Structural and molecular analysis of elbow flexor muscles in modern humans and common chimpanzees

In the present study we calculated the muscle fascicle length (MFL) and the physiological cross-sectional area (PCSA) in the elbow flexor muscles of five Homo sapiens and five Pan troglodytes. We also assessed the expression of the myosin heavy chain (MyHC) isoforms with real-time quantitative polym...

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Authors: de Diego, Marina, Casado, Aroa, Gomez Martinez, Monica, Martín, Joshua, Pastor, Juan Francisco, Potau Ginés, Josep Maria
Format: article
Status:Versión aceptada para publicación
Publication Date:2020
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/225285
Online Access:https://hdl.handle.net/2445/225285
Access Level:Open access
Keyword:Músculs
Éssers humans
Ximpanzés
Muscles
Human beings
Chimpanzees
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spelling Structural and molecular analysis of elbow flexor muscles in modern humans and common chimpanzeesde Diego, MarinaCasado, AroaGomez Martinez, MonicaMartín, JoshuaPastor, Juan FranciscoPotau Ginés, Josep MariaMúsculsÉssers humansXimpanzésMusclesHuman beingsChimpanzeesIn the present study we calculated the muscle fascicle length (MFL) and the physiological cross-sectional area (PCSA) in the elbow flexor muscles of five Homo sapiens and five Pan troglodytes. We also assessed the expression of the myosin heavy chain (MyHC) isoforms with real-time quantitative polymerase chain reaction in the same muscles and, finally, we analyzed the muscle insertion sites in the proximal epiphyses of the ulna and the radius with 3D geometric morphometrics. Our main objective is to identify quantitative differences in the elbow flexor muscles of Homo sapiens and Pan troglodytes in terms of muscle architecture, expression of MyHC isoforms, and bone insertion sites and to explore the association of these differences with the types of locomotion developed by these two species of hominoid primates. We observed that the elbow flexor muscles had a greater PCSA and a higher expression of the fast MyHC-II isoforms in Pan troglodytes, while they had a greater MFL and a higher expression of the slow MyHC-I isoform in Homo sapiens. The insertion site of the brachialis was larger in Pan troglodytes, while that of the biceps brachii was larger in Homo sapiens. Our findings may be related to the greater capacity of force generation in the elbow flexor muscles of Pan troglodytes, as an adaptation to vertical climbing, and to the greater contraction speed and resistance to fatigue of the muscles in Homo sapiens, as an adaptation to the manipulative function of the upper extremities.Springer Verlag2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/225285Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a:Zoomorphology, 2020, vol. 139, p. 277-290(c) Springer Verlag, 2020info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2252852026-05-27T06:46:51Z
dc.title.none.fl_str_mv Structural and molecular analysis of elbow flexor muscles in modern humans and common chimpanzees
title Structural and molecular analysis of elbow flexor muscles in modern humans and common chimpanzees
spellingShingle Structural and molecular analysis of elbow flexor muscles in modern humans and common chimpanzees
de Diego, Marina
Músculs
Éssers humans
Ximpanzés
Muscles
Human beings
Chimpanzees
title_short Structural and molecular analysis of elbow flexor muscles in modern humans and common chimpanzees
title_full Structural and molecular analysis of elbow flexor muscles in modern humans and common chimpanzees
title_fullStr Structural and molecular analysis of elbow flexor muscles in modern humans and common chimpanzees
title_full_unstemmed Structural and molecular analysis of elbow flexor muscles in modern humans and common chimpanzees
title_sort Structural and molecular analysis of elbow flexor muscles in modern humans and common chimpanzees
dc.creator.none.fl_str_mv de Diego, Marina
Casado, Aroa
Gomez Martinez, Monica
Martín, Joshua
Pastor, Juan Francisco
Potau Ginés, Josep Maria
author de Diego, Marina
author_facet de Diego, Marina
Casado, Aroa
Gomez Martinez, Monica
Martín, Joshua
Pastor, Juan Francisco
Potau Ginés, Josep Maria
author_role author
author2 Casado, Aroa
Gomez Martinez, Monica
Martín, Joshua
Pastor, Juan Francisco
Potau Ginés, Josep Maria
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Músculs
Éssers humans
Ximpanzés
Muscles
Human beings
Chimpanzees
topic Músculs
Éssers humans
Ximpanzés
Muscles
Human beings
Chimpanzees
description In the present study we calculated the muscle fascicle length (MFL) and the physiological cross-sectional area (PCSA) in the elbow flexor muscles of five Homo sapiens and five Pan troglodytes. We also assessed the expression of the myosin heavy chain (MyHC) isoforms with real-time quantitative polymerase chain reaction in the same muscles and, finally, we analyzed the muscle insertion sites in the proximal epiphyses of the ulna and the radius with 3D geometric morphometrics. Our main objective is to identify quantitative differences in the elbow flexor muscles of Homo sapiens and Pan troglodytes in terms of muscle architecture, expression of MyHC isoforms, and bone insertion sites and to explore the association of these differences with the types of locomotion developed by these two species of hominoid primates. We observed that the elbow flexor muscles had a greater PCSA and a higher expression of the fast MyHC-II isoforms in Pan troglodytes, while they had a greater MFL and a higher expression of the slow MyHC-I isoform in Homo sapiens. The insertion site of the brachialis was larger in Pan troglodytes, while that of the biceps brachii was larger in Homo sapiens. Our findings may be related to the greater capacity of force generation in the elbow flexor muscles of Pan troglodytes, as an adaptation to vertical climbing, and to the greater contraction speed and resistance to fatigue of the muscles in Homo sapiens, as an adaptation to the manipulative function of the upper extremities.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/225285
url https://hdl.handle.net/2445/225285
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a:
Zoomorphology, 2020, vol. 139, p. 277-290
dc.rights.none.fl_str_mv (c) Springer Verlag, 2020
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Springer Verlag, 2020
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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