Smoking history and breast cancer risk by pathological subtype: MCC-Spain study

Introduction: The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action. Methods: In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1...

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Detalles Bibliográficos
Autores: Peñalver Argüeso, Belén, Alguacil Ojeda, Juan, Pérez Gómez, Beatriz
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad de Huelva (UHU)
Repositorio:Arias Montano. Repositorio Institucional de la Universidad de Huelva
Idioma:inglés
OAI Identifier:oai:ariasmontano.uhu.es:10272/23286
Acceso en línea:https://hdl.handle.net/10272/23286
Access Level:acceso abierto
Palabra clave:Breast cancer
Smoking
Obesity
Hormone receptor
HER2
32 Ciencias Médicas
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spelling Smoking history and breast cancer risk by pathological subtype: MCC-Spain studyPeñalver Argüeso, BelénAlguacil Ojeda, JuanPérez Gómez, BeatrizBreast cancerSmokingObesityHormone receptorHER232 Ciencias MédicasIntroduction: The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action. Methods: In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1903 controls, including smoking exposure. The association with breast cancer, overall, by pathological subtype and menopausal status, was assessed using logistic and multinomial regression models. Results: Smokers had higher risk of premenopausal breast cancer, particularly if they had smoked ≥30 years (AOR=1.75; 95% CI: 1.04–2.94), although most estimates did not achieve statistical significance. In contrast, among postmenopausal women, smoking was associated with lower risk of breast cancer, mainly in overweight and obese women. The strongest risk reductions were observed among postmenopausal women who had stopped smoking ≥10 years before cancer diagnosis, particularly for HER2+ tumors (AOR=0.28; 95% CI: 0.11–0.68); p for heterogeneity = 0.040). Also, those who had smoked <10 pack-years (AOR=0.68; 95% CI: 0.47–0.98) or 10–25 pack-years (AOR=0.62; 95% CI: 0.42–0.92) during their lifetime were at a reduced risk of all breast cancer subtypes (p for heterogeneity: 0.405 and 0.475, respectively); however, women who had smoked more than 25 pack-years showed no reduced risk. Conclusions: Menopausal status plays a key role in the relationship between tobacco and breast cancer for all cancer subtypes. While smoking seems to increase the risk in premenopausal woman, it might be associated to lower risk of breast cancer among postmenopausal women with excess weight.EU European Publishing20232023-11-0120232023-11-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10272/23286reponame:Arias Montano. Repositorio Institucional de la Universidad de Huelvainstname:Universidad de Huelva (UHU)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:ariasmontano.uhu.es:10272/232862026-06-02T14:58:11Z
dc.title.none.fl_str_mv Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
spellingShingle Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
Peñalver Argüeso, Belén
Breast cancer
Smoking
Obesity
Hormone receptor
HER2
32 Ciencias Médicas
title_short Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title_full Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title_fullStr Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title_full_unstemmed Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
title_sort Smoking history and breast cancer risk by pathological subtype: MCC-Spain study
dc.creator.none.fl_str_mv Peñalver Argüeso, Belén
Alguacil Ojeda, Juan
Pérez Gómez, Beatriz
author Peñalver Argüeso, Belén
author_facet Peñalver Argüeso, Belén
Alguacil Ojeda, Juan
Pérez Gómez, Beatriz
author_role author
author2 Alguacil Ojeda, Juan
Pérez Gómez, Beatriz
author2_role author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Breast cancer
Smoking
Obesity
Hormone receptor
HER2
32 Ciencias Médicas
topic Breast cancer
Smoking
Obesity
Hormone receptor
HER2
32 Ciencias Médicas
description Introduction: The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action. Methods: In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1903 controls, including smoking exposure. The association with breast cancer, overall, by pathological subtype and menopausal status, was assessed using logistic and multinomial regression models. Results: Smokers had higher risk of premenopausal breast cancer, particularly if they had smoked ≥30 years (AOR=1.75; 95% CI: 1.04–2.94), although most estimates did not achieve statistical significance. In contrast, among postmenopausal women, smoking was associated with lower risk of breast cancer, mainly in overweight and obese women. The strongest risk reductions were observed among postmenopausal women who had stopped smoking ≥10 years before cancer diagnosis, particularly for HER2+ tumors (AOR=0.28; 95% CI: 0.11–0.68); p for heterogeneity = 0.040). Also, those who had smoked <10 pack-years (AOR=0.68; 95% CI: 0.47–0.98) or 10–25 pack-years (AOR=0.62; 95% CI: 0.42–0.92) during their lifetime were at a reduced risk of all breast cancer subtypes (p for heterogeneity: 0.405 and 0.475, respectively); however, women who had smoked more than 25 pack-years showed no reduced risk. Conclusions: Menopausal status plays a key role in the relationship between tobacco and breast cancer for all cancer subtypes. While smoking seems to increase the risk in premenopausal woman, it might be associated to lower risk of breast cancer among postmenopausal women with excess weight.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-11-01
2023
2023-11-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10272/23286
url https://hdl.handle.net/10272/23286
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv EU European Publishing
publisher.none.fl_str_mv EU European Publishing
dc.source.none.fl_str_mv reponame:Arias Montano. Repositorio Institucional de la Universidad de Huelva
instname:Universidad de Huelva (UHU)
instname_str Universidad de Huelva (UHU)
reponame_str Arias Montano. Repositorio Institucional de la Universidad de Huelva
collection Arias Montano. Repositorio Institucional de la Universidad de Huelva
repository.name.fl_str_mv
repository.mail.fl_str_mv
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