Adrenergic Modulation With Photochromic Ligands

© 2020 Wiley-VCH GmbH Adrenoceptors are ubiquitous and mediate important autonomic functions as well as modulating arousal, cognition, and pain on a central level. Understanding these physiological processes and their underlying neural circuits requires manipulating adrenergic neurotransmission with...

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Detalles Bibliográficos
Autores: Prischich, Davia, Giralt Lledó, Ernest, Hernando, Jordi, Guasch i Casany, Eduard, Meana, J. Javier, Villa, Pedro de la, Gorostiza Langa, Pablo Ignacio, Gomila Juaneda, Alexandre, Milla Navarro, Santiago, Sangüesa Puigventós, Gemma, Diez Alarcia, Rebeca, Preda, Beatrice, Matera, Carlo, Batlle, Montserrat
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/183210
Acceso en línea:https://hdl.handle.net/2445/183210
Access Level:acceso abierto
Palabra clave:Neurotransmissors
Receptors adrenèrgics
Neurotransmitters
Adrenaline receptors
Descripción
Sumario:© 2020 Wiley-VCH GmbH Adrenoceptors are ubiquitous and mediate important autonomic functions as well as modulating arousal, cognition, and pain on a central level. Understanding these physiological processes and their underlying neural circuits requires manipulating adrenergic neurotransmission with high spatio-temporal precision. Here we present a first generation of photochromic ligands (adrenoswitches) obtained via azologization of a class of cyclic amidines related to the known ligand clonidine. Their pharmacology, photochromism, bioavailability, and lack of toxicity allow for broad biological applications, as demonstrated by controlling locomotion in zebrafish and pupillary responses in mice.

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