The multifaceted role of cathepsins in liver disease

Proteases are the most abundant enzyme gene family in vertebrates and they execute essential functions in all living organisms. Their main role is to hydrolase the peptide bond within proteins, a process also called proteolysis. Contrary to the conventional paradigm, proteases are not only random ca...

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Detalles Bibliográficos
Autores: Ruiz-Blázquez, Paloma, Pistorio, Valeria, Fernández-Fernández, María, Moles, Anna
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/260411
Acceso en línea:http://hdl.handle.net/10261/260411
Access Level:acceso abierto
Palabra clave:Cathepsin
Protease
Lysosome
Liver fibrosis
NAFLD
Hepatocellular carcinoma
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spelling The multifaceted role of cathepsins in liver diseaseRuiz-Blázquez, PalomaPistorio, ValeriaFernández-Fernández, MaríaMoles, AnnaCathepsinProteaseLysosomeLiver fibrosisNAFLDHepatocellular carcinomaProteases are the most abundant enzyme gene family in vertebrates and they execute essential functions in all living organisms. Their main role is to hydrolase the peptide bond within proteins, a process also called proteolysis. Contrary to the conventional paradigm, proteases are not only random catalytic devices, but can perform highly selective and targeted cleavage of specific substrates, finely modulating multiple essential cellular processes. Lysosomal protease cathepsins comprise 3 families of proteases that preferentially act within acidic cellular compartments, but they can also be found in other cellular locations. They can operate alone or as part of signalling cascades and regulatory circuits, playing important roles in apoptosis, extracellular matrix remodelling, hepatic stellate cell activation, autophagy and metastasis, contributing to the initiation, development and progression of liver disease. In this review, we comprehensively summarise current knowledge on the role of lysosomal cathepsins in liver disease, with a particular emphasis on liver fibrosis, non-alcoholic fatty liver disease and hepatocellular carcinoma.AM’s research was supported by a “Research Challenges" R+D+i Project (RTI2018-097475-A-100) and a Ramon y Cajal contract (RYC-2016-19731) awarded by FEDER/Ministerio de Ciencia e Innovación - Agencia Estatal de Investigación. PRB is supported by a FPU PhD studentship (FPU19/05357) funded by Ministerio de Ciencia, Innovación y Universidades. VP held a PhD studentship funded by University of Naples Federico II. MFF salary was supported by JAE Intro fellowship (JAEINT_20_02409) from the Spanish National Research Council (CSIC) and FI AGAUR (2021 FI_B 00249).Elsevier BVMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Ministerio de Economía y Competitividad (España)European CommissionUniversità degli Studi di Napoli Federico IIConsejo Superior de Investigaciones Científicas (España)Generalitat de CatalunyaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/260411reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097475-A-I00info:eu-repo/grantAgreement/MINECO//RYC-2016-19731http://dx.doi.org/10.1016/j.jhep.2021.06.031Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2604112026-05-22T06:33:51Z
dc.title.none.fl_str_mv The multifaceted role of cathepsins in liver disease
title The multifaceted role of cathepsins in liver disease
spellingShingle The multifaceted role of cathepsins in liver disease
Ruiz-Blázquez, Paloma
Cathepsin
Protease
Lysosome
Liver fibrosis
NAFLD
Hepatocellular carcinoma
title_short The multifaceted role of cathepsins in liver disease
title_full The multifaceted role of cathepsins in liver disease
title_fullStr The multifaceted role of cathepsins in liver disease
title_full_unstemmed The multifaceted role of cathepsins in liver disease
title_sort The multifaceted role of cathepsins in liver disease
dc.creator.none.fl_str_mv Ruiz-Blázquez, Paloma
Pistorio, Valeria
Fernández-Fernández, María
Moles, Anna
author Ruiz-Blázquez, Paloma
author_facet Ruiz-Blázquez, Paloma
Pistorio, Valeria
Fernández-Fernández, María
Moles, Anna
author_role author
author2 Pistorio, Valeria
Fernández-Fernández, María
Moles, Anna
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Ministerio de Economía y Competitividad (España)
European Commission
Università degli Studi di Napoli Federico II
Consejo Superior de Investigaciones Científicas (España)
Generalitat de Catalunya
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cathepsin
Protease
Lysosome
Liver fibrosis
NAFLD
Hepatocellular carcinoma
topic Cathepsin
Protease
Lysosome
Liver fibrosis
NAFLD
Hepatocellular carcinoma
description Proteases are the most abundant enzyme gene family in vertebrates and they execute essential functions in all living organisms. Their main role is to hydrolase the peptide bond within proteins, a process also called proteolysis. Contrary to the conventional paradigm, proteases are not only random catalytic devices, but can perform highly selective and targeted cleavage of specific substrates, finely modulating multiple essential cellular processes. Lysosomal protease cathepsins comprise 3 families of proteases that preferentially act within acidic cellular compartments, but they can also be found in other cellular locations. They can operate alone or as part of signalling cascades and regulatory circuits, playing important roles in apoptosis, extracellular matrix remodelling, hepatic stellate cell activation, autophagy and metastasis, contributing to the initiation, development and progression of liver disease. In this review, we comprehensively summarise current knowledge on the role of lysosomal cathepsins in liver disease, with a particular emphasis on liver fibrosis, non-alcoholic fatty liver disease and hepatocellular carcinoma.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/260411
url http://hdl.handle.net/10261/260411
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097475-A-I00
info:eu-repo/grantAgreement/MINECO//RYC-2016-19731
http://dx.doi.org/10.1016/j.jhep.2021.06.031
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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