Biocompatibility and bone regeneration with elastin-like recombinamer-based catalyst-free click gels
[EN]Large bone defects are a significant health problem today with various origins, including extensive trauma, tumours, or congenital musculoskeletal disorders. Tissue engineering, and in particular bone tissue engineering, aims to respond to this demand. As such, we propose a specific model based...
| Autores: | , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Universidad de Salamanca (USAL) |
| Repositorio: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:gredos.usal.es:10366/169465 |
| Acesso em linha: | http://hdl.handle.net/10366/169465 |
| Access Level: | acceso abierto |
| Palavra-chave: | Bone Elastin Scaffold Tissue engineering Hydrogels Tissue Engineering Animals Tissue Scaffolds Rabbits Bone Regeneration Click Chemistry Biocompatible Materials regeneración ósea materiales biocompatibles animales armazones tisulares química clic conejos ingeniería tisular elastina hidrogeles |
| Resumo: | [EN]Large bone defects are a significant health problem today with various origins, including extensive trauma, tumours, or congenital musculoskeletal disorders. Tissue engineering, and in particular bone tissue engineering, aims to respond to this demand. As such, we propose a specific model based on Elastin-Like Recombinamers-based click-chemistry hydrogels given their high biocompatibility and their potent on bone regeneration effect conferred by different bioactive sequences. In this work we demonstrate, using biochemistry, histology, histomorphometry and imaging techniques, the biocompatibility of our matrix and its potent effect on bone regeneration in a model of bone parietal lesion in female New Zealand rabbits. |
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