Efficacy assessment of liposome crosslinked hyaluronic acid and standard hyaluronic acid eye drops for dry eye disease management: a comparative study employing the ocular surface analyzer and subjective questionnaires

Introduction: Dry eye disease (DED) is a prevalent condition causing ocular discomfort and visual disturbances, often managed with artificial tears. This study aimed to assess and compare the efficacy of eye drops containing Crosslinked Hyaluronic Acid (CHA) with liposomes and crocin and standard Hy...

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Authors: Sánchez González, José María, Hita Cantalejo, María Concepción de, González Rodríguez, María Luisa, Fernández Trueba-Fagúndez, Ana, Ballesteros Sánchez, Antonio, Martínez Pérez, Clara, Caro Díaz, Romina, Montiel Guzmán, Carla, González Oyarce, María Fernanda, Sánchez González, María del Carmen
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Universidad de Sevilla (US)
Repository:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/166836
Online Access:https://hdl.handle.net/11441/166836
https://doi.org/10.3389/fmed.2024.1264695
Access Level:Open access
Keyword:Crosslinked hyaluronic acid
Dry eye disease
Hyaluronic acid
Lipid layer
Liposome
Ocular surface
Tear film stability
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spelling Efficacy assessment of liposome crosslinked hyaluronic acid and standard hyaluronic acid eye drops for dry eye disease management: a comparative study employing the ocular surface analyzer and subjective questionnairesSánchez González, José MaríaHita Cantalejo, María Concepción deGonzález Rodríguez, María LuisaFernández Trueba-Fagúndez, AnaBallesteros Sánchez, AntonioMartínez Pérez, ClaraCaro Díaz, RominaMontiel Guzmán, CarlaGonzález Oyarce, María FernandaSánchez González, María del CarmenCrosslinked hyaluronic acidDry eye diseaseHyaluronic acidLipid layerLiposomeOcular surfaceTear film stabilityIntroduction: Dry eye disease (DED) is a prevalent condition causing ocular discomfort and visual disturbances, often managed with artificial tears. This study aimed to assess and compare the efficacy of eye drops containing Crosslinked Hyaluronic Acid (CHA) with liposomes and crocin and standard Hyaluronic Acid (HA) for DED management. Methods: A single-blind, longitudinal study was conducted on 24 participants (48 eyes), randomized to receive one of the two treatments. Ocular health measures, including the ocular surface disease index (OSDI) and the standard patient evaluation of eye dryness (SPEED) scores, were assessed at baseline and 6 weeks post-treatment using the Ocular Surface Analyzer. Results: CHA achieved a lipid layer thickness increase of 1.29 ± 1.08 Guillon pattern degree (p < 0.01), FNIBUT increase 0.64 ± 0.77 s (p < 0.01), MNIBUT increase1.28 ± 4.74 s (p = 0.19), OSDI decrease 11.72 ± 6.73 score points (p < 0.01) and SPEED decrease 1.16 ± 5.05 score points (p = 0.27). Significant reductions in the OSDI and SPEED scores post-treatment were observed with both treatments, indicating their effectiveness. Conclusion: CHA with liposomes exhibits superior efficacy compared to standard HA eye drops in the management of DED. These findings highlight the potential for personalized treatment strategies incorporating CHA, indicating a more effective approach to DED management. However, further research is required to validate these results and investigate the long-term effects, which may pave the way for a data-driven and optimized approach to managing DED.Frontiers Media S.A.Física de la Materia CondensadaFarmacia y Tecnología Farmacéutica2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/166836https://doi.org/10.3389/fmed.2024.1264695reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésFrontiers in Medicine, 11, 1264695.https://doi.org/10.3389/fmed.2024.1264695info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1668362026-06-17T12:51:07Z
dc.title.none.fl_str_mv Efficacy assessment of liposome crosslinked hyaluronic acid and standard hyaluronic acid eye drops for dry eye disease management: a comparative study employing the ocular surface analyzer and subjective questionnaires
title Efficacy assessment of liposome crosslinked hyaluronic acid and standard hyaluronic acid eye drops for dry eye disease management: a comparative study employing the ocular surface analyzer and subjective questionnaires
spellingShingle Efficacy assessment of liposome crosslinked hyaluronic acid and standard hyaluronic acid eye drops for dry eye disease management: a comparative study employing the ocular surface analyzer and subjective questionnaires
Sánchez González, José María
Crosslinked hyaluronic acid
Dry eye disease
Hyaluronic acid
Lipid layer
Liposome
Ocular surface
Tear film stability
title_short Efficacy assessment of liposome crosslinked hyaluronic acid and standard hyaluronic acid eye drops for dry eye disease management: a comparative study employing the ocular surface analyzer and subjective questionnaires
title_full Efficacy assessment of liposome crosslinked hyaluronic acid and standard hyaluronic acid eye drops for dry eye disease management: a comparative study employing the ocular surface analyzer and subjective questionnaires
title_fullStr Efficacy assessment of liposome crosslinked hyaluronic acid and standard hyaluronic acid eye drops for dry eye disease management: a comparative study employing the ocular surface analyzer and subjective questionnaires
title_full_unstemmed Efficacy assessment of liposome crosslinked hyaluronic acid and standard hyaluronic acid eye drops for dry eye disease management: a comparative study employing the ocular surface analyzer and subjective questionnaires
title_sort Efficacy assessment of liposome crosslinked hyaluronic acid and standard hyaluronic acid eye drops for dry eye disease management: a comparative study employing the ocular surface analyzer and subjective questionnaires
dc.creator.none.fl_str_mv Sánchez González, José María
Hita Cantalejo, María Concepción de
González Rodríguez, María Luisa
Fernández Trueba-Fagúndez, Ana
Ballesteros Sánchez, Antonio
Martínez Pérez, Clara
Caro Díaz, Romina
Montiel Guzmán, Carla
González Oyarce, María Fernanda
Sánchez González, María del Carmen
author Sánchez González, José María
author_facet Sánchez González, José María
Hita Cantalejo, María Concepción de
González Rodríguez, María Luisa
Fernández Trueba-Fagúndez, Ana
Ballesteros Sánchez, Antonio
Martínez Pérez, Clara
Caro Díaz, Romina
Montiel Guzmán, Carla
González Oyarce, María Fernanda
Sánchez González, María del Carmen
author_role author
author2 Hita Cantalejo, María Concepción de
González Rodríguez, María Luisa
Fernández Trueba-Fagúndez, Ana
Ballesteros Sánchez, Antonio
Martínez Pérez, Clara
Caro Díaz, Romina
Montiel Guzmán, Carla
González Oyarce, María Fernanda
Sánchez González, María del Carmen
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Física de la Materia Condensada
Farmacia y Tecnología Farmacéutica
dc.subject.none.fl_str_mv Crosslinked hyaluronic acid
Dry eye disease
Hyaluronic acid
Lipid layer
Liposome
Ocular surface
Tear film stability
topic Crosslinked hyaluronic acid
Dry eye disease
Hyaluronic acid
Lipid layer
Liposome
Ocular surface
Tear film stability
description Introduction: Dry eye disease (DED) is a prevalent condition causing ocular discomfort and visual disturbances, often managed with artificial tears. This study aimed to assess and compare the efficacy of eye drops containing Crosslinked Hyaluronic Acid (CHA) with liposomes and crocin and standard Hyaluronic Acid (HA) for DED management. Methods: A single-blind, longitudinal study was conducted on 24 participants (48 eyes), randomized to receive one of the two treatments. Ocular health measures, including the ocular surface disease index (OSDI) and the standard patient evaluation of eye dryness (SPEED) scores, were assessed at baseline and 6 weeks post-treatment using the Ocular Surface Analyzer. Results: CHA achieved a lipid layer thickness increase of 1.29 ± 1.08 Guillon pattern degree (p < 0.01), FNIBUT increase 0.64 ± 0.77 s (p < 0.01), MNIBUT increase1.28 ± 4.74 s (p = 0.19), OSDI decrease 11.72 ± 6.73 score points (p < 0.01) and SPEED decrease 1.16 ± 5.05 score points (p = 0.27). Significant reductions in the OSDI and SPEED scores post-treatment were observed with both treatments, indicating their effectiveness. Conclusion: CHA with liposomes exhibits superior efficacy compared to standard HA eye drops in the management of DED. These findings highlight the potential for personalized treatment strategies incorporating CHA, indicating a more effective approach to DED management. However, further research is required to validate these results and investigate the long-term effects, which may pave the way for a data-driven and optimized approach to managing DED.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/166836
https://doi.org/10.3389/fmed.2024.1264695
url https://hdl.handle.net/11441/166836
https://doi.org/10.3389/fmed.2024.1264695
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Medicine, 11, 1264695.
https://doi.org/10.3389/fmed.2024.1264695
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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