Exploring the dynamic relationships between nocturnal heart rate, sleep disruptions, anxiety levels, and depression severity over time in recurrent major depressive disorder

Background: Elevated night resting heart rate (HR) has been associated with increased depression severity, yet the underlying mechanisms remain elusive. This study aimed to investigate the mediating role of sleep disturbance and the influence of anxiety on the relationship between night resting HR a...

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Detalles Bibliográficos
Autores: Condominas, Elena, Sánchez Niubò, Albert, Domènech Abella, Joan, Haro Abad, Josep Maria, Bailon, Raquel, Giné Vázquez, Iago, Riquelme, Gemma, Matcham, Faith, Lamers, Femke, Kontaxis, Spyridon, Laporta, Estela, García Pagès, Esther, Peñarrubia Maria, Maria Teresa, White, Katie M., Oetzmann, Carolin, Annas, Peter, Hotopf, Matthew, Penninx, Brenda W. J. H., Narayan, Vaibhav A., Folarin, Amos A., Leightley, Daniel, Cummins, Nicholas, Ranjan, Yatharth, de Girolamo, Giovanni, Preti, Antonio, Simblett, Sara, Wykes, Til, Myin Germeys, Inez, Dobson, Richard J. B., Siddi, Sara, RADAR-CNS consortium
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/224157
Acceso en línea:https://hdl.handle.net/2445/224157
http://hdl.handle.net/2445/224157
Access Level:acceso abierto
Palabra clave:Depressió psíquica
Ansietat
Batecs cardíacs
Trastorns del son
Aparells mòbils
Mental depression
Anxiety
Heart beat
Sleep disorders
Mobile devices
Descripción
Sumario:Background: Elevated night resting heart rate (HR) has been associated with increased depression severity, yet the underlying mechanisms remain elusive. This study aimed to investigate the mediating role of sleep disturbance and the influence of anxiety on the relationship between night resting HR and depression severity. Methods: This is a secondary data analysis of data collected in the Remote Assessment of Disease and Relapse (RADAR) Major Depressive Disorder (MDD) longitudinal mobile health study, encompassing 461 participants (1774 observations) across three national centers (Netherlands, Spain, and the UK). Depression severity, anxiety, and sleep disturbance were assessed every three months. Night resting HR parameters in the 2 weeks preceding assessments were measured using a wrist-worn Fitbit device. Linear mixed models and causal mediation analysis were employed to examine the impact of sleep disturbance and anxiety on night resting HR on depression severity. Covariates included age, sex, BMI, smoking, alcohol consumption, antidepressant use, and comorbidities with other medical conditions. Results: Higher night resting HR was linked to subsequent depressive severity, through the mediation of sleep disturbance. Anxiety contributed to an exacerbated level of sleep disturbance, subsequently intensifying depression severity. Anxiety exhibited no direct effect on night resting HR. Conclusions: Our findings underscore the mediating role of sleep disturbance in the effect of night resting HR on depression severity, and anxiety on depression severity. This insight has potential implications for early identification of indicators signalling worsening depression symptoms, enabling clinicians to initiate timely and responsive treatment measures.

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