Supporting Information. An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence

There is an urgent need to improve conventional cancer-treatments by preventing detrimental side effects, cancer recurrence and metastases. Recent studies have shown that presence of senescent cells in tissues treated with chemo- or radiotherapy can be used to predict the effectiveness of cancer tre...

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Autores: Baker, Andrew G., Hartono, Muhamad, Ou, Hui-Ling, Popov, Andrea Bistrović, Brown, Emma L., Joseph, James, Golinska, Monika, González-Gualda, Estela, Macías, David, Ge, Jianfeng, Denholm, Mary, Morsli, Samir, Sanghera, Chandan, Else, Thomas R., Greer, Heather F., Vernet, Aude, Bohndiek, Sarah E., Muñoz-Espín, Daniel, Fruk, Ljiljana
Tipo de recurso: conjunto de datos
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/371286
Acceso en línea:http://hdl.handle.net/10261/371286
Access Level:acceso abierto
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spelling Supporting Information. An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular SenescenceBaker, Andrew G.Hartono, MuhamadOu, Hui-LingPopov, Andrea BistrovićBrown, Emma L.Joseph, JamesGolinska, MonikaGonzález-Gualda, EstelaMacías, DavidGe, JianfengDenholm, MaryMorsli, SamirSanghera, ChandanElse, Thomas R.Greer, Heather F.Vernet, AudeBohndiek, Sarah E.Muñoz-Espín, DanielFruk, LjiljanaThere is an urgent need to improve conventional cancer-treatments by preventing detrimental side effects, cancer recurrence and metastases. Recent studies have shown that presence of senescent cells in tissues treated with chemo- or radiotherapy can be used to predict the effectiveness of cancer treatment. However, although the accumulation of senescent cells is one of the hallmarks of cancer, surprisingly little progress has been made in development of strategies for their detection in vivo. To address a lack of detection tools, we developed a biocompatible, injectable organic nanoprobe (NanoJagg), which is selectively taken up by senescent cells and accumulates in the lysosomes. The NanoJagg probe is obtained by self-assembly of indocyanine green (ICG) dimers using a scalable manufacturing process and characterized by a unique spectral signature suitable for both photoacoustic tomography (PAT) and fluorescence imaging. In vitro, ex vivo and in vivo studies all indicate that NanoJaggs are a clinically translatable probe for detection of senescence and their PAT signal makes them suitable for longitudinal monitoring of the senescence burden in solid tumors after chemotherapy or radiotherapy.Peer reviewedJohn Wiley & SonsConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/datasethttp://purl.org/coar/resource_type/c_ddb1application/pdfhttp://hdl.handle.net/10261/371286reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésBaker, Andrew G.; Hartono, Muhamad; Ou, Hui-Ling; Popov, Andrea Bistrović; Brown, Emma L.; Joseph, James; Golinska, Monika; González-Gualda, Estela; Macías, David; Ge, Jianfeng; Denholm, Mary; Morsli, Samir; Sanghera, Chandan; Else, Thomas R.; Greer, Heather F.; Vernet, Aude; Bohndiek, Sarah E.; Muñoz-Espín, Daniel; Fruk, Ljiljana. An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence. https://doi.org/10.1002/anie.202404885 . http://hdl.handle.net/10261/371285https://doi.org/10.1002/anie.202404885Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3712862026-05-22T06:33:51Z
dc.title.none.fl_str_mv Supporting Information. An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence
title Supporting Information. An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence
spellingShingle Supporting Information. An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence
Baker, Andrew G.
title_short Supporting Information. An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence
title_full Supporting Information. An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence
title_fullStr Supporting Information. An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence
title_full_unstemmed Supporting Information. An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence
title_sort Supporting Information. An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence
dc.creator.none.fl_str_mv Baker, Andrew G.
Hartono, Muhamad
Ou, Hui-Ling
Popov, Andrea Bistrović
Brown, Emma L.
Joseph, James
Golinska, Monika
González-Gualda, Estela
Macías, David
Ge, Jianfeng
Denholm, Mary
Morsli, Samir
Sanghera, Chandan
Else, Thomas R.
Greer, Heather F.
Vernet, Aude
Bohndiek, Sarah E.
Muñoz-Espín, Daniel
Fruk, Ljiljana
author Baker, Andrew G.
author_facet Baker, Andrew G.
Hartono, Muhamad
Ou, Hui-Ling
Popov, Andrea Bistrović
Brown, Emma L.
Joseph, James
Golinska, Monika
González-Gualda, Estela
Macías, David
Ge, Jianfeng
Denholm, Mary
Morsli, Samir
Sanghera, Chandan
Else, Thomas R.
Greer, Heather F.
Vernet, Aude
Bohndiek, Sarah E.
Muñoz-Espín, Daniel
Fruk, Ljiljana
author_role author
author2 Hartono, Muhamad
Ou, Hui-Ling
Popov, Andrea Bistrović
Brown, Emma L.
Joseph, James
Golinska, Monika
González-Gualda, Estela
Macías, David
Ge, Jianfeng
Denholm, Mary
Morsli, Samir
Sanghera, Chandan
Else, Thomas R.
Greer, Heather F.
Vernet, Aude
Bohndiek, Sarah E.
Muñoz-Espín, Daniel
Fruk, Ljiljana
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description There is an urgent need to improve conventional cancer-treatments by preventing detrimental side effects, cancer recurrence and metastases. Recent studies have shown that presence of senescent cells in tissues treated with chemo- or radiotherapy can be used to predict the effectiveness of cancer treatment. However, although the accumulation of senescent cells is one of the hallmarks of cancer, surprisingly little progress has been made in development of strategies for their detection in vivo. To address a lack of detection tools, we developed a biocompatible, injectable organic nanoprobe (NanoJagg), which is selectively taken up by senescent cells and accumulates in the lysosomes. The NanoJagg probe is obtained by self-assembly of indocyanine green (ICG) dimers using a scalable manufacturing process and characterized by a unique spectral signature suitable for both photoacoustic tomography (PAT) and fluorescence imaging. In vitro, ex vivo and in vivo studies all indicate that NanoJaggs are a clinically translatable probe for detection of senescence and their PAT signal makes them suitable for longitudinal monitoring of the senescence burden in solid tumors after chemotherapy or radiotherapy.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
http://purl.org/coar/resource_type/c_ddb1
format dataset
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/371286
url http://hdl.handle.net/10261/371286
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Baker, Andrew G.; Hartono, Muhamad; Ou, Hui-Ling; Popov, Andrea Bistrović; Brown, Emma L.; Joseph, James; Golinska, Monika; González-Gualda, Estela; Macías, David; Ge, Jianfeng; Denholm, Mary; Morsli, Samir; Sanghera, Chandan; Else, Thomas R.; Greer, Heather F.; Vernet, Aude; Bohndiek, Sarah E.; Muñoz-Espín, Daniel; Fruk, Ljiljana. An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence. https://doi.org/10.1002/anie.202404885 . http://hdl.handle.net/10261/371285
https://doi.org/10.1002/anie.202404885
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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