The Interplay between Bluetongue Virus Infections and Adaptive Immunity

17 Pág. Centro de Investigación en Sanidad Animal (CISA)

Detalles Bibliográficos
Autores: Rodríguez-Martín, Daniel, Louloudes-Lázaro, Andrés, Avia, Miguel, Martín, Verónica, Rojas, José Manuel, Sevilla, Noemí
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/287191
Acceso en línea:http://hdl.handle.net/10261/287191
https://api.elsevier.com/content/abstract/scopus_id/85112602603
Access Level:acceso abierto
Palabra clave:B-cells
T-cells
T-helper cells
Cytotoxic T-lymphocytes
Gamma-delta T-cells
Orbivirus
Ruminants
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spelling The Interplay between Bluetongue Virus Infections and Adaptive ImmunityRodríguez-Martín, DanielLouloudes-Lázaro, AndrésAvia, MiguelMartín, VerónicaRojas, José ManuelSevilla, NoemíB-cellsT-cellsT-helper cellsCytotoxic T-lymphocytesGamma-delta T-cellsOrbivirusRuminants17 Pág. Centro de Investigación en Sanidad Animal (CISA)Viral infections have long provided a platform to understand the workings of immunity. For instance, great strides towards defining basic immunology concepts, such as MHC restriction of antigen presentation or T-cell memory development and maintenance, have been achieved thanks to the study of lymphocytic choriomeningitis virus (LCMV) infections. These studies have also shaped our understanding of antiviral immunity, and in particular T-cell responses. In the present review, we discuss how bluetongue virus (BTV), an economically important arbovirus from the Reoviridae family that affects ruminants, affects adaptive immunity in the natural hosts. During the initial stages of infection, BTV triggers leucopenia in the hosts. The host then mounts an adaptive immune response that controls the disease. In this work, we discuss how BTV triggers CD8+ T-cell expansion and neutralizing antibody responses, yet in some individuals viremia remains detectable after these adaptive immune mechanisms are active. We present some unpublished data showing that BTV infection also affects other T cell populations such as CD4+ T-cells or γδ T-cells, as well as B-cell numbers in the periphery. This review also discusses how BTV evades these adaptive immune mechanisms so that it can be transmitted back to the arthropod host. Understanding the interaction of BTV with immunity could ultimately define the correlates of protection with immune mechanisms that would improve our knowledge of ruminant immunology.This work was funded by grants RTI2018-094616-B-100 from the Ministerio de Ciencia (Spain) and S2018/BAA-4370-PLATESA2 from Comunidad de Madrid (Fondo Europeo de Desarrollo Regional, FEDER). MA was funded by an FPI grant (BES-2013-066406). ALL was funded by an FPI grant (INIA).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia e Innovación (España)Comunidad de MadridEuropean CommissionLouloudes-Lázaro, Andrés [0000-0001-6263-8606]Avia, Miguel [0000-0001-7661-4779]Martín, Verónica [0000-0003-1486-1656]Rojas, José Manuel [0000-0002-4055-3967]Sevilla, Noemí [0000-0003-0118-0376]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/287191https://api.elsevier.com/content/abstract/scopus_id/85112602603reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MICINN//RTI2018-094616-B-100S2018/BAA-4370/PLATESA2Viruseshttps://doi.org/10.3390/v13081511Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2871912026-05-22T06:33:51Z
dc.title.none.fl_str_mv The Interplay between Bluetongue Virus Infections and Adaptive Immunity
title The Interplay between Bluetongue Virus Infections and Adaptive Immunity
spellingShingle The Interplay between Bluetongue Virus Infections and Adaptive Immunity
Rodríguez-Martín, Daniel
B-cells
T-cells
T-helper cells
Cytotoxic T-lymphocytes
Gamma-delta T-cells
Orbivirus
Ruminants
title_short The Interplay between Bluetongue Virus Infections and Adaptive Immunity
title_full The Interplay between Bluetongue Virus Infections and Adaptive Immunity
title_fullStr The Interplay between Bluetongue Virus Infections and Adaptive Immunity
title_full_unstemmed The Interplay between Bluetongue Virus Infections and Adaptive Immunity
title_sort The Interplay between Bluetongue Virus Infections and Adaptive Immunity
dc.creator.none.fl_str_mv Rodríguez-Martín, Daniel
Louloudes-Lázaro, Andrés
Avia, Miguel
Martín, Verónica
Rojas, José Manuel
Sevilla, Noemí
author Rodríguez-Martín, Daniel
author_facet Rodríguez-Martín, Daniel
Louloudes-Lázaro, Andrés
Avia, Miguel
Martín, Verónica
Rojas, José Manuel
Sevilla, Noemí
author_role author
author2 Louloudes-Lázaro, Andrés
Avia, Miguel
Martín, Verónica
Rojas, José Manuel
Sevilla, Noemí
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Comunidad de Madrid
European Commission
Louloudes-Lázaro, Andrés [0000-0001-6263-8606]
Avia, Miguel [0000-0001-7661-4779]
Martín, Verónica [0000-0003-1486-1656]
Rojas, José Manuel [0000-0002-4055-3967]
Sevilla, Noemí [0000-0003-0118-0376]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv B-cells
T-cells
T-helper cells
Cytotoxic T-lymphocytes
Gamma-delta T-cells
Orbivirus
Ruminants
topic B-cells
T-cells
T-helper cells
Cytotoxic T-lymphocytes
Gamma-delta T-cells
Orbivirus
Ruminants
description 17 Pág. Centro de Investigación en Sanidad Animal (CISA)
publishDate 2021
dc.date.none.fl_str_mv 2021
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/287191
https://api.elsevier.com/content/abstract/scopus_id/85112602603
url http://hdl.handle.net/10261/287191
https://api.elsevier.com/content/abstract/scopus_id/85112602603
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MICINN//RTI2018-094616-B-100
S2018/BAA-4370/PLATESA2
Viruses
https://doi.org/10.3390/v13081511
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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