Paternal Inheritance of Bisphenol A Cardiotoxic Effects: The Implications of Sperm Epigenome

Departamento de Reproducción Animal​ (INIA)

Detalles Bibliográficos
Autores: Lombó, Marta, Herráez, María Paz
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/275380
Acceso en línea:http://hdl.handle.net/10261/275380
https://api.elsevier.com/content/abstract/scopus_id/85100925743
Access Level:acceso abierto
Palabra clave:Bisphenol A
Heart development
Histone acetylation
Paternal exposure
Sperm epigenome
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spelling Paternal Inheritance of Bisphenol A Cardiotoxic Effects: The Implications of Sperm EpigenomeLombó, MartaHerráez, María PazBisphenol AHeart developmentHistone acetylationPaternal exposureSperm epigenomeDepartamento de Reproducción Animal​ (INIA)Parental exposure to bisphenol A (BPA) has been linked to a greater incidence of congenital diseases. We have demonstrated that BPA induces in zebrafish males an increase in the acetylation of sperm histones that is transmitted to the blastomeres of the unexposed progeny. This work is aimed to determine whether histone hyperacetylation promoted by paternal exposure to BPA is the molecular mechanism underlying the cardiogenesis impairment in the descendants. Zebrafish males were exposed to 100 and 2000 µg/L BPA during early spermatogenesis and mated with non-exposed females. We analyzed in the progeny the expression of genes involved in cardiogenesis and the epigenetic profile. Once the histone hyperacetylation was confirmed, treatment with epigallocatechin gallate (EGCG), an inhibitor of histone acetyltransferases, was assayed on F1 embryos. Embryos from males exposed to 2000 µg/L BPA overexpressed the transcription factor hand2 and the receptor esr2b, showing their own promoters-as well as that of kat6a-an enrichment in H3K9ac. In embryos treated with EGCG, both gene expression and histone acetylation (global and specific) returned to basal levels, and the phenotype was recovered. As shown by the results, the histone hyperacetylated landscape promoted by BPA in the sperm alters the chromatin structure of the progeny, leading to the overexpression of the histone acetyltransferase and genes involved in cardiogenesis.This work was funded by the Spanish Ministry of Economy and Competitiveness (Project AGL2014-53167-C3-3-R; PhD Grant BES- 2015-071885) and it was awarded by Fundación Carolina Rodríguez (Universidad de León) in the 24th edition of “Premios Mariano Rodríguez para jóvenes investigadores”Peer reviewed15 Pág.Multidisciplinary Digital Publishing InstituteMinisterio de Economía y Competitividad (España)Lombó, Marta [0000-0002-2042-798X]Herráez, María Paz [0000-0002-0028-3616]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/275380https://api.elsevier.com/content/abstract/scopus_id/85100925743reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//AGL2014-53167-C3-3-RInternational journal of molecular scienceshttps://doi.org/10.3390/ijms22042125Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2753802026-05-22T06:33:51Z
dc.title.none.fl_str_mv Paternal Inheritance of Bisphenol A Cardiotoxic Effects: The Implications of Sperm Epigenome
title Paternal Inheritance of Bisphenol A Cardiotoxic Effects: The Implications of Sperm Epigenome
spellingShingle Paternal Inheritance of Bisphenol A Cardiotoxic Effects: The Implications of Sperm Epigenome
Lombó, Marta
Bisphenol A
Heart development
Histone acetylation
Paternal exposure
Sperm epigenome
title_short Paternal Inheritance of Bisphenol A Cardiotoxic Effects: The Implications of Sperm Epigenome
title_full Paternal Inheritance of Bisphenol A Cardiotoxic Effects: The Implications of Sperm Epigenome
title_fullStr Paternal Inheritance of Bisphenol A Cardiotoxic Effects: The Implications of Sperm Epigenome
title_full_unstemmed Paternal Inheritance of Bisphenol A Cardiotoxic Effects: The Implications of Sperm Epigenome
title_sort Paternal Inheritance of Bisphenol A Cardiotoxic Effects: The Implications of Sperm Epigenome
dc.creator.none.fl_str_mv Lombó, Marta
Herráez, María Paz
author Lombó, Marta
author_facet Lombó, Marta
Herráez, María Paz
author_role author
author2 Herráez, María Paz
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Lombó, Marta [0000-0002-2042-798X]
Herráez, María Paz [0000-0002-0028-3616]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Bisphenol A
Heart development
Histone acetylation
Paternal exposure
Sperm epigenome
topic Bisphenol A
Heart development
Histone acetylation
Paternal exposure
Sperm epigenome
description Departamento de Reproducción Animal​ (INIA)
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/275380
https://api.elsevier.com/content/abstract/scopus_id/85100925743
url http://hdl.handle.net/10261/275380
https://api.elsevier.com/content/abstract/scopus_id/85100925743
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//AGL2014-53167-C3-3-R
International journal of molecular sciences
https://doi.org/10.3390/ijms22042125
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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