Moderate alcohol-associated hepatitis: A real-world multicenter study

Moderate alcohol-associated hepatitis; Mortality; Survival

Detalles Bibliográficos
Autores: Muñoz, Karen, Caldentey, Vicente, Idalsoaga, Francisco, Díaz, Luis Antonio, Dunn, Winston, Mehta, Heer, Ventura-Cots, Meritxell
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/13016
Acceso en línea:http://hdl.handle.net/11351/13016
Access Level:acceso abierto
Palabra clave:Hepatitis - Mortalitat
Alcoholisme - Complicacions
Hepatitis - Prognosi
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
DISEASES::Digestive System Diseases::Liver Diseases::Hepatitis::Hepatitis, Alcoholic
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hepatitis::hepatitis alcohólica
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
id ES_d292e73b0dbbbbb609ab14baa7dc42d6
oai_identifier_str oai:recercat.cat:11351/13016
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Moderate alcohol-associated hepatitis: A real-world multicenter study
title Moderate alcohol-associated hepatitis: A real-world multicenter study
spellingShingle Moderate alcohol-associated hepatitis: A real-world multicenter study
Muñoz, Karen
Hepatitis - Mortalitat
Alcoholisme - Complicacions
Hepatitis - Prognosi
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
DISEASES::Digestive System Diseases::Liver Diseases::Hepatitis::Hepatitis, Alcoholic
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hepatitis::hepatitis alcohólica
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
title_short Moderate alcohol-associated hepatitis: A real-world multicenter study
title_full Moderate alcohol-associated hepatitis: A real-world multicenter study
title_fullStr Moderate alcohol-associated hepatitis: A real-world multicenter study
title_full_unstemmed Moderate alcohol-associated hepatitis: A real-world multicenter study
title_sort Moderate alcohol-associated hepatitis: A real-world multicenter study
dc.creator.none.fl_str_mv Muñoz, Karen
Caldentey, Vicente
Idalsoaga, Francisco
Díaz, Luis Antonio
Dunn, Winston
Mehta, Heer
Ventura-Cots, Meritxell
author Muñoz, Karen
author_facet Muñoz, Karen
Caldentey, Vicente
Idalsoaga, Francisco
Díaz, Luis Antonio
Dunn, Winston
Mehta, Heer
Ventura-Cots, Meritxell
author_role author
author2 Caldentey, Vicente
Idalsoaga, Francisco
Díaz, Luis Antonio
Dunn, Winston
Mehta, Heer
Ventura-Cots, Meritxell
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Idalsoaga F] Departamento De Gastroenterología, Escuela De Medicina, Pontificia Universidad Católica De Chile, Santiago, Chile. Division of Gastroenterology and Hepatology, Department of Medicine, Western University & London Health Sciences Centre, London, Canada. [Díaz LA] Departamento De Gastroenterología, Escuela De Medicina, Pontificia Universidad Católica De Chile, Santiago, Chile. Division of Gastroenterology and Hepatology, Department of Medicine, MASLD Research Center, University of California San Diego, San Diego, California, USA. [Dunn W, Mehta H] Division of Gastroenterology, Department of Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA. [Muñoz K, Caldentey V] Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago. [Ventura Cots M] Servei d’Hepatologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma Barcelona, Bellaterra, Spain. Ciberehd, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Hepatitis - Mortalitat
Alcoholisme - Complicacions
Hepatitis - Prognosi
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
DISEASES::Digestive System Diseases::Liver Diseases::Hepatitis::Hepatitis, Alcoholic
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hepatitis::hepatitis alcohólica
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
topic Hepatitis - Mortalitat
Alcoholisme - Complicacions
Hepatitis - Prognosi
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
DISEASES::Digestive System Diseases::Liver Diseases::Hepatitis::Hepatitis, Alcoholic
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hepatitis::hepatitis alcohólica
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
description Moderate alcohol-associated hepatitis; Mortality; Survival
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11351/13016
http://hdl.handle.net/11351/13016
url http://hdl.handle.net/11351/13016
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Hepatology Communications;9(4)
https://doi.org/10.1097/HC9.0000000000000673
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer Health
publisher.none.fl_str_mv Wolters Kluwer Health
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420384837697536
spelling Moderate alcohol-associated hepatitis: A real-world multicenter studyMuñoz, KarenCaldentey, VicenteIdalsoaga, FranciscoDíaz, Luis AntonioDunn, WinstonMehta, HeerVentura-Cots, MeritxellHepatitis - MortalitatAlcoholisme - ComplicacionsHepatitis - PrognosiANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::PrognosisDISEASES::Digestive System Diseases::Liver Diseases::Hepatitis::Hepatitis, AlcoholicOther subheadings::Other subheadings::Other subheadings::Other subheadings::/mortalityTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronósticoENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hepatitis::hepatitis alcohólicaOtros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidadModerate alcohol-associated hepatitis; Mortality; SurvivalHepatitis moderada associada a l'alcohol; Mortalitat; SupervivènciaHepatitis moderada asociada al alcohol; Mortalidad; SupervivenciaBackground: Severe alcohol-associated hepatitis (sAH) is a well-characterized disease with high short-term mortality. However, there is limited research on those with a “less severe condition” (moderate AH). This study aims to characterize in-depth patients with moderate AH (mAH), including the performance of mortality scoring systems, key prognostic factors, and survival over time. Methods: A multicenter retrospective cohort study (2009–2019) included patients with mAH (MELD score ≤20 at admission). Cox regression and receiver operating characteristic curves with AUC were used for analysis. Results: We included 1845 patients with AH (20 centers, 8 countries) between 2009 and 2019. mAH was defined as a MELD score ≤20 at admission. Twenty-four percent met the criteria for an mAH episode. Patients with mAH tend to be older and have a higher proportion of females, with a median MELD of 17 (15–19), Maddrey discriminant function (mDF) of 33 (22–40), the trajectory of serum bilirubin of 0.83 (0.60–1.21), and neutrophil-to-lymphocyte ratio (NLR) of 5 (2.96–8.60). The primary causes of death in mAH included multiple organ failure (34.1%) and infections (16.6%). The cumulative survival rates at 30, 90, and 180 days were 94.3%, 90.4%, and 88.2%, respectively. In multivariable analysis, age was the only significant predictor of 30-day mortality (HR 1.49, 95% CI: 1.27–1.76, p<0.001). Mortality prediction models showed poor performance, with AUC for MELD (0.671), mDF (0.726), trajectory of serum bilirubin (0.733), and NLR (0.697). Conclusions: Patients with moderate AH exhibited a mortality of 11.8% at 6 months, primarily driven by multiple organ failure and infections. These patients also exhibit a different clinical profile compared to those with sAH. Tailored models and therapeutic strategies are needed to improve long-term outcomes in mAH.Marco Arrese receives support from the Chilean government through the Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT 1241450).Wolters Kluwer HealthInstitut Català de la Salut[Idalsoaga F] Departamento De Gastroenterología, Escuela De Medicina, Pontificia Universidad Católica De Chile, Santiago, Chile. Division of Gastroenterology and Hepatology, Department of Medicine, Western University & London Health Sciences Centre, London, Canada. [Díaz LA] Departamento De Gastroenterología, Escuela De Medicina, Pontificia Universidad Católica De Chile, Santiago, Chile. Division of Gastroenterology and Hepatology, Department of Medicine, MASLD Research Center, University of California San Diego, San Diego, California, USA. [Dunn W, Mehta H] Division of Gastroenterology, Department of Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA. [Muñoz K, Caldentey V] Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago. [Ventura Cots M] Servei d’Hepatologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma Barcelona, Bellaterra, Spain. Ciberehd, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/11351/13016http://hdl.handle.net/11351/13016Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésHepatology Communications;9(4)https://doi.org/10.1097/HC9.0000000000000673Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/130162026-05-29T05:05:01Z
score 15,811543

Similares en LA Referencia