Efficient algorithms for constructing D- and I-optimal exact designs for linear and non-linear models in mixture experiments.

The problem of finding optimal exact designs is more challenging than that of approximate optimal designs. In the present paper, we develop two efficient algorithms to numerically construct exact designs for mixture experiments. The first is a novel approach to the well-known multiplicative algorith...

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Detalhes bibliográficos
Autores: Martín Martín, Raúl, García-Camacha Gutiérrez, Irene, Torsney, Bernard
Tipo de documento: artigo
Data de publicação:2019
País:España
Recursos:Universidad de Castilla-La Mancha
Repositório:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/25158
Acesso em linha:http://hdl.handle.net/10578/25158
Access Level:Acceso aberto
Palavra-chave:Optimal experimental design
D-optimality
I-optimality
Mixture experiments
Multiplicative algorithm
Genetic algorithm
Exact designs
Descrição
Resumo:The problem of finding optimal exact designs is more challenging than that of approximate optimal designs. In the present paper, we develop two efficient algorithms to numerically construct exact designs for mixture experiments. The first is a novel approach to the well-known multiplicative algorithm based on sets of permutation points, while the second uses genetic algorithms. Using (i) linear and non-linear models, (ii) D- and I-optimality criteria, and (iii) constraints on the ingredients, both approaches are explored through several practical problems arising in the chemical, pharmaceutical and oil industry.