The neurobiological basis of cognitive side effects of electroconvulsive therapy

Decades of research have consistently demonstrated the efficacy of electroconvulsive therapy (ECT) for the treatment of major depressive disorder (MDD), but its clinical use remains somewhat restricted because of its cognitive side effects. The aim of this systematic review is to comprehensively sum...

Descripción completa

Detalles Bibliográficos
Autores: Bassa, Adriana, Sagués, Teresa, Porta-Casteràs, Daniel|||0000-0002-3921-3607, Serra, Pilar, Martínez Amorós, Erika|||0000-0002-6718-7346, Palao, Diego|||0000-0002-3323-6568, Cano, Marta|||0000-0003-0675-9483, Cardoner, Narcís|||0000-0001-9633-0888
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:252023
Acceso en línea:https://ddd.uab.cat/record/252023
https://dx.doi.org/urn:doi:10.3390/brainsci11101273
Access Level:acceso abierto
Palabra clave:Electroconvulsive therapy
ECT
Memory
Cognitive impairment
Side effects
MDD
Biomarkers
Hippocampus
NSE
S-100
id ES_d24d31b266eb0648dfd8ac87bf487cf9
oai_identifier_str oai:ddd.uab.cat:252023
network_acronym_str ES
network_name_str España
repository_id_str
spelling The neurobiological basis of cognitive side effects of electroconvulsive therapya systematic reviewBassa, AdrianaSagués, TeresaPorta-Casteràs, Daniel|||0000-0002-3921-3607Serra, PilarMartínez Amorós, Erika|||0000-0002-6718-7346Palao, Diego|||0000-0002-3323-6568Cano, Marta|||0000-0003-0675-9483Cardoner, Narcís|||0000-0001-9633-0888Electroconvulsive therapyECTMemoryCognitive impairmentSide effectsMDDBiomarkersHippocampusNSES-100Decades of research have consistently demonstrated the efficacy of electroconvulsive therapy (ECT) for the treatment of major depressive disorder (MDD), but its clinical use remains somewhat restricted because of its cognitive side effects. The aim of this systematic review is to comprehensively summarize current evidence assessing potential biomarkers of ECT-related cognitive side effects. Based on our systematic search of human studies indexed in PubMed, Scopus, and Web of Knowledge, a total of 29 studies evaluating patients with MDD undergoing ECT were reviewed. Molecular biomarkers studies did not consistently identify concentration changes in plasma S-100 protein, neuron-specific enolase (NSE), or Aβ peptides significantly associated with cognitive performance after ECT. Importantly, these findings suggest that ECT-related cognitive side effects cannot be explained by mechanisms of neural cell damage. Notwithstanding, S-100b protein and Aβ40 peptide concentrations, as well as brain-derived neurotrophic factor (BDNF) polymorphisms, have been suggested as potential predictive biomarkers of cognitive dysfunction after ECT. In addition, recent advances in brain imaging have allowed us to identify ECT-induced volumetric and functional changes in several brain structures closely related to memory performance such as the hippocampus. We provide a preliminary framework to further evaluate neurobiological cognitive vulnerability profiles of patients with MDD treated with ECT. 22021-01-0120212021-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/252023https://dx.doi.org/urn:doi:10.3390/brainsci11101273reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 FI19/00251Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00036open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2520232026-06-06T12:50:31Z
dc.title.none.fl_str_mv The neurobiological basis of cognitive side effects of electroconvulsive therapy
a systematic review
title The neurobiological basis of cognitive side effects of electroconvulsive therapy
spellingShingle The neurobiological basis of cognitive side effects of electroconvulsive therapy
Bassa, Adriana
Electroconvulsive therapy
ECT
Memory
Cognitive impairment
Side effects
MDD
Biomarkers
Hippocampus
NSE
S-100
title_short The neurobiological basis of cognitive side effects of electroconvulsive therapy
title_full The neurobiological basis of cognitive side effects of electroconvulsive therapy
title_fullStr The neurobiological basis of cognitive side effects of electroconvulsive therapy
title_full_unstemmed The neurobiological basis of cognitive side effects of electroconvulsive therapy
title_sort The neurobiological basis of cognitive side effects of electroconvulsive therapy
dc.creator.none.fl_str_mv Bassa, Adriana
Sagués, Teresa
Porta-Casteràs, Daniel|||0000-0002-3921-3607
Serra, Pilar
Martínez Amorós, Erika|||0000-0002-6718-7346
Palao, Diego|||0000-0002-3323-6568
Cano, Marta|||0000-0003-0675-9483
Cardoner, Narcís|||0000-0001-9633-0888
author Bassa, Adriana
author_facet Bassa, Adriana
Sagués, Teresa
Porta-Casteràs, Daniel|||0000-0002-3921-3607
Serra, Pilar
Martínez Amorós, Erika|||0000-0002-6718-7346
Palao, Diego|||0000-0002-3323-6568
Cano, Marta|||0000-0003-0675-9483
Cardoner, Narcís|||0000-0001-9633-0888
author_role author
author2 Sagués, Teresa
Porta-Casteràs, Daniel|||0000-0002-3921-3607
Serra, Pilar
Martínez Amorós, Erika|||0000-0002-6718-7346
Palao, Diego|||0000-0002-3323-6568
Cano, Marta|||0000-0003-0675-9483
Cardoner, Narcís|||0000-0001-9633-0888
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Electroconvulsive therapy
ECT
Memory
Cognitive impairment
Side effects
MDD
Biomarkers
Hippocampus
NSE
S-100
topic Electroconvulsive therapy
ECT
Memory
Cognitive impairment
Side effects
MDD
Biomarkers
Hippocampus
NSE
S-100
description Decades of research have consistently demonstrated the efficacy of electroconvulsive therapy (ECT) for the treatment of major depressive disorder (MDD), but its clinical use remains somewhat restricted because of its cognitive side effects. The aim of this systematic review is to comprehensively summarize current evidence assessing potential biomarkers of ECT-related cognitive side effects. Based on our systematic search of human studies indexed in PubMed, Scopus, and Web of Knowledge, a total of 29 studies evaluating patients with MDD undergoing ECT were reviewed. Molecular biomarkers studies did not consistently identify concentration changes in plasma S-100 protein, neuron-specific enolase (NSE), or Aβ peptides significantly associated with cognitive performance after ECT. Importantly, these findings suggest that ECT-related cognitive side effects cannot be explained by mechanisms of neural cell damage. Notwithstanding, S-100b protein and Aβ40 peptide concentrations, as well as brain-derived neurotrophic factor (BDNF) polymorphisms, have been suggested as potential predictive biomarkers of cognitive dysfunction after ECT. In addition, recent advances in brain imaging have allowed us to identify ECT-induced volumetric and functional changes in several brain structures closely related to memory performance such as the hippocampus. We provide a preliminary framework to further evaluate neurobiological cognitive vulnerability profiles of patients with MDD treated with ECT.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/252023
https://dx.doi.org/urn:doi:10.3390/brainsci11101273
url https://ddd.uab.cat/record/252023
https://dx.doi.org/urn:doi:10.3390/brainsci11101273
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 FI19/00251
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00036
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420338704547840
score 15,811543

Similares en LA Referencia