P-cadherin expression reduced in squamous cell carcinoma of the oral cavity: An indicator of poor prognosis

BACKGROUND. The loss of cadherin expression has been shown to correlate to the invasion and metastasis of many types of carcinomas. The purpose of the current study was to evaluate whether the impaired expression of E-cadherin (E-cad) and P-cadherin (P-cad) correlated with the clinical evolution and...

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Autores: Muñoz Guerra, M.F., Marazuela, E.G., Fernández Contreras, María Encarnación, Gamallo, C.
Formato: artículo
Fecha de publicación:2005
País:España
Recursos:Universidad Alfonso X el Sabio
Repositorio:Repositorio Institucional de la Universidad Alfonso X el Sabio
Idioma:inglés
OAI Identifier:oai:archive.uax.com:20.500.12080/45067
Acesso em linha:https://hdl.handle.net/20.500.12080/45067
Access Level:acceso abierto
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spelling P-cadherin expression reduced in squamous cell carcinoma of the oral cavity: An indicator of poor prognosisMuñoz Guerra, M.F.Marazuela, E.G.Fernández Contreras, María EncarnaciónGamallo, C.BACKGROUND. The loss of cadherin expression has been shown to correlate to the invasion and metastasis of many types of carcinomas. The purpose of the current study was to evaluate whether the impaired expression of E-cadherin (E-cad) and P-cadherin (P-cad) correlated with the clinical evolution and prognosis of oral squamous cell carcinoma (OSCC). METHODS. The authors used immunohistochemical methods to analyze the expression pattern of E-cad and P-cad in healthy oral mucosa, in oral carcinoma in situ (CIS), and in surgical samples of 50 patients with the early stages (Stages I-II) of OSCC. RESULTS. E-cad showed weak expression in the basal layer of the healthy oral mucosa and reduced expression in patients with oral CIS. P-cad expression was conserved on the basal and suprabasal layers of the healthy mucosa and, also, in the CIS. In the group of patients with OSCC, univariate analysis demonstrated that reduced expression of E-cad or P-cad correlated significantly with locoregional disease recurrence in the follow-up (P = 0.03 and P = 0.01, respectively). However, only the reduction in the expression of P-cad emerged as an independent prognostic marker in the multivariate analysis (P = 0.04, hazard ratio = 8.06). CONCLUSIONS. These findings suggested that a decrease in E-cad and/or P-cad expression may contribute to the invasive potential of early OSCC. According to the current data, P-cad expression may be a potential independent prognostic factor in patients with OSCC.UAX Archive20052005-01-0120052005-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12080/45067reponame:Repositorio Institucional de la Universidad Alfonso X el Sabioinstname:Universidad Alfonso X el SabioInglésengopen accesshttp://purl.org/coar/access_right/c_abf2CC-BYhttp://creativecommons.org/licenses/by/4.0/deed.esinfo:eu-repo/semantics/openAccessoai:archive.uax.com:20.500.12080/450672026-05-28T12:40:21Z
dc.title.none.fl_str_mv P-cadherin expression reduced in squamous cell carcinoma of the oral cavity: An indicator of poor prognosis
title P-cadherin expression reduced in squamous cell carcinoma of the oral cavity: An indicator of poor prognosis
spellingShingle P-cadherin expression reduced in squamous cell carcinoma of the oral cavity: An indicator of poor prognosis
Muñoz Guerra, M.F.
title_short P-cadherin expression reduced in squamous cell carcinoma of the oral cavity: An indicator of poor prognosis
title_full P-cadherin expression reduced in squamous cell carcinoma of the oral cavity: An indicator of poor prognosis
title_fullStr P-cadherin expression reduced in squamous cell carcinoma of the oral cavity: An indicator of poor prognosis
title_full_unstemmed P-cadherin expression reduced in squamous cell carcinoma of the oral cavity: An indicator of poor prognosis
title_sort P-cadherin expression reduced in squamous cell carcinoma of the oral cavity: An indicator of poor prognosis
dc.creator.none.fl_str_mv Muñoz Guerra, M.F.
Marazuela, E.G.
Fernández Contreras, María Encarnación
Gamallo, C.
author Muñoz Guerra, M.F.
author_facet Muñoz Guerra, M.F.
Marazuela, E.G.
Fernández Contreras, María Encarnación
Gamallo, C.
author_role author
author2 Marazuela, E.G.
Fernández Contreras, María Encarnación
Gamallo, C.
author2_role author
author
author
dc.contributor.none.fl_str_mv UAX Archive
description BACKGROUND. The loss of cadherin expression has been shown to correlate to the invasion and metastasis of many types of carcinomas. The purpose of the current study was to evaluate whether the impaired expression of E-cadherin (E-cad) and P-cadherin (P-cad) correlated with the clinical evolution and prognosis of oral squamous cell carcinoma (OSCC). METHODS. The authors used immunohistochemical methods to analyze the expression pattern of E-cad and P-cad in healthy oral mucosa, in oral carcinoma in situ (CIS), and in surgical samples of 50 patients with the early stages (Stages I-II) of OSCC. RESULTS. E-cad showed weak expression in the basal layer of the healthy oral mucosa and reduced expression in patients with oral CIS. P-cad expression was conserved on the basal and suprabasal layers of the healthy mucosa and, also, in the CIS. In the group of patients with OSCC, univariate analysis demonstrated that reduced expression of E-cad or P-cad correlated significantly with locoregional disease recurrence in the follow-up (P = 0.03 and P = 0.01, respectively). However, only the reduction in the expression of P-cad emerged as an independent prognostic marker in the multivariate analysis (P = 0.04, hazard ratio = 8.06). CONCLUSIONS. These findings suggested that a decrease in E-cad and/or P-cad expression may contribute to the invasive potential of early OSCC. According to the current data, P-cad expression may be a potential independent prognostic factor in patients with OSCC.
publishDate 2005
dc.date.none.fl_str_mv 2005
2005-01-01
2005
2005-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12080/45067
url https://hdl.handle.net/20.500.12080/45067
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
CC-BY
http://creativecommons.org/licenses/by/4.0/deed.es
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
CC-BY
http://creativecommons.org/licenses/by/4.0/deed.es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositorio Institucional de la Universidad Alfonso X el Sabio
instname:Universidad Alfonso X el Sabio
instname_str Universidad Alfonso X el Sabio
reponame_str Repositorio Institucional de la Universidad Alfonso X el Sabio
collection Repositorio Institucional de la Universidad Alfonso X el Sabio
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repository.mail.fl_str_mv
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