Prevalence of Undiagnosed Inflammatory Bowel Disease in Spondyloarthritis Patients.

Background/Objectives : The prevalence of inflammatory bowel disease (IBD) in spondyloarthritis (SpA) patients is unknown. Our objective was to assess the prevalence of undiagnosed IBD in SpA patients, including those with axial spondylarthritis (axSpA) or psoriatic arthritis (PsA). Additionally, we...

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Autores: Sanz-Sanz J, Gutiérrez-Casbas A, Plaza Z, Gratacós J, Rodríguez-Lago I, Marín-Jiménez I, Trujillo-Martín E, Pérez-Pampín E, Barreiro-de Acosta M, Hernández-Hernández MV, Carrillo-Palau M, García-Vivar ML, Muñoz-Villafranca MC, Ladehesa-Pineda ML, Iglesias-Flores E, Merino-Argumánez C, González-Lama Y, Arévalo-Salaet M, Calvet X, Díaz-Gonzalez F
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p6875
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/6875
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105019520779&doi=10.3390%2FJCM14134569&partnerID=40&md5=95c548f86eaa6cdd5c1b7748dca29875
Access Level:acceso abierto
Palabra clave:axial spondylarthritis, fecal calprotectin, inflammatory bowel disease, prevalence undiagnostic, psoriatic arthritis
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spelling Prevalence of Undiagnosed Inflammatory Bowel Disease in Spondyloarthritis Patients.Sanz-Sanz JGutiérrez-Casbas APlaza ZGratacós JRodríguez-Lago IMarín-Jiménez ITrujillo-Martín EPérez-Pampín EBarreiro-de Acosta MHernández-Hernández MVCarrillo-Palau MGarcía-Vivar MLMuñoz-Villafranca MCLadehesa-Pineda MLIglesias-Flores EMerino-Argumánez CGonzález-Lama YArévalo-Salaet MCalvet XDíaz-Gonzalez Faxial spondylarthritis, fecal calprotectin, inflammatory bowel disease, prevalence undiagnostic, psoriatic arthritisBackground/Objectives : The prevalence of inflammatory bowel disease (IBD) in spondyloarthritis (SpA) patients is unknown. Our objective was to assess the prevalence of undiagnosed IBD in SpA patients, including those with axial spondylarthritis (axSpA) or psoriatic arthritis (PsA). Additionally, we examined fecal calprotectin (FC) levels in relation to the accuracy of IBD diagnosis. Methods : EISER was a cross-sectional, multicenter, observational, rheumatologist-gastroenterologist collaborative study. Patients with SpA naïve to biologics were recruited. Demographic and clinical characteristics, disease activity, and treatment information were collected. Patients with FC = 80 µg/g or IBD-related symptoms underwent a colonoscopy or video capsule endoscopy. Receiver operating characteristic analysis assessed the predictive value of FC for IBD diagnosis. Results : Of the 570 patients recruited, 494 were evaluable for the main outcome, 248 (50.2%) had axSpA, and 246 (49.8%) had PsA. Overall, 28/494 patients were diagnosed with IBD (5.7%, 95%CI 3.6-7.7). Sorted by clinical entity, 22 (8.9%, 95%CI 5.3-12.4) axSpA and 6 (2.4%, 95%CI 0.5-4.4) PsA patients had a diagnosis of IBD: 24 (86%, 95%CI 79.4-92.6) had ileal/ileocolonic Crohn's disease (CD), 3 (11%, 95%CI 5.1-16.9) unclassified IBD, and 1 (3.5%, 95%CI 0.0-6.9) ulcerative colitis. The ROC curve for FC and IBD diagnosis (AUC: 0.870, p < 0.001, 95%CI 83.7-89.8) showed that an FC = 147 µg/g had a positive predictive value of 17.4% (95%CI 14.5-20.8) Conclusions : In SpA, the prevalence of undiagnosed IBD was 5.7%, higher in axSpA (8.9%) than in PsA (2.4%) patients, with CD being the most common. SpA patients with FC levels < 147 µg/g had a very low probability of IBD.MDPI2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/6875https://www.scopus.com/inward/record.uri?eid=2-s2.0-105019520779&doi=10.3390%2FJCM14134569&partnerID=40&md5=95c548f86eaa6cdd5c1b7748dca29875Journal of Clinical MedicineISSN: 20770383reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p68752026-06-21T15:30:37Z
dc.title.none.fl_str_mv Prevalence of Undiagnosed Inflammatory Bowel Disease in Spondyloarthritis Patients.
title Prevalence of Undiagnosed Inflammatory Bowel Disease in Spondyloarthritis Patients.
spellingShingle Prevalence of Undiagnosed Inflammatory Bowel Disease in Spondyloarthritis Patients.
Sanz-Sanz J
axial spondylarthritis, fecal calprotectin, inflammatory bowel disease, prevalence undiagnostic, psoriatic arthritis
title_short Prevalence of Undiagnosed Inflammatory Bowel Disease in Spondyloarthritis Patients.
title_full Prevalence of Undiagnosed Inflammatory Bowel Disease in Spondyloarthritis Patients.
title_fullStr Prevalence of Undiagnosed Inflammatory Bowel Disease in Spondyloarthritis Patients.
title_full_unstemmed Prevalence of Undiagnosed Inflammatory Bowel Disease in Spondyloarthritis Patients.
title_sort Prevalence of Undiagnosed Inflammatory Bowel Disease in Spondyloarthritis Patients.
dc.creator.none.fl_str_mv Sanz-Sanz J
Gutiérrez-Casbas A
Plaza Z
Gratacós J
Rodríguez-Lago I
Marín-Jiménez I
Trujillo-Martín E
Pérez-Pampín E
Barreiro-de Acosta M
Hernández-Hernández MV
Carrillo-Palau M
García-Vivar ML
Muñoz-Villafranca MC
Ladehesa-Pineda ML
Iglesias-Flores E
Merino-Argumánez C
González-Lama Y
Arévalo-Salaet M
Calvet X
Díaz-Gonzalez F
author Sanz-Sanz J
author_facet Sanz-Sanz J
Gutiérrez-Casbas A
Plaza Z
Gratacós J
Rodríguez-Lago I
Marín-Jiménez I
Trujillo-Martín E
Pérez-Pampín E
Barreiro-de Acosta M
Hernández-Hernández MV
Carrillo-Palau M
García-Vivar ML
Muñoz-Villafranca MC
Ladehesa-Pineda ML
Iglesias-Flores E
Merino-Argumánez C
González-Lama Y
Arévalo-Salaet M
Calvet X
Díaz-Gonzalez F
author_role author
author2 Gutiérrez-Casbas A
Plaza Z
Gratacós J
Rodríguez-Lago I
Marín-Jiménez I
Trujillo-Martín E
Pérez-Pampín E
Barreiro-de Acosta M
Hernández-Hernández MV
Carrillo-Palau M
García-Vivar ML
Muñoz-Villafranca MC
Ladehesa-Pineda ML
Iglesias-Flores E
Merino-Argumánez C
González-Lama Y
Arévalo-Salaet M
Calvet X
Díaz-Gonzalez F
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv axial spondylarthritis, fecal calprotectin, inflammatory bowel disease, prevalence undiagnostic, psoriatic arthritis
topic axial spondylarthritis, fecal calprotectin, inflammatory bowel disease, prevalence undiagnostic, psoriatic arthritis
description Background/Objectives : The prevalence of inflammatory bowel disease (IBD) in spondyloarthritis (SpA) patients is unknown. Our objective was to assess the prevalence of undiagnosed IBD in SpA patients, including those with axial spondylarthritis (axSpA) or psoriatic arthritis (PsA). Additionally, we examined fecal calprotectin (FC) levels in relation to the accuracy of IBD diagnosis. Methods : EISER was a cross-sectional, multicenter, observational, rheumatologist-gastroenterologist collaborative study. Patients with SpA naïve to biologics were recruited. Demographic and clinical characteristics, disease activity, and treatment information were collected. Patients with FC = 80 µg/g or IBD-related symptoms underwent a colonoscopy or video capsule endoscopy. Receiver operating characteristic analysis assessed the predictive value of FC for IBD diagnosis. Results : Of the 570 patients recruited, 494 were evaluable for the main outcome, 248 (50.2%) had axSpA, and 246 (49.8%) had PsA. Overall, 28/494 patients were diagnosed with IBD (5.7%, 95%CI 3.6-7.7). Sorted by clinical entity, 22 (8.9%, 95%CI 5.3-12.4) axSpA and 6 (2.4%, 95%CI 0.5-4.4) PsA patients had a diagnosis of IBD: 24 (86%, 95%CI 79.4-92.6) had ileal/ileocolonic Crohn's disease (CD), 3 (11%, 95%CI 5.1-16.9) unclassified IBD, and 1 (3.5%, 95%CI 0.0-6.9) ulcerative colitis. The ROC curve for FC and IBD diagnosis (AUC: 0.870, p < 0.001, 95%CI 83.7-89.8) showed that an FC = 147 µg/g had a positive predictive value of 17.4% (95%CI 14.5-20.8) Conclusions : In SpA, the prevalence of undiagnosed IBD was 5.7%, higher in axSpA (8.9%) than in PsA (2.4%) patients, with CD being the most common. SpA patients with FC levels < 147 µg/g had a very low probability of IBD.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/6875
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105019520779&doi=10.3390%2FJCM14134569&partnerID=40&md5=95c548f86eaa6cdd5c1b7748dca29875
url https://i3pt.portalinvestigacion.com/publicaciones/6875
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105019520779&doi=10.3390%2FJCM14134569&partnerID=40&md5=95c548f86eaa6cdd5c1b7748dca29875
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Journal of Clinical Medicine
ISSN: 20770383
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
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