Dysmetabolic iron overload and cardiometabolic diseases. Cause-effect relationship or indirect association?

The prevalence of cardiometabolic diseases is increasing all over the world. Insulin resistance has been proposed as one major factor of the Metabolic syndrome (MetS) that ultimately leads to type 2 Diabetes Mellitus (T2DM). The relationship between iron status and MetS has been scarcely described....

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Detalles Bibliográficos
Autores: Vaquero, M. Pilar, Sánchez-Muniz, F. J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/241447
Acceso en línea:http://hdl.handle.net/10261/241447
Access Level:acceso abierto
Palabra clave:Cardiovascular diseases
Ferritin
Hepcidin
Insulin resistance
Iron overload
Metabolic syndrome
Transferrin
Type 2 diabetes mellitus
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spelling Dysmetabolic iron overload and cardiometabolic diseases. Cause-effect relationship or indirect association?Vaquero, M. PilarSánchez-Muniz, F. J.Cardiovascular diseasesFerritinHepcidinInsulin resistanceIron overloadMetabolic syndromeTransferrinType 2 diabetes mellitusThe prevalence of cardiometabolic diseases is increasing all over the world. Insulin resistance has been proposed as one major factor of the Metabolic syndrome (MetS) that ultimately leads to type 2 Diabetes Mellitus (T2DM). The relationship between iron status and MetS has been scarcely described. This mini-review presents on one hand the existing knowledge on the effects of excess body iron (iron overload) on insulin resistance and on the other the link between hyperglycemia and alterations in iron metabolism. When the binding capacity of serum transferrin exceeds normal levels, free-iron induces the formation of reactive oxygen species (ROS) which may increase oxidative stress and cause tissue damage. In addition, ROS have been linked to insulin resistance, reduction in adiponectin release, and non-alcoholic fatty liver, among others. It is also discussed that as a consequence of glucose excess, transferrin, as other proteins, becomes glycated decreasing its iron binding capacity resulting in elevated free-iron levels and the consequent deleterious effects. As in both, T2DM and hemochromatosis patients, a significant high ferritin-dyslipemia relationship has been reported, present review hypothesizes that iron stored as “ferritin” partially escapes to plasma contributing to the vicious circle. Increases in liver free fatty acids availability and gluconeogenesis aggravate insulin resistance, giving rise to adyslipemic profile. Nonetheless, several points and action mechanisms are still poorly understood and require more studies to elucidate the role of iron in the etiology of cardiometabolic diseases. Finally, it is suggested that subjects predisposed to cardiometabolic diseases and/or to accumulate iron should limit the prolonged consumption of iron supplements or iron fortified foods. Strategies to decrease the bioavailability of iron in such vulnerable population groups, such as recommending high vegetable diets, deserve future investigation.Study partially granted by project AGL 2014-53207-C2-2R.Peer reviewedJuniper PublishersMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/241447reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-53207-C2-2Rhttps://doi.org/10.19080/CRDOJ.2018.08.555727Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2414472026-05-22T06:33:51Z
dc.title.none.fl_str_mv Dysmetabolic iron overload and cardiometabolic diseases. Cause-effect relationship or indirect association?
title Dysmetabolic iron overload and cardiometabolic diseases. Cause-effect relationship or indirect association?
spellingShingle Dysmetabolic iron overload and cardiometabolic diseases. Cause-effect relationship or indirect association?
Vaquero, M. Pilar
Cardiovascular diseases
Ferritin
Hepcidin
Insulin resistance
Iron overload
Metabolic syndrome
Transferrin
Type 2 diabetes mellitus
title_short Dysmetabolic iron overload and cardiometabolic diseases. Cause-effect relationship or indirect association?
title_full Dysmetabolic iron overload and cardiometabolic diseases. Cause-effect relationship or indirect association?
title_fullStr Dysmetabolic iron overload and cardiometabolic diseases. Cause-effect relationship or indirect association?
title_full_unstemmed Dysmetabolic iron overload and cardiometabolic diseases. Cause-effect relationship or indirect association?
title_sort Dysmetabolic iron overload and cardiometabolic diseases. Cause-effect relationship or indirect association?
dc.creator.none.fl_str_mv Vaquero, M. Pilar
Sánchez-Muniz, F. J.
author Vaquero, M. Pilar
author_facet Vaquero, M. Pilar
Sánchez-Muniz, F. J.
author_role author
author2 Sánchez-Muniz, F. J.
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cardiovascular diseases
Ferritin
Hepcidin
Insulin resistance
Iron overload
Metabolic syndrome
Transferrin
Type 2 diabetes mellitus
topic Cardiovascular diseases
Ferritin
Hepcidin
Insulin resistance
Iron overload
Metabolic syndrome
Transferrin
Type 2 diabetes mellitus
description The prevalence of cardiometabolic diseases is increasing all over the world. Insulin resistance has been proposed as one major factor of the Metabolic syndrome (MetS) that ultimately leads to type 2 Diabetes Mellitus (T2DM). The relationship between iron status and MetS has been scarcely described. This mini-review presents on one hand the existing knowledge on the effects of excess body iron (iron overload) on insulin resistance and on the other the link between hyperglycemia and alterations in iron metabolism. When the binding capacity of serum transferrin exceeds normal levels, free-iron induces the formation of reactive oxygen species (ROS) which may increase oxidative stress and cause tissue damage. In addition, ROS have been linked to insulin resistance, reduction in adiponectin release, and non-alcoholic fatty liver, among others. It is also discussed that as a consequence of glucose excess, transferrin, as other proteins, becomes glycated decreasing its iron binding capacity resulting in elevated free-iron levels and the consequent deleterious effects. As in both, T2DM and hemochromatosis patients, a significant high ferritin-dyslipemia relationship has been reported, present review hypothesizes that iron stored as “ferritin” partially escapes to plasma contributing to the vicious circle. Increases in liver free fatty acids availability and gluconeogenesis aggravate insulin resistance, giving rise to adyslipemic profile. Nonetheless, several points and action mechanisms are still poorly understood and require more studies to elucidate the role of iron in the etiology of cardiometabolic diseases. Finally, it is suggested that subjects predisposed to cardiometabolic diseases and/or to accumulate iron should limit the prolonged consumption of iron supplements or iron fortified foods. Strategies to decrease the bioavailability of iron in such vulnerable population groups, such as recommending high vegetable diets, deserve future investigation.
publishDate 2018
dc.date.none.fl_str_mv 2018
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/241447
url http://hdl.handle.net/10261/241447
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-53207-C2-2R
https://doi.org/10.19080/CRDOJ.2018.08.555727
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Juniper Publishers
publisher.none.fl_str_mv Juniper Publishers
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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