Objective Biomarkers of Outdoor Activity (Vitamin D and CUVAF) in Young Adults with Myopia During and After the SARS-CoV-2 Pandemic

Background/Objectives: Intrinsic biomarkers, such as serum vitamin D levels and the conjunctival ultraviolet autofluorescence (CUVAF) area, have been proposed to quantify sunlight exposure. Evidence suggests that reduced outdoor activity during the SARS-CoV-2 pandemic accelerated the progression of...

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Autores: Gutiérrez Rodríguez, Natali, Puente Carabot, Miriam de la, Rodríguez Hilarion, Javier Andres, Ramos Castaneda, Jorge A., Bilbao Malavé, Valentina, Avendaño Vasquez, Carlos Javier, Gonzalez-zamora, Jorge, Garzón Parra, Sandra Johanna, Recalde Maestre, Sergio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/223345
Acceso en línea:https://hdl.handle.net/2445/223345
Access Level:acceso abierto
Palabra clave:Vitamina D
Miopia
Marcadors bioquímics
Vitamin D
Myopia
Biochemical markers
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spelling Objective Biomarkers of Outdoor Activity (Vitamin D and CUVAF) in Young Adults with Myopia During and After the SARS-CoV-2 PandemicGutiérrez Rodríguez, NataliPuente Carabot, Miriam de laRodríguez Hilarion, Javier AndresRamos Castaneda, Jorge A.Bilbao Malavé, ValentinaAvendaño Vasquez, Carlos JavierGonzalez-zamora, JorgeGarzón Parra, Sandra JohannaRecalde Maestre, SergioVitamina DMiopiaMarcadors bioquímicsVitamin DMyopiaBiochemical markersBackground/Objectives: Intrinsic biomarkers, such as serum vitamin D levels and the conjunctival ultraviolet autofluorescence (CUVAF) area, have been proposed to quantify sunlight exposure. Evidence suggests that reduced outdoor activity during the SARS-CoV-2 pandemic accelerated the progression of myopia; however, there is little information on the impact of such restrictions on vitamin D levels and CUVAF area in populations with myopia. This study aims to assess the association between serum vitamin D levels and conjunctival ultraviolet autofluorescence area (CUVAF) in young adults with myopia during and after the pandemic, as well as its relationship with sun exposure habits and the use of skin protection measures. Methods: A prospective observational study was carried out. A total of 59 students participated, 32 with a diagnosis of myopia and 27 controls, during SARS-CoV-2 pandemic. Two serological tests for total 25-hydroxy vitamin D (D2 + D3) (Calciferol) were taken, activity habits and sun exposure were identified using the Intermountain Live Well Institute tool, and CUVAF images were taken post-pandemic. Results: In the 59 participants, we observed similar vitamin D concentrations between the myopic and control groups during and after the pandemic. However, analysis of CUVAF areas after the pandemic revealed that myopes had significantly smaller areas compared to controls (p < 0.05). Conclusions: The study demonstrated that using vitamin D as a biomarker for outdoor activity requires additional investigation; the CUVAF biomarker showed a significant association with myopia.MDPI2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/223345Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/biomedicines13082042Biomedicines, 2025, vol. 13, num. 8, 2042https://doi.org/10.3390/biomedicines13082042cc-by (c) Gutiérrez Rodríguez, Natali et al., 2025http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2233452026-05-29T05:05:01Z
dc.title.none.fl_str_mv Objective Biomarkers of Outdoor Activity (Vitamin D and CUVAF) in Young Adults with Myopia During and After the SARS-CoV-2 Pandemic
title Objective Biomarkers of Outdoor Activity (Vitamin D and CUVAF) in Young Adults with Myopia During and After the SARS-CoV-2 Pandemic
spellingShingle Objective Biomarkers of Outdoor Activity (Vitamin D and CUVAF) in Young Adults with Myopia During and After the SARS-CoV-2 Pandemic
Gutiérrez Rodríguez, Natali
Vitamina D
Miopia
Marcadors bioquímics
Vitamin D
Myopia
Biochemical markers
title_short Objective Biomarkers of Outdoor Activity (Vitamin D and CUVAF) in Young Adults with Myopia During and After the SARS-CoV-2 Pandemic
title_full Objective Biomarkers of Outdoor Activity (Vitamin D and CUVAF) in Young Adults with Myopia During and After the SARS-CoV-2 Pandemic
title_fullStr Objective Biomarkers of Outdoor Activity (Vitamin D and CUVAF) in Young Adults with Myopia During and After the SARS-CoV-2 Pandemic
title_full_unstemmed Objective Biomarkers of Outdoor Activity (Vitamin D and CUVAF) in Young Adults with Myopia During and After the SARS-CoV-2 Pandemic
title_sort Objective Biomarkers of Outdoor Activity (Vitamin D and CUVAF) in Young Adults with Myopia During and After the SARS-CoV-2 Pandemic
dc.creator.none.fl_str_mv Gutiérrez Rodríguez, Natali
Puente Carabot, Miriam de la
Rodríguez Hilarion, Javier Andres
Ramos Castaneda, Jorge A.
Bilbao Malavé, Valentina
Avendaño Vasquez, Carlos Javier
Gonzalez-zamora, Jorge
Garzón Parra, Sandra Johanna
Recalde Maestre, Sergio
author Gutiérrez Rodríguez, Natali
author_facet Gutiérrez Rodríguez, Natali
Puente Carabot, Miriam de la
Rodríguez Hilarion, Javier Andres
Ramos Castaneda, Jorge A.
Bilbao Malavé, Valentina
Avendaño Vasquez, Carlos Javier
Gonzalez-zamora, Jorge
Garzón Parra, Sandra Johanna
Recalde Maestre, Sergio
author_role author
author2 Puente Carabot, Miriam de la
Rodríguez Hilarion, Javier Andres
Ramos Castaneda, Jorge A.
Bilbao Malavé, Valentina
Avendaño Vasquez, Carlos Javier
Gonzalez-zamora, Jorge
Garzón Parra, Sandra Johanna
Recalde Maestre, Sergio
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Vitamina D
Miopia
Marcadors bioquímics
Vitamin D
Myopia
Biochemical markers
topic Vitamina D
Miopia
Marcadors bioquímics
Vitamin D
Myopia
Biochemical markers
description Background/Objectives: Intrinsic biomarkers, such as serum vitamin D levels and the conjunctival ultraviolet autofluorescence (CUVAF) area, have been proposed to quantify sunlight exposure. Evidence suggests that reduced outdoor activity during the SARS-CoV-2 pandemic accelerated the progression of myopia; however, there is little information on the impact of such restrictions on vitamin D levels and CUVAF area in populations with myopia. This study aims to assess the association between serum vitamin D levels and conjunctival ultraviolet autofluorescence area (CUVAF) in young adults with myopia during and after the pandemic, as well as its relationship with sun exposure habits and the use of skin protection measures. Methods: A prospective observational study was carried out. A total of 59 students participated, 32 with a diagnosis of myopia and 27 controls, during SARS-CoV-2 pandemic. Two serological tests for total 25-hydroxy vitamin D (D2 + D3) (Calciferol) were taken, activity habits and sun exposure were identified using the Intermountain Live Well Institute tool, and CUVAF images were taken post-pandemic. Results: In the 59 participants, we observed similar vitamin D concentrations between the myopic and control groups during and after the pandemic. However, analysis of CUVAF areas after the pandemic revealed that myopes had significantly smaller areas compared to controls (p < 0.05). Conclusions: The study demonstrated that using vitamin D as a biomarker for outdoor activity requires additional investigation; the CUVAF biomarker showed a significant association with myopia.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/223345
url https://hdl.handle.net/2445/223345
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/biomedicines13082042
Biomedicines, 2025, vol. 13, num. 8, 2042
https://doi.org/10.3390/biomedicines13082042
dc.rights.none.fl_str_mv cc-by (c) Gutiérrez Rodríguez, Natali et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Gutiérrez Rodríguez, Natali et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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