous cycle. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10366/161912 |
| url |
http://hdl.handle.net/10366/161912 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
FISS-18-PI17/02009 C0120R3166 C0245R4032 BH182173 |
| dc.rights.none.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.source.none.fl_str_mv |
reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca instname:Universidad de Salamanca (USAL) |
| instname_str |
Universidad de Salamanca (USAL) |
| reponame_str |
GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| collection |
GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869420420071948288 |
| score |
15,812429 |