Potential Adaptive Introgression From Dogs in Iberian Grey Wolves (Canis lupus)

Invading species along with increased anthropogenization may lead to hybridization events between wild species and closely related domesticates. As a consequence, wild species may carry introgressed alleles from domestic species, which is generally assumed to yield adverse effects in wild population...

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Detalles Bibliográficos
Autores: Sarabia, Carlos, Salado, Isabel, Fernández-Gil, Alberto, Holdt, Bridgett M. von, Hofreiter, Michael, Vilà, Carles, Leonard, Jennifer A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/399730
Acceso en línea:http://hdl.handle.net/10261/399730
https://api.elsevier.com/content/abstract/scopus_id/85214646991
Access Level:acceso abierto
Palabra clave:Canis lupus signatus
Introgression
Admixture
Behavioural genes
Hybridization
Immune system
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dc.title.none.fl_str_mv Potential Adaptive Introgression From Dogs in Iberian Grey Wolves (Canis lupus)
title Potential Adaptive Introgression From Dogs in Iberian Grey Wolves (Canis lupus)
spellingShingle Potential Adaptive Introgression From Dogs in Iberian Grey Wolves (Canis lupus)
Sarabia, Carlos
Canis lupus signatus
Introgression
Admixture
Behavioural genes
Hybridization
Immune system
title_short Potential Adaptive Introgression From Dogs in Iberian Grey Wolves (Canis lupus)
title_full Potential Adaptive Introgression From Dogs in Iberian Grey Wolves (Canis lupus)
title_fullStr Potential Adaptive Introgression From Dogs in Iberian Grey Wolves (Canis lupus)
title_full_unstemmed Potential Adaptive Introgression From Dogs in Iberian Grey Wolves (Canis lupus)
title_sort Potential Adaptive Introgression From Dogs in Iberian Grey Wolves (Canis lupus)
dc.creator.none.fl_str_mv Sarabia, Carlos
Salado, Isabel
Fernández-Gil, Alberto
Holdt, Bridgett M. von
Hofreiter, Michael
Vilà, Carles
Leonard, Jennifer A.
author Sarabia, Carlos
author_facet Sarabia, Carlos
Salado, Isabel
Fernández-Gil, Alberto
Holdt, Bridgett M. von
Hofreiter, Michael
Vilà, Carles
Leonard, Jennifer A.
author_role author
author2 Salado, Isabel
Fernández-Gil, Alberto
Holdt, Bridgett M. von
Hofreiter, Michael
Vilà, Carles
Leonard, Jennifer A.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Junta de Andalucía
Ministerio de Universidades (España)
Ford Motor Company Fund and Community Services
BiodivERsA
European Commission
Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
CSIC - Unidad de Recursos de Información Científica para la Investigación (URICI)
Sarabia, Carlos [0000-0002-6980-3480]
Salado, Isabel [0000-0002-8861-2436]
Fernández-Gil, Alberto [0000-0001-9125-955X]
Holdt, Bridgett M. von [0000-0001-6908-1687]
Hofreiter, Michael [0000-0003-0441-4705]
Vilà, Carles [0000-0002-4206-5246]
Leonard, Jennifer A. [0000-0003-0291-7819]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Canis lupus signatus
Introgression
Admixture
Behavioural genes
Hybridization
Immune system
topic Canis lupus signatus
Introgression
Admixture
Behavioural genes
Hybridization
Immune system
description Invading species along with increased anthropogenization may lead to hybridization events between wild species and closely related domesticates. As a consequence, wild species may carry introgressed alleles from domestic species, which is generally assumed to yield adverse effects in wild populations. The opposite evolutionary consequence, adaptive introgression, where introgressed genes are positively selected in the wild species, is possible but has rarely been documented. Grey wolves (Canis lupus) are widely distributed across the Holarctic and frequently coexist with their close relative, the domestic dog (C. familiaris). Despite ample opportunity, hybridization rarely occurs in most populations. Here we studied the geographically isolated grey wolves of the Iberian Peninsula, who have coexisted with a large population of loosely controlled dogs for thousands of years in a human-modified landscape. We assessed the extent and impact of dog introgression on the current Iberian grey wolf population by analysing 150 whole genomes of Iberian and other Eurasian grey wolves as well as dogs originating from across Europe and western Siberia. We identified almost no recent introgression and a small (< 5%) overall ancient dog ancestry. Using a combination of single scan statistics and ancestry enrichment estimates, we identified positive selection on six genes (DAPP1, NSMCE4A, MPPED2, PCDH9, MBTPS1, and CDH13) for which wild Iberian wolves carry alleles introgressed from dogs. The genes with introgressed and positively selected alleles include functions in immune response and brain functions, which may explain some of the unique behavioural phenotypes in Iberian wolves such as their reduced dispersal compared to other wolf populations.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/399730
https://api.elsevier.com/content/abstract/scopus_id/85214646991
url http://hdl.handle.net/10261/399730
https://api.elsevier.com/content/abstract/scopus_id/85214646991
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PCI2022-135098-2
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1111/mec.17639
Code for bioinformatic analyses is available at https://github.com/cdomsar/ibgw-adaptive-introgression.
https://doi.org/10.1111/mec.17639
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Potential Adaptive Introgression From Dogs in Iberian Grey Wolves (Canis lupus)Sarabia, CarlosSalado, IsabelFernández-Gil, AlbertoHoldt, Bridgett M. vonHofreiter, MichaelVilà, CarlesLeonard, Jennifer A.Canis lupus signatusIntrogressionAdmixtureBehavioural genesHybridizationImmune systemInvading species along with increased anthropogenization may lead to hybridization events between wild species and closely related domesticates. As a consequence, wild species may carry introgressed alleles from domestic species, which is generally assumed to yield adverse effects in wild populations. The opposite evolutionary consequence, adaptive introgression, where introgressed genes are positively selected in the wild species, is possible but has rarely been documented. Grey wolves (Canis lupus) are widely distributed across the Holarctic and frequently coexist with their close relative, the domestic dog (C. familiaris). Despite ample opportunity, hybridization rarely occurs in most populations. Here we studied the geographically isolated grey wolves of the Iberian Peninsula, who have coexisted with a large population of loosely controlled dogs for thousands of years in a human-modified landscape. We assessed the extent and impact of dog introgression on the current Iberian grey wolf population by analysing 150 whole genomes of Iberian and other Eurasian grey wolves as well as dogs originating from across Europe and western Siberia. We identified almost no recent introgression and a small (< 5%) overall ancient dog ancestry. Using a combination of single scan statistics and ancestry enrichment estimates, we identified positive selection on six genes (DAPP1, NSMCE4A, MPPED2, PCDH9, MBTPS1, and CDH13) for which wild Iberian wolves carry alleles introgressed from dogs. The genes with introgressed and positively selected alleles include functions in immune response and brain functions, which may explain some of the unique behavioural phenotypes in Iberian wolves such as their reduced dispersal compared to other wolf populations.This research was funded by Junta de Andalucía (‘Proyectos de generación de conocimiento’ P18-FR-5099 to J.A.L and C.V.); I.S. received a PhDfellowship, ‘Ayudas para la formación de profesorado Universitario (FPU)’ from the Spanish Ministry of Universities (FPU17/02584) and a research contract by ‘Asociación Apadrina La Ciencia’ co-funded by the Ford Motor Company Fund. This research was also partly funded by the WOLFNESS project within the Biodiversa+ program, the European Biodiversity Partnership under the 2021–2022 BiodivProtect joint call for research proposals, co-funded by the European Commission (GA N101052342) and the Spanish Ministry of Science and Innovation (PCI2022-135098-2). We acknowledge support of the publica-tion fee by the CSIC Open Access Publication Support Initiative through its Unit of Information Resources for Research (URICi).Peer reviewedJohn Wiley & SonsJunta de AndalucíaMinisterio de Universidades (España)Ford Motor Company Fund and Community ServicesBiodivERsAEuropean CommissionMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)CSIC - Unidad de Recursos de Información Científica para la Investigación (URICI)Sarabia, Carlos [0000-0002-6980-3480]Salado, Isabel [0000-0002-8861-2436]Fernández-Gil, Alberto [0000-0001-9125-955X]Holdt, Bridgett M. von [0000-0001-6908-1687]Hofreiter, Michael [0000-0003-0441-4705]Vilà, Carles [0000-0002-4206-5246]Leonard, Jennifer A. [0000-0003-0291-7819]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/399730https://api.elsevier.com/content/abstract/scopus_id/85214646991reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PCI2022-135098-2The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1111/mec.17639Code for bioinformatic analyses is available at https://github.com/cdomsar/ibgw-adaptive-introgression.https://doi.org/10.1111/mec.17639Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3997302026-05-22T06:33:51Z
score 15.81155

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