Telomeres and telomerase in the clinical management of colorectal cancer

Colorectal cancer (CRC) is the third most common cancer worldwide. Our aim is to describe the state of the art about the role of telomeres and telomerase in the clinical management of CRC and its potential utility as prognostic and diagnostic biomarkers and targets of new treatments. Telomere length...

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Detalles Bibliográficos
Autores: Piñol-Felis, C., Viñas-Salas, J., Valls-Bautista, C., Fernández Marcelo, Tamara
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/128503
Acceso en línea:https://hdl.handle.net/20.500.14352/128503
Access Level:acceso abierto
Palabra clave:616-006.04-085
615.4
telomeres
telomerase
colorectal cancer
Oncología
Tecnología farmaceútica
32 Ciencias Médicas
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spelling Telomeres and telomerase in the clinical management of colorectal cancerPiñol-Felis, C.Viñas-Salas, J.Valls-Bautista, C.Fernández Marcelo, Tamara616-006.04-085615.4telomerestelomerasecolorectal cancerOncologíaTecnología farmaceútica32 Ciencias MédicasColorectal cancer (CRC) is the third most common cancer worldwide. Our aim is to describe the state of the art about the role of telomeres and telomerase in the clinical management of CRC and its potential utility as prognostic and diagnostic biomarkers and targets of new treatments. Telomere length could be a new diagnostic marker as an anomalous behavior is observed in peripheral blood cells when CRC patients and healthy people are compared. Moreover, telomeres and telomerase may be used as diagnostic markers considering that universal changes appear along the CRC process. Currently, new therapeutic cancer approaches are focused on inhibiting the maintenance of telomere length, choosing as targets telomerase -or its subunits- or the Shelterin complex. The goal of these therapies is the shortening of telomeres and the induction of cell senescence. Telomeres and telomerase emerge as useful molecular tools in the clinical management of CRC.SpringerUniversidad Complutense de Madrid20172017-01-0120172017-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/128503reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1285032026-06-02T12:44:21Z
dc.title.none.fl_str_mv Telomeres and telomerase in the clinical management of colorectal cancer
title Telomeres and telomerase in the clinical management of colorectal cancer
spellingShingle Telomeres and telomerase in the clinical management of colorectal cancer
Piñol-Felis, C.
616-006.04-085
615.4
telomeres
telomerase
colorectal cancer
Oncología
Tecnología farmaceútica
32 Ciencias Médicas
title_short Telomeres and telomerase in the clinical management of colorectal cancer
title_full Telomeres and telomerase in the clinical management of colorectal cancer
title_fullStr Telomeres and telomerase in the clinical management of colorectal cancer
title_full_unstemmed Telomeres and telomerase in the clinical management of colorectal cancer
title_sort Telomeres and telomerase in the clinical management of colorectal cancer
dc.creator.none.fl_str_mv Piñol-Felis, C.
Viñas-Salas, J.
Valls-Bautista, C.
Fernández Marcelo, Tamara
author Piñol-Felis, C.
author_facet Piñol-Felis, C.
Viñas-Salas, J.
Valls-Bautista, C.
Fernández Marcelo, Tamara
author_role author
author2 Viñas-Salas, J.
Valls-Bautista, C.
Fernández Marcelo, Tamara
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616-006.04-085
615.4
telomeres
telomerase
colorectal cancer
Oncología
Tecnología farmaceútica
32 Ciencias Médicas
topic 616-006.04-085
615.4
telomeres
telomerase
colorectal cancer
Oncología
Tecnología farmaceútica
32 Ciencias Médicas
description Colorectal cancer (CRC) is the third most common cancer worldwide. Our aim is to describe the state of the art about the role of telomeres and telomerase in the clinical management of CRC and its potential utility as prognostic and diagnostic biomarkers and targets of new treatments. Telomere length could be a new diagnostic marker as an anomalous behavior is observed in peripheral blood cells when CRC patients and healthy people are compared. Moreover, telomeres and telomerase may be used as diagnostic markers considering that universal changes appear along the CRC process. Currently, new therapeutic cancer approaches are focused on inhibiting the maintenance of telomere length, choosing as targets telomerase -or its subunits- or the Shelterin complex. The goal of these therapies is the shortening of telomeres and the induction of cell senescence. Telomeres and telomerase emerge as useful molecular tools in the clinical management of CRC.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01
2017
2017-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/128503
url https://hdl.handle.net/20.500.14352/128503
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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