Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes

Background Fatty Liver Index (FLI) is strongly associated with changes in glycemic status and incident Type 2 Diabetes (T2D). The probability of reverting to normoglycemia from a state prediabetes could be determined by FLI, however such relationship remains poorly understood. Aim To determine the c...

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Detalles Bibliográficos
Autores: Busquets-Cortés, Carla, Bennasar-Veny, Miquel, López-González, Ángel Arturo, Fresneda, Sergio, Abbate, Manuela, Yáñez, Aina Maria
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/19898
Acceso en línea:https://hdl.handle.net/20.500.13003/19898
Access Level:acceso abierto
Palabra clave:Area Under Curve
Aged
Blood Glucose
Young Adult
Adult
Humans
Life Style
Middle Aged
Fatty Liver
Prediabetic State
Male
Severity of Illness Index
Diet, Healthy
Female
Odds Ratio
Cohort Studies
ROC Curve
Exercise
Logistic Models
Estudios de Cohortes
Ejercicio Físico
Dieta Saludable
Modelos Logísticos
Oportunidad Relativa
Femenino
Masculino
Hígado Graso
Humanos
Persona de Mediana Edad
Glucemia
Adulto Joven
Estilo de Vida
Estado Prediabético
Anciano
Índice de Severidad de la Enfermedad
Adulto
Área Bajo la Curva
Curva ROC
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repository_id_str
spelling Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetesBusquets-Cortés, CarlaBennasar-Veny, MiquelLópez-González, Ángel ArturoFresneda, SergioAbbate, ManuelaYáñez, Aina MariaArea Under CurveAgedBlood GlucoseYoung AdultAdultHumansLife StyleMiddle AgedFatty LiverPrediabetic StateMaleSeverity of Illness IndexDiet, HealthyFemaleOdds RatioCohort StudiesROC CurveExerciseLogistic ModelsEstudios de CohortesEjercicio FísicoDieta SaludableModelos LogísticosOportunidad RelativaFemeninoMasculinoHígado GrasoHumanosPersona de Mediana EdadGlucemiaAdulto JovenEstilo de VidaEstado PrediabéticoAncianoÍndice de Severidad de la EnfermedadAdultoÁrea Bajo la CurvaCurva ROCBackground Fatty Liver Index (FLI) is strongly associated with changes in glycemic status and incident Type 2 Diabetes (T2D). The probability of reverting to normoglycemia from a state prediabetes could be determined by FLI, however such relationship remains poorly understood. Aim To determine the clinical interest of using FLI to estimate prediabetes reversion at 5 years in patients with impaired fasting plasma glucose at baseline, and identify those factors associated with changes in FLI, that could contribute to the reversion of prediabetes. Methods This 5-year cohort study included 16,648 Spanish working adults with prediabetes. Prediabetes was defined as fasting plasma glucose (FPG) between 100 and 125 mg/dl according to the ADA criteria, while prediabetes reversion was defined as a FPG <100 mg/dL. The population was classified as: FLI <30 (no hepatic steatosis), FLI 30-59 (intermediate status), and FLI >= 60 (hepatic steatosis). Results At 5 years follow-up, 33.7% of subjects reverted to normoglycemia (annual rate of 6.7%). The adjusted binomial logistic regression model showed that scoring FLI <30 (OR 1.544; 95% CI 1.355-1.759), performing at least 150 min/week of physical activity (OR 4.600; 95% CI 4.088-5.177) and consuming fruits and vegetables daily (OR 1.682; 95% CI 1.526-1.855) were associated with the probability of reverting form prediabetes to normoglycemia. The ROC curve for prediction of reversion showed that FLI (AUC 0.774;95% CI 0.767-0.781) was a better predictor than FPG (AUC 0.656; 95% CI 0.648-0.664). Conclusions Regular physical activity, healthy dietary habits and absence of hepatic steatosis are independently associated with the probability of reversion to normoglycemia in adult workers with prediabetes at baseline. Low FLI values (especially FLI< 30) may be useful to predict the probability of prediabetes reversion, especially in active subjects with healthy eating habits, and thus identify those who might benefit from early lifestyle intervention.Public Library Science20212021-04-0620212021-04-06research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/19898reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/198982026-06-22T12:44:07Z
dc.title.none.fl_str_mv Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes
title Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes
spellingShingle Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes
Busquets-Cortés, Carla
Area Under Curve
Aged
Blood Glucose
Young Adult
Adult
Humans
Life Style
Middle Aged
Fatty Liver
Prediabetic State
Male
Severity of Illness Index
Diet, Healthy
Female
Odds Ratio
Cohort Studies
ROC Curve
Exercise
Logistic Models
Estudios de Cohortes
Ejercicio Físico
Dieta Saludable
Modelos Logísticos
Oportunidad Relativa
Femenino
Masculino
Hígado Graso
Humanos
Persona de Mediana Edad
Glucemia
Adulto Joven
Estilo de Vida
Estado Prediabético
Anciano
Índice de Severidad de la Enfermedad
Adulto
Área Bajo la Curva
Curva ROC
title_short Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes
title_full Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes
title_fullStr Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes
title_full_unstemmed Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes
title_sort Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes
dc.creator.none.fl_str_mv Busquets-Cortés, Carla
Bennasar-Veny, Miquel
López-González, Ángel Arturo
Fresneda, Sergio
Abbate, Manuela
Yáñez, Aina Maria
author Busquets-Cortés, Carla
author_facet Busquets-Cortés, Carla
Bennasar-Veny, Miquel
López-González, Ángel Arturo
Fresneda, Sergio
Abbate, Manuela
Yáñez, Aina Maria
author_role author
author2 Bennasar-Veny, Miquel
López-González, Ángel Arturo
Fresneda, Sergio
Abbate, Manuela
Yáñez, Aina Maria
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Area Under Curve
Aged
Blood Glucose
Young Adult
Adult
Humans
Life Style
Middle Aged
Fatty Liver
Prediabetic State
Male
Severity of Illness Index
Diet, Healthy
Female
Odds Ratio
Cohort Studies
ROC Curve
Exercise
Logistic Models
Estudios de Cohortes
Ejercicio Físico
Dieta Saludable
Modelos Logísticos
Oportunidad Relativa
Femenino
Masculino
Hígado Graso
Humanos
Persona de Mediana Edad
Glucemia
Adulto Joven
Estilo de Vida
Estado Prediabético
Anciano
Índice de Severidad de la Enfermedad
Adulto
Área Bajo la Curva
Curva ROC
topic Area Under Curve
Aged
Blood Glucose
Young Adult
Adult
Humans
Life Style
Middle Aged
Fatty Liver
Prediabetic State
Male
Severity of Illness Index
Diet, Healthy
Female
Odds Ratio
Cohort Studies
ROC Curve
Exercise
Logistic Models
Estudios de Cohortes
Ejercicio Físico
Dieta Saludable
Modelos Logísticos
Oportunidad Relativa
Femenino
Masculino
Hígado Graso
Humanos
Persona de Mediana Edad
Glucemia
Adulto Joven
Estilo de Vida
Estado Prediabético
Anciano
Índice de Severidad de la Enfermedad
Adulto
Área Bajo la Curva
Curva ROC
description Background Fatty Liver Index (FLI) is strongly associated with changes in glycemic status and incident Type 2 Diabetes (T2D). The probability of reverting to normoglycemia from a state prediabetes could be determined by FLI, however such relationship remains poorly understood. Aim To determine the clinical interest of using FLI to estimate prediabetes reversion at 5 years in patients with impaired fasting plasma glucose at baseline, and identify those factors associated with changes in FLI, that could contribute to the reversion of prediabetes. Methods This 5-year cohort study included 16,648 Spanish working adults with prediabetes. Prediabetes was defined as fasting plasma glucose (FPG) between 100 and 125 mg/dl according to the ADA criteria, while prediabetes reversion was defined as a FPG <100 mg/dL. The population was classified as: FLI <30 (no hepatic steatosis), FLI 30-59 (intermediate status), and FLI >= 60 (hepatic steatosis). Results At 5 years follow-up, 33.7% of subjects reverted to normoglycemia (annual rate of 6.7%). The adjusted binomial logistic regression model showed that scoring FLI <30 (OR 1.544; 95% CI 1.355-1.759), performing at least 150 min/week of physical activity (OR 4.600; 95% CI 4.088-5.177) and consuming fruits and vegetables daily (OR 1.682; 95% CI 1.526-1.855) were associated with the probability of reverting form prediabetes to normoglycemia. The ROC curve for prediction of reversion showed that FLI (AUC 0.774;95% CI 0.767-0.781) was a better predictor than FPG (AUC 0.656; 95% CI 0.648-0.664). Conclusions Regular physical activity, healthy dietary habits and absence of hepatic steatosis are independently associated with the probability of reversion to normoglycemia in adult workers with prediabetes at baseline. Low FLI values (especially FLI< 30) may be useful to predict the probability of prediabetes reversion, especially in active subjects with healthy eating habits, and thus identify those who might benefit from early lifestyle intervention.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-04-06
2021
2021-04-06
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/19898
url https://hdl.handle.net/20.500.13003/19898
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library Science
publisher.none.fl_str_mv Public Library Science
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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